New CDC MMWR article, The Impact of Expanded Newborn Screening – United States 2006, published in the September 19th issue.
	NIH is now accepting applications for projects that will broaden the pharmacogenomics evidence-base for use in clinical decision-making. Read the announcement.
	September is National Ovarian Cancer Awareness Month. Read the new issue of Spotlight, (503 KB) an on-line newsletter produced by the University of Washington Center for Genomics and Public Health. Learn more about ovarian cancer from the CDC and NIH.
	What's New in HuGE September 2008

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses Bertram L & Tanzi RE Nat Rev Neurosci 2008 Oct;9(10):768-78

New Powerful Approaches for Family-based Association Tests with Longitudinal Measurements
Ding X, et al.
Ann Hum Genet 2008 Sep

Managing hereditary gastrointestinal cancer syndromes: the partnership between genetic counselors and gastroenterologists
Rubinstein WS & Weissman SM
Nat Clin Pract Gastroenterol Hepatol 2008 Sep

Do Single Nucleotide Polymorphisms in Xenobiotic Metabolizing Genes Determine Breast Cancer Susceptibility and Treatment Outcomes?
Singh V, et al.
Cancer Invest 2008 Sep:1

Being 'at-risk' for developing cancer: cognitive representations and psychological outcomes
Shiloh S, et al.
J Behav Med 2008 Sep

Polymorphisms of the Toll-like receptor 4 gene and their potential role in infectious diseases and chronic inflammatory disorders
Reismann P, et al.
Orv Hetil 2008 Sep;149(38):1791-9

Designing pharmacogenetic projects in industry: practical design perspectives from the Industry Pharmacogenomics Working Group
Bromley CM, et al.
Pharmacogenomics J 2008 Sep

Pharmacogenetics in drug discovery and development: a translational perspective
Roses AD
Nat Rev Drug Discov 2008 Sep

Population genetic screening for hereditary haemochromatosis: are we a step closer?
Allen KJ
Med J Aust 2008 Sep;189(6):300-1

Pharmacogenetics of Major Depression : Insights from Level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Trial
Lekman M, et al.
Mol Diagn Ther 2008;12(5):321-30

Testing Association with Interactions by Partitioning Chi-Squares
Yang Y, et al.
Ann Hum Genet 2008 Sep

The impact of individual and methodological factors in the variability of response to methylphenidate in ADHD pharmacogenetic studies from four different continents
Polanczyk G, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Sep

A family history of type 2 diabetes is associated with glucose intolerance and obesity-related traits with evidence of excess maternal transmission for obesity-related traits in a South East Asian population
Tan JT, et al.
Diabetes Res Clin Pract 2008 Sep

Perceived family history risk and symptomatic diagnosis of prostate cancer: the North Carolina Prostate Cancer Outcomes study
Spain P, et al.
Cancer 2008 Sep

Family history of Crohn's disease is associated with an increased risk for Crohn's disease of the pouch
Shen B, et al.
Inflamm Bowel Dis 2008 Sep

 

Evaluating the performance of models for predicting the BRCA germline mutations in Han Chinese familial breast cancer patients
Rao NY, et al.
Breast Cancer Res Treat 2008 Sep

Hereditary diffuse gastric cancer: implications of genetic testing for screening  and prophylactic surgery
Cisco RM, et al.
Cancer 2008 Sep;113(S7):1850-6

Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13
Burkhardt R, et al.
Arterioscler Thromb Vasc Biol 2008 Sep

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending September 24, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page