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Sponsored by: |
Assistance Publique Hopitaux De Marseille |
Information provided by: | Assistance Publique Hopitaux De Marseille |
ClinicalTrials.gov Identifier: | NCT00731016 |
We suggest treating the Hutchinson-Gilford Progeria Syndrome by two molecules (zoledronic acid and pravastatin).The therapeutic approach which we propose has for objectives to reduce, to prevent or to delay the gravest infringements of the disease, to prolong the life of the children, and in a more general way, aim at improving their living conditions.
Condition | Intervention | Phase |
Hutchinson-Gilford Progeria Syndrome |
Drug: Zoledronic acid, pravastatin |
Phase II |
Genetics Home Reference related topics: | Hutchinson-Gilford progeria syndrome |
Drug Information available for: | Pravastatin Pravastatin sodium Zoledronic acid Sodium chloride S 1 (Combination) |
Study Type: | Interventional |
Study Design: | Treatment, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study |
Official Title: | Treatment of the Hutchinson-Gilford Progeria Syndrome With a Combination of Pravastatin and Zoledronic Acid |
Estimated Enrollment: | 15 |
Study Start Date: | October 2008 |
Estimated Study Completion Date: | March 2013 |
Estimated Primary Completion Date: | September 2012 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
1
Zoledronic acid, pravastatin
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Drug: Zoledronic acid, pravastatin
Pravastatin : 10 mg daily Zoledronic acid : slow (30 mn) intravenous injections, diluted into 50 ml of saline solution following this schedule :
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Ages Eligible for Study: | 3 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Nicolas LEVY, MD | 0491387787 | nicolas.levy@ap-hm.fr |
Contact: Sabine SIGAUDY, MD | 04 91 3867 49 | sabine.sigaudy@ap-hm.fr |
France | |||||
Laboratoire de Génétique Moléculaire - Hopital de la Timone | Recruiting | ||||
MARSEILLE, France, 13385 | |||||
Contact: Nicolas LEVY, MD 049138 77 87 nicolas.levy@ap-hm.fr | |||||
Contact: Sabine SIGAUDY, MD 04 91 3867 49 sabine.sigaudy@ap-hm.fr |
Assistance Publique Hopitaux De Marseille |
Principal Investigator: | Nicolas LEVY, MD | Assistance Publique des Hopitaux de Marseille |
Responsible Party: | Assistance Publique Hopitaux De Marseille ( Assistance Publique Hopitaux De Marseille ) |
Study ID Numbers: | 2008-002471-27, 2008-15 |
First Received: | August 1, 2008 |
Last Updated: | October 8, 2008 |
ClinicalTrials.gov Identifier: | NCT00731016 |
Health Authority: | France: Ministry of Health |
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