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Sponsored by: |
University of Pittsburgh |
Information provided by: | University of Pittsburgh |
ClinicalTrials.gov Identifier: | NCT00295087 |
Women who are affected with premature ovarian failure will exhibit skewed X-chromosome inactivation patterns compared to women with normal menstrual function (as defined by being pregnant), indicating a possible X-chromosome defect.
Condition |
Premature Ovarian Failure |
MedlinePlus related topics: | Premature Ovarian Failure |
Study Type: | Observational |
Study Design: | Cohort, Cross-Sectional |
Official Title: | X-Chromosome Inactivation Status and Premature Ovarian Failure |
DNA that is extarcted from the blood specimen
Estimated Enrollment: | 40 |
Study Start Date: | November 2005 |
Estimated Study Completion Date: | November 2008 |
Estimated Primary Completion Date: | November 2008 (Final data collection date for primary outcome measure) |
Premature ovarian failure (POF) affects approximately 1% of women. For most women a cause is not found, but structural abnormalities of the X-chromosome commonly lead to POF, suggesting genes on the X-chromosome are necessary for normal ovarian function. It is known that certain gene mutations on the X-chromosome can lead to changes in the normal random pattern of X-chromosome inactivation in females.
We propose to study X-inactivation patterns in a cohort of women with idiopathic POF, and compare their pattern to a mean age-matched cohort of women with normal menstrual function.
We hypothesize that some women with POF will show skewed X-inactivation, suggesting a mutation on the X-chromosome as the etiology of their POF.
Ages Eligible for Study: | 20 Years to 40 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Study population will include women diagnosed with POF through clinics. Women diagnosed with POF may also inquire about this study through the Clinical Trials website.
Inclusion Criteria:
Exclusion Criteria:
Contact: Heather A Huber, BS | 412-641-6063 | rsihah@mwri.magee.edu |
United States, Pennsylvania | |||||
Magee-Womens Hospital | Recruiting | ||||
Pittsburgh, Pennsylvania, United States, 15213 | |||||
Contact: Heather A Huber, BS 412-641-6063 rsihah@mwri.magee.edu | |||||
Contact: W. Allen Hogge, MD 412-641-4212 whogge@mail.magee.edu | |||||
Principal Investigator: W. Allen Hogge, MD | |||||
Sub-Investigator: Joseph S Sanfilippo, MD, MBA |
University of Pittsburgh |
Principal Investigator: | W. Allen Hogge, MD | University of Pittsburgh and Magee-Womens Hospital |
Responsible Party: | University of Pittsburgh/Magee-Womens Hospital ( W. Allen Hogge, MD ) |
Study ID Numbers: | 0511043 |
First Received: | February 17, 2006 |
Last Updated: | August 5, 2008 |
ClinicalTrials.gov Identifier: | NCT00295087 |
Health Authority: | United States: Institutional Review Board |
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