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 Thursday, June 21, 2007     Volume 18   Number 25  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on disease prevention & public health.
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Seeking Nominations for the EGAPP Stakeholders Group (ESG)
Nominations are requested for stakeholder representatives to participate in a stakeholders group that will work with the CDC-sponsored EGAPP pilot project. The deadline for nominations is July 18, 2007.
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blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
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Genomics Announcements
   
CDC sponsored material

New article on The emergence of biobanks: practical design considerations for large population-based studies of gene-environment interactions written by Robert L. Davis, MD, MPH and Muin Khoury, MD, PhD, was published in the June 2007 issue of Community Genetics

   

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CDC scientists use genetic analysis to track tuberculosis infection chain, story reported by National Public Radio non-gov warning icon

   
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Thirteenth Meeting of the Secretary’s Advisory Committee on Genetics, Health, and Society, July 10, 2007

   

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New website Telling Stories, Understanding Real-Life Genetics launched by an educational partnership in the United Kingdom non-gov warning icon


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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 Cancer

Study Tracks a Little-Explored Genetic Path of Breast Cancernon-gov warning icon New York Times, June 20

The unexpected connection of two gene regulation mechanisms points to new ways for the fight against leukemianon-gov warning icon Medical News Today, June 15

Detection of DNA copy number changes and oncogenic signaling abnormalities from gene expression data reveals MYC activation in renal cell carcinoma,  non-gov warning icon Medical News Today, June 18

Screening approach leads to discovery of gene linked to breast cancer,  non-gov warning icon EurekAlert, June 14

 

 Mental Disorders

Cause of Alzheimer seizures is soughtnon-gov warning icon Science Daily, June 19

On the Horizon, Personalized Depression Drugsnon-gov warning icon New York Times, June 19

 

 Other Chronic Diseases
Gene implicated in the development of cancer cells can be switched on using drugsnon-gov warning icon News-Medical.Net, June 17 Mayo Clinic researchers use 'genomic pathway' to predict Parkinson's,  non-gov warning icon EurekAlert, June 14

First gene linked to scoliosis identifiednon-gov warning icon Science Daily, June 15

 

 

 Family History
 Genetic Testing

Size of family structure could affect accuracy of predicting breast cancer risk for patients undergoing BRCA gene testing, JAMAnon-gov warning icon Medical News Today, June 20

Parents support genetic testing, DNA biobanks,  non-gov warning icon
Medical News Today, June 21

St. Jude shows gene test not needed if cancer drug given in low dosesnon-gov warning icon EurekAlert, June 19


 Other News

Gene may explain why some maltreated children develop behaviour problems, while others do not,  non-gov warning icon
Medical News Today, June 21

Human genetic 'deserts' are teeming with significant lifenon-gov warning icon EurekAlert, June 18

Gene-screening will be norm in 10 years, says DNA pioneer,  non-gov warning icon Guardian Unlimited, June 21

New understanding of how the DNA helix
replicates
,  non-gov warning icon News-Medical.Net, June 18

New research identifies five genetic themes crucial to keeping stem cells in a primitive, flexible state,  non-gov warning icon Medical News Today, June 20

Vical says gene-delivery product succeeds in trial,  non-gov warning icon (last accessed 2/2008) Reuters, June 18

Anti-cholesterol gene found in Italians,  non-gov warning icon Science Daily, June 20 Cell press announces new partnership with the American Society of Human Genetics,  non-gov warning icon Medical News Today, June 14
Researchers discover gene for rare skin disordernon-gov warning icon NIH News, June 20 Clocking in and out of gene expression,  non-gov warning icon EurekAlert, June 14

Answers to obesity may be in the genes,  non-gov warning icon Red Orbit, June 18

Study of N.L. genetic heritage prevents ailments,  non-gov warning icon CTV.ca, June 14

Health of babies not affected by embryo screening,  non-gov warning icon News-Medical.Net, June 18

US polygamist community faces rare genetic
disorder
non-gov warning icon (last accessed 2/2008) Reuters Health, June 14
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Genomics in Scientific Literature
Featured Item

A new multipoint method for genome-wide association studies by imputation of genotypes
Marchini J, et al.
Nat Genet 2007 Jun

 General Articles

Identification of Risk-Related Haplotypes with the Use of Multiple SNPs from Nuclear Families
Shi M, et al.
Am J Hum Genet 2007 Jul;81(1):53-66

Interest in genetic counseling and testing for adolescent nicotine addiction susceptibility among a sample of adolescent medicine providers attending a scientific conference on adolescent health
Tercyak KP, et al.
J Adolesc Health 2007 Jul;41(1):42-50

Genetic screening and disability insurance: what can we learn from the health insurance
experience?

Kass N & Medley A
J Law Med Ethics 2007 Summer;35(2 Suppl):66-73

Evaluation of polymorphisms known to contribute to risk for diabetes in African and African-American populations
Elbein SC
Curr Opin Clin Nutr Metab Care 2007 Jul;10(4):415-9

The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk
Tonjes A & Stumvoll M
Curr Opin Clin Nutr Metab Care 2007 Jul;10(4):410-4

ENPP1 gene, insulin resistance and related clinical outcomes
Bacci S, et al.
Curr Opin Clin Nutr Metab Care 2007 Jul;10(4):403-9

HNF4A genetic variants: role in diabetes
Love-Gregory L & Permutt MA
Curr Opin Clin Nutr Metab Care 2007 Jul;10(4):397-402

The new type 2 diabetes gene TCF7L2
Florez JC
Curr Opin Clin Nutr Metab Care 2007 Jul;10(4):391-6

Meta-analysis of genetic association studies under different inheritance models using data reported as merged genotypes
Salanti G & Higgins JP
Stat Med 2007 Jun

 

 Family History

Genetic epidemiology of BRCA mutations - family history detects less than 50% of the mutation carriers
Moller P, et al.
Eur J Cancer 2007 Jun

 

 Genetic Testing

Evaluating the clinical utility of a molecular genetic test for polycystic kidney disease
Garcia-Gonzalez MA, et al.
Mol Genet Metab 2007 Jun

Patients' understanding of genetic susceptibility testing in mainstream medicine: qualitative study on thrombophilia
Saukko PM, et al.
BMC Health Serv Res 2007 Jun;7(1):82

The roles of family members, health care workers, and others in decision-making processes about genetic testing among individuals at risk for Huntington disease
Klitzman R, et al.
Genet Med 2007 Jun;9(6):358-71

Genetic and environmental risk assessment for colorectal cancer risk in primary care practice settings: a pilot study
Myers RE, et al.
Genet Med 2007 Jun;9(6):378-84

Management Updates for Women with a BRCA1 or BRCA2 Mutation
Nusbaum R & Isaacs C
Mol Diagn Ther 2007;11(3):133-44

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending June 20, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases

Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

 

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 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: June 21, 2007 (archived document)
Content Source: National Office of Public Health Genomics