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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
September 25, 2008
Volume 21, No. 13

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.

Gene Variant Frequency

CTG repeats at the myotonic protein kinase gene in a healthy Chilean population sample
Amenabar F, et al.
Acta Neurol Scand 2008 Sep

 

Infectious and Parasitic Diseases

Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer
Moura SB, et al.
Microbes Infect 2008 Sep

Polymorphisms of microsomal triglyceride transfer protein in different hepatitis  B virus-infected patients
Yang ZT, et al.
World J Gastroenterol 2008 Sep;14(35):5454-60

 

Neoplasms

Genetic polymorphisms in the MMP-7 gene and breast cancer survival
Beeghly-Fadiel A, et al.
Int J Cancer 2008 Sep

Association of Common PALB2 Polymorphisms with Breast Cancer Risk: A Case-Control Study
Chen P, et al.
Clin Cancer Res 2008 Sep;14(18):5931-7

Coffee consumption, genetic susceptibility and bladder cancer risk
Villanueva CM, et al.
Cancer Causes Control 2008 Sep

TGF-beta1 genotypes in cirrhosis: Relationship with the occurrence of liver cancer
Falleti E, et al.
Cytokine 2008 Sep

The Influence of Interstitial Collagenas-1 Genotype Polymorphism on Colorectal Cancer Risk in Iranian Population
Kouhkan F, et al.
Cancer Invest 2008 Sep:1

Common genetic polymorphisms of AURKA and prostate cancer risk
Feik E, et al.
Cancer Causes Control 2008 Sep

Impact of ifn- g gene polimorphism on the risk of cervical cancer
Kordi Tamandani MK, et al.
Exp Oncol 2008 Sep;30(3):224-9

A nonsense mutation (E1978X) in the ATM gene is associated with breast cancer
Bogdanova N, et al.
Breast Cancer Res Treat 2008 Sep

Concomitant presence of mutations in mitochondrial genome and p53 in cancer development-A study in north Indian sporadic breast and esophageal cancer patients
Gochhait S, et al.
Int J Cancer 2008 Sep

Systemic inflammatory response predicts prognosis in patients with advanced-stage colorectal cancer
Sharma R, et al.
Clin Colorectal Cancer 2008 Sep;7(5):331-7

Frequency and Distinctive Spectrum of KRAS Mutations in Never Smokers with Lung Adenocarcinoma
Riely GJ, et al.
Clin Cancer Res 2008 Sep;14(18):5731-4

Impaired tamoxifen metabolism reduces survival in familial breast cancer patients
Newman WG, et al.
Clin Cancer Res 2008 Sep;14(18):5913-8

No association between the arg194trp and arg399gln polymorphisms of the xrcc1 gene and colorectal cancer risk and progression in a polish population
Sliwinski T, et al.
Exp Oncol 2008 Sep;30(3):253-4

Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol  drinking on the risk of lung cancer in Koreans
Eom SY, et al.
Cancer Causes Control 2008 Sep

 

Endocrine, Nutritional and Metabolic Diseases

p53 codon 72 proline/arginine polymorphism and autoimmune thyroid diseases
Chen RH, et al.
J Clin Lab Anal 2008 Sep;22(5):321-6

Polymorphisms in advanced glycosylation end product-specific receptor (AGER) gene, insulin resistance, and type 2 diabetes mellitus
Goulart AC, et al.
Clin Chim Acta 2008 Sep

Polymorphisms of the endothelial nitric oxide synthase gene in premenopausal women with polycystic ovary syndrome
Walch K, et al.
Maturitas 2008 Sep

 

Mental Disorders

Variation in the genes encoding vesicular monoamine transporter 2 and beta-1 adrenergic receptor and antidepressant treatment outcome
Crowley JJ, et al.
Psychiatr Genet 2008 Oct;18(5):248-51

Plasminogen activator inhibitor-1 gene is associated with major depression and antidepressant treatment response
Tsai SJ, et al.
Pharmacogenet Genomics 2008 Oct;18(10):869-75

Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression
Wray NR, et al.
Psychiatr Genet 2008 Oct;18(5):219-25

Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population
Grigoroiu-Serbanescu M, et al.
Psychiatr Genet 2008 Oct;18(5):240-7

Association between the A-1438G polymorphism of the serotonin 2A receptor gene and nonimpulsive suicide attempts
Saiz PA, et al.
Psychiatr Genet 2008 Oct;18(5):213-8

A common haplotype at the dopamine transporter gene 5' region is associated with  attention-deficit/hyperactivity disorder
Genro JP, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Sep

Risk for Depression During Interferon-Alpha Treatment Is Affected by the Serotonin Transporter Polymorphism
Lotrich FE, et al.
Biol Psychiatry 2008 Sep

A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder
Roecklein KA, et al.
J Affect Disord 2008 Sep

P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients
Nagy G, et al.
Prog Neuropsychopharmacol Biol Psychiatry 2008 Sep

Cultural consonance, a 5HT2A receptor polymorphism, and depressive symptoms: A longitudinal study of gene x culture interaction in urban Brazil
Dressler WW, et al.
Am J Hum Biol 2008 Sep

Polymorphic variants of genes encoding MTHFR, MTR, and MTHFD1 and the risk of depression in postmenopausal women in Poland
Slopien R, et al.
Maturitas 2008 Sep

Association of the dopamine transporter (SLC6A3/DAT1) gene 9-6 haplotype with adult ADHD
Franke B, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Sep

Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia
Edwards TL, et al.
Schizophr Res 2008 Sep

Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population
Gonda X, et al.
Eur Arch Psychiatry Clin Neurosci 2008 Sep

Detailed analysis of the serotonin transporter gene (SLC6A4) shows no association with bipolar disorder in the Northern Swedish population
Alaerts M, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Sep

Serotonin 5-HT(2A) receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression
Benedetti F, et al.
Prog Neuropsychopharmacol Biol Psychiatry 2008 Sep

COMT Val(158)Met moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life
Henquet C, et al.
Acta Psychiatr Scand 2008 Sep

Association between Catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in Adults
Halleland H, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Sep

 

Diseases of the Nervous System and Sense Organs

Population-based association study and contrasting linkage disequilibrium pattern reveal genetic association of SLC6A4 with autism in the Indian population from West Bengal
Guhathakurta S, et al.
Brain Res 2008 Sep

Mitochondrial DNA haplogroups and subhaplogroups are associated with Parkinson's  disease risk in a Polish PD cohort
Gaweda-Walerych K, et al.
J Neural Transm 2008 Sep

Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: Importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients
Floris G, et al.
Parkinsonism Relat Disord 2008 Sep

Analysis of rare variants in the complement component 2 (C2) and Factor B (BF) genes refine association for age-related macular degeneration (AMD)
Richardson AJ, et al.
Invest Ophthalmol Vis Sci 2008 Sep

An APOA1 promoter polymorphism is associated with cognitive performance in patients with multiple sclerosis
Koutsis G, et al.
Mult Scler 2008 Sep

Further assessment of the Complement Component 2 and Factor B region associated with Age-related Macular Degeneration
McKay GJ, et al.
Invest Ophthalmol Vis Sci 2008 Sep

 

Diseases of the Circulatory System

Single Nucleotide Polymorphisms Associated with Coronary Heart Disease Predict Incident Ischemic Stroke in the Atherosclerosis Risk in Communities Study
Morrison AC, et al.
Cerebrovasc Dis 2008 Sep;26(4):420-4

Type and Location of Venous Thromboembolism in Carriers of Factor V Leiden or Prothrombin G20210A Mutation Versus Patients With No Mutation
Kovac M, et al.
Clin Appl Thromb Hemost 2008 Sep

HFE mutations in heart disease
Dunn T, et al.
Heart Vessels 2008 Sep;23(5):348-55

The impact of the PAI-1 4G/5G polymorphism on the outcome of patients with ALI/ARDS
Tsangaris I, et al.
Thromb Res 2008 Sep

Polymorphisms of Homocysteine Metabolism Are Associated with Intracranial Aneurysms
Semmler A, et al.
Cerebrovasc Dis 2008 Sep;26(4):425-9

TNF{beta}+250 polymorphism and hyperdynamic state in cardiac surgery with cardiopulmonary bypass
Iribarren J, et al.
Interact Cardiovasc Thorac Surg 2008 Sep

Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease
Shanker J, et al.
Lipids Health Dis 2008 Sep;7(1):33

Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis
Djuric T, et al.
Clin Biochem 2008 Sep

Longitudinal Changes in Triglycerides According to ANGPTL4[E40K] Genotype and Longitudinal Body Weight Change in the Atherosclerosis Risk in Communities Study
Nettleton JA, et al.
Ann Epidemiol 2008 Sep

Association of the matrix metalloproteinase-3 (-439C/G) promoter polymorphism with Kawasaki disease in Korean children
Hong YM, et al.
Heart Vessels 2008 Sep;23(5):341-7

 

Diseases of the Respiratory System

A Common Exonic Variant of Interleukin21 Confers Susceptibility to Atopic Asthma
Chatterjee R, et al.
Int Arch Allergy Immunol 2008 Sep;148(2):137-46

Gene polymorphisms of IL-6(-174) G/C and IL-1Ra VNTR in Egyptian asthmatic children
Settin A, et al.
Indian J Pediatr 2008 Sep

 

Diseases of the Digestive System

Cathepsin C Gene Variants in Aggressive Periodontitis
Noack B, et al.
J Dent Res 2008 Oct;87(10):958-63

Association of genetic profiles to Crohn's disease by linear combinations of single nucleotide polymorphisms
D'Addabbo A, et al.
Artif Intell Med 2008 Sep

The IL-10R1 S138G loss-of-function allele and ulcerative colitis
Grundtner P, et al.
Genes Immun 2008 Sep

Six new celiac disease loci replicated in an Italian population confirm association to celiac disease
Romanos J, et al.
J Med Genet 2008 Sep

Role of host interleukin 1beta gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in clinical outcomes in Helicobacter pylori-positive  Turkish patients with dyspepsia
Erzin Y, et al.
J Gastroenterol 2008;43(9):705-10

 

Complications of Pregnancy, Childbirth, and the Puerperium

Comparison of Thrombophilic Gene Mutations Among Patients Experiencing Recurrent  Miscarriage and Deep Vein Thrombosis
Coulam CB, et al.
Am J Reprod Immunol 2008 Sep

 

Diseases of the Musculoskeletal System and Connective Tissue

HLA polymorphism and early rheumatoid arthritis in the Moroccan population
Atouf O, et al.
Joint Bone Spine 2008 Sep

Tumor Necrosis Factor alpha-308 and -238 Polymorphisms in Rheumatoid Arthritis. Association With Messenger RNA Expression and sTNF-alpha
Oregon-Romero E, et al.
J Investig Med 2008 Sep

Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs  gene polymorphisms)
Barlas IO, et al.
Rheumatol Int 2008 Sep

Genetic Variants of the IL-23R Pathway: Association with Psoriatic Arthritis and  Psoriasis Vulgaris, but No Specific Risk Factor for Arthritis
Huffmeier U, et al.
J Invest Dermatol 2008 Sep

Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of STAT1-STAT4 region
Kawasaki A, et al.
Arthritis Res Ther 2008 Sep;10(5):R113

 

Congenital Anomalies

Construction of a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population
Pangilinan F, et al.
Am J Med Genet A 2008 Sep

 

Certain Conditions Originating in the Perinatal Period

Association of dopamine transporter and monoamine oxidase molecular polymorphisms with sudden infant death syndrome and stillbirth: new insights into the serotonin hypothesis
Filonzi L, et al.
Neurogenetics 2008 Sep

 

Symptoms, Signs and Ill-defined Conditions

World-class performance in lightweight rowing: Is it genetically influenced? A comparison with cyclists, runners and non-athletes
Muniesa CA, et al.
Br J Sports Med 2008 Sep

 

Injury and Poisoning

Lack of association of delta-aminolevulinic acid dehydratase genotype with blood  lead levels in environmentally exposed children of Uygur and Han populations
Chen Y, et al.
Acta Paediatr 2008 Sep

 

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Page last reviewed: September 25, 2008 (archived document)
Content Source: National Office of Public Health Genomics