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 Thursday, October 4, 2007 Volume 19   Number 14
Weekly Update banner Family History Population Research Genomics in Practice General Public Family History Population Research Genomics in Practice General Public Family History Population Research Genomics in Practice General Public
  This weekly update provides information about the impact of human genetic research on disease prevention & public health. open mailbox for email deliveryGet email updates
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blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
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 Upcoming Events

Genetics and Personalized Medicine: The Future is Now non-gov warning icon

October, National Human Genome Research Institute non-gov warning icon

Pharmacogenomics non-gov warning icon (last accessed 2/2008)



 Let's Go Surfing
Framingham SNP Health Association Resource (SHARe) non-gov warning icon

Know Your Family Health History  non-gov warning icon

Databases at the EBI (European Bioinformatics Institute) non-gov warning icon

 

mother and daughter

When is BRCA Genetic Testing for Breast and Ovarian Cancer Appropriate?
The U.S. Preventive Services Task Force (USPSTF) recommends against routine referral for BRCA testing if a woman’s

family history does not suggest an increased risk for harmful BRCA mutations. The USPSTF recommends that women with a family history associated with an increased risk for BRCA mutations be referred to suitably trained health care providers.
Read the USPSTF recommendations and clinical considerations.

Genomics Announcements
   
CDC-sponsored event

New article, Family History and Prevalence of Diabetes in the U.S. Population: The 6-year results from the National Health and Nutrition Examination Survey (1999–2004)non-gov warning icon published in the October 2007 issue of Diabetes Care. Authors: Valdez R, Yoon PW, Liu T and Khoury MJ

   
CDC-sponsored event
New HuGE publication, Assessment of Cumulative Evidence on Genetic Associations: Interim Guidelines, published in the September 2007 issue of the International Journal of Epidemiology. Authors: Ioannidis JPA, Boffetta P, Little J, O’Brien TR, Uitterlinden AG, Vineis P, et al.
   
CDC-sponsored event

View remarks by HHS Secretary Michael O. Leavitt and presentations given at the 21st Century Medicine: Personalized and Evidence-Based  non-gov warning icon event hosted by the Personalized Medicine Coalition and Georgetown University School of Nursing & Health Studies on September 18-19, 2007.

   
CDC-sponsored event

Join the Mid-West Community Genetics Forum on Genomics, Community and Equity: A Continuing Dialogue non-gov warning icon presented by the University of Michigan, Center for Public Health and Community Genomics on October 12, 2007. Forums will be held in Illinois, Iowa, Michigan, Minnesota, and Missouri.


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

Gastric cancer trial seeks 'genetic fingerprint' for predicting drug effectivenessnon-gov warning icon Medical News Today, October 4

Genomic profiling of lung tumors helps doctors choose most effective treatmentnon-gov warning icon News-Medical.Net, September 30

Scientists identify six types of breast cancernon-gov warning icon The Independent, October 3

Researchers at IRB Barcelona discover one of the mechanisms that prevents the spread of colon cancernon-gov warning icon EurekAlert, September 30

Notch gene may lead to new methods of beating breast cancernon-gov warning icon News-Medical.Net, October 2

 

line

Ethical, Legal, and Social Issues (ELSI)

Genetics advances create ethical dilemmas, Sanford leader saysnon-gov warning icon ArgusLeader.com, September 28

line

Mental Health

Epilepsy in infants caused by genetic
mutation
non-gov warning icon Medical News Today, October 4

Genes tied to bad reactions to antidepressant
drug
,  non-gov warning icon New York Times, September 28

Genes linked to suicide risk in some patientsnon-gov warning icon NPR, September 28

Genetic test announced for suicidal ideation in patients using antidepressant drugsnon-gov warning icon EurekAlert, September 27

Schizophrenia candidate genes affect even healthy individualsnon-gov warning icon News-Medical.Net, September 28

Genes linked to suicidal thinking during antidepressant treatmentnon-gov warning icon NIH News, September 27

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Other News

PAZAR offers free shopping in a virtual bazaar of gene regulation datanon-gov warning icon Medical News Today, October 4

Mission impossible: A routine childhoodnon-gov warning icon The New York Times, September 30

First significant genetic finding in severe premenstrual dysphoric disordernon-gov warning icon News-Medical.Net, October 2

Toxic buildup in brain from loss of gene responsible for some dementiasnon-gov warning icon Medical News Today, September 30

Genetics and learningnon-gov warning icon News-Medical.Net, October 2

'Jumping genes' could make for safer gene delivery systemnon-gov warning icon Medical News Today, September 28

24 million Thais carry genetic trait for
thalassemia
non-gov warning icon News-Medical.Net, October 2

454 sequencing uncovers significant genetic variationnon-gov warning icon EurekAlert, September 27

Gene mutation tied to early-onset Parkinson diseasenon-gov warning icon (last accessed 2/2008) Reuters Health, October 1

Gene-hunting facility funded by federal 'genes and environment' grant, non-gov warning icon Medical News Today, September 27

Gene that lowers cell stress could protect against Parkinson's diseasenon-gov warning icon News-Medical.Net, October 1

Genetics Clinic Set for Oct. 13non-gov warning icon The Ellsworth American, September 27

microRNAs may be key to HIV's ability to hide, evade drugsnon-gov warning icon News-Medical.Net, October 1

Individual differences caused by shuffled chunks of DNA in the human genomenon-gov warning icon EurekAlert, September 27

NIH launches extensive open-access dataset of genetic and clinical datanon-gov warning icon NIH News, October 1

Successful strategies for probing genetic variation presented in new booknon-gov warning icon Medical News Today, September 27

Smoking is a turn-on for some genes: studynon-gov warning icon (last accessed 2/2008) Reuters Health, October 1

New group to study genetic link to drug risks, Reuters Health, September 27
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Genomics in Scientific Literature
Featured Item

The NCBI dbGaP database of genotypes and phenotypes
Mailman MD, et al.
Nat Genet 2007 Oct;39(10):1181-6

 General Articles

Effects of environment, genetics and data analysis pitfalls in an esophageal cancer genome-wide association study
Statnikov A, et al.
PLoS ONE 2007;2(9):e958

Genomics and the future of pharmacotherapy in psychiatry
Malhotra AK, et al.
Int Rev Psychiatry 2007 Oct;19(5):523-30

Contribution of hierarchical clustering techniques to the modeling of the geographic distribution of genetic polymorphisms associated with chronic inflammatory diseases in the Quebec population
Madore AM, et al.
Community Genet 2007;10(4):218-26

Genetic association studies; the good, the bad, and the ugly
Donahue MP & Kraus WE
Am Heart J 2007 Oct;154(4):610-2

Population attributable fraction: its implications for genetic epidemiology and illness prevention
Karp I, et al.
Am Heart J 2007 Oct;154(4):607-9

Beyond "misunderstanding": Written information and decisions about taking part in a genetic epidemiology study
Dixon-Woods M, et al.
Soc Sci Med 2007 Sep

Genetic epidemiology of primary sclerosing cholangitis
Karlsen TH, et al.
World J Gastroenterol 2007 Nov;13(41):5421-31

Genetic variation of estrogen metabolism and the risks of cardiovascular disease
Almeida S & Hutz MH
Curr Opin Investig Drugs 2007 Oct;8(10):814-20

Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues
Gage BF & Lesko LJ
J Thromb Thrombolysis 2007 Oct

The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
Cupples LA, et al.
BMC Med Genet 2007 Sep;8 Suppl 1:S1

 

 Genetic Testing

Danger zones: risk perceptions of young women from families with hereditary breast and ovarian cancer
Werner-Lin AV
Fam Process 2007 Sep;46(3):335-49

 

 Family History

Increased cancer risk for individuals with a family history of prostate cancer, colorectal cancer, and melanoma and their associated screening recommendations and practices
Noe M, et al.
Cancer Causes Control 2007 Sep

Genetics of migraine headache in children
Hershey AD
Curr Pain Headache Rep 2007 Oct;11(5):390-5

The presence of family history and the development of type 2 diabetes mellitus risk factors in rural children
Adams MH & Lammon CA
J Sch Nurs 2007 Oct;23(5):259-66

Modification of risk for subsequent cancer after female breast cancer by a family history of breast cancer
Hemminki K, et al.
Breast Cancer Res Treat 2007 Sep

Sociodemographic, Family History, and Lifestyle Risk Factors for Open-angle Glaucoma and Ocular Hypertension The Los Angeles Latino Eye Study
Doshi V, et al.
Ophthalmology 2007 Sep

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending October 3, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

 

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Page last reviewed: October 4, 2005 (archived document)
Content Source: National Office of Public Health Genomics