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Sponsors and Collaborators: |
Imperial College London Medical Research Council Laboratories, Gambia Government of the Gambia London School of Hygiene and Tropical Medicine Partnership for Child Development Wellcome Trust |
Information provided by: | Imperial College London |
ClinicalTrials.gov Identifier: | NCT00294580 |
A trial was conducted in the 1980s to compare two strategies for control of malaria in young children aged 3-59 months: treatment with chloroquine versus treatment combined with fortnightly chemoprophylaxis with Maloprim. The impact on mortality and morbidity was assessed at the time, and their cognitive abilities and educational outcomes were assess 14 years later in 2001. The hypothesis was that the chemoprophylaxis would reduce morbidity and mortality and would improve cognitive abilities and educational outcomes in the long term
Condition | Intervention | Phase |
Malaria |
Drug: Maloprim |
Phase IV |
MedlinePlus related topics: | Malaria |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Efficacy Study |
Official Title: | Comparison of Two Strategies for Control of Malaria Within A Primary Health Care Programme in the Gambia |
Estimated Enrollment: | 2253 |
Study Start Date: | April 1982 |
Estimated Study Completion Date: | September 2001 |
Two drug strategies for the control of malaria in children aged 3-59 months have been compared in a rural area of The Gambia - treatment of presumptive episodes of clinical malaria with chloroquine by village health workers, and treatment combined with fortnightly chemoprophylaxis (pyrimethamine/dapsone) which was also given by village health workers. Treatment alone did not have any significant effect on mortality or morbidity from malaria. In contrast, treatment and chemoprophylaxis reduced overall mortality in children aged 1-4 years, mortality from probable malaria, and episodes of fever associated with malaria parasitaemia. A high level of compliance with chemoprophylaxis was obtained and no harmful consequences of chemoprophylaxis were observed. Chemoprophylaxis was offered to all children at the end of the trial.
14 years after the end of the trial, participants cognitive abilities and educational attainment were assessed. Associations have been found between malaria infection and poor cognitive ability but causality has not yet been demonstrated through preventative trials and the long-term impact of malaria has not been investigated. 1190 children who had participated in the original trial for at least one year were targetted for follow-up. 579 were traced. Those who had received chemoprophylaxis attended school for 0.52 years more than the placebo group (p=.069). There was no overall effect on cognitive abilities but there was a significant treatment effect for cohorts that had not received chemoprophylaxis at the end of the trial or who had received less than one year of post-trial prophylaxis
Ages Eligible for Study: | 3 Months to 59 Months |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Gambia, Central River Division | |||||
Medical Research Council Field Station | |||||
Farafenni, Central River Division, Gambia |
Imperial College London |
Medical Research Council Laboratories, Gambia |
Government of the Gambia |
London School of Hygiene and Tropical Medicine |
Partnership for Child Development |
Wellcome Trust |
Principal Investigator: | Brian M Greenwood, MD | London School of Hygiene and Tropical Medicine |
Principal Investigator: | Matthew CH Jukes, DPhil | Imperial College London |
Study ID Numbers: | SCC-795-835 |
First Received: | February 20, 2006 |
Last Updated: | March 20, 2006 |
ClinicalTrials.gov Identifier: | NCT00294580 |
Health Authority: | Gambia: MRC Ethics Committee |
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