DSSTox

Distributed Structure-Searchable Toxicity (DSSTox) Database Network is a project of EPA's National Center for Computational Toxicology, helping to build a public data foundation for improved structure-activity and predictive toxicology capabilities. The DSSTox website provides a public forum for publishing downloadable, structure-searchable, standardized chemical structure files associated with toxicity data. More>

v2.0

DSSTox Structure-Browser information Page

27 October 2008

ARYEXP: European Bioinformatics Institute (EBI) ArrayExpress Repository for Gene Expression Experiments ** New Files
Structure-index locator file corresponds to chemical exposure-related experiments in ArrayExpress Repository with links to Experimental Accession numbers associated with each substance (data extracted 20Sept2008). Auxiliary data file (ARYEXP_Aux) indexed by chemical-experiment pair, includes 44 additional data fields.

GEOGSE: National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) Series Experiments ** New Files
Structure-index locator file corresponds to chemical exposure-related experiments of GEO Series Repository with links to Series Accession numbers associated with each substance (data extracted 20Sept2008). Auxiliary data file (GEOGSE_Aux) indexed by chemical-experiment pair, includes 18 additional data fields.

15 September 2008

NTPBSI: National Toxicology Program Bioassay On-line Database Structure-Index Locator File ** Updated to v4a
Corresponds to updated content of NTP website, with addition of 12 new records and studies.

15 August 2008

Expanded "link-in" options and user-defined limits to allow external websites to access DSSTox Structure Browser Search Results pages
Minimum of 10 structure similarity hits displayed regardless of similarity search threshold
New External Resources feature provides structure-based "link-outs" to public on-line resources, such as PubChem, ChemSpider, and Lazar In Silico Toxicology ; (link-out to EPA ACToR coming soon, est. Sept. 2008)
Structure "hit" resubmit feature, from either text or structure search, to faciliate structure look-up and searching.