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(506KB)
Organized by
Muin J. Khoury, M.D., Ph.D.
National Office of Public Health Genomics
Centers for Disase Control and Prevention
Sponsor:
National Cancer Institute
Cosponsors: National Human Genome Research Institute, National Institute for Child Health and Development, and the Office of Behavioral and Social Sciences Research
In 2007, the CDC National Office of Public Health Genomics in collaboration with NCI conducted a monthly seminar series exploring various topics at the intersection of genomics, medicine and public health. The series explored the contributions of the multidisciplinary field of "public health genomics" to the translation of genomic discoveries into population health benefits. Webcasts, slides and selected readings are available below.
Session 1: January 18, 2007, 1-3pm, ENVISION-Koger Center, Williams Bld, Room 1805 |
What is “public health genomics” and why should we care? An overview of the series |
Speaker: Muin J. Khoury, CDC (slides
3.64MB) (videocast 49:56 min) |
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“Omics” 101 for medicine and public health |
Speaker: Stephen Chanock, NCI (1.02GB) |
Discussion: (slides
6.19MB) (videocast 1:08 min) |
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Session 2: February 15, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 1802/05 |
How do we assess the contribution of complex genotypes and gene-environment interaction to the population burden of common diseases? |
Introduction |
Speaker: Muin J. Khoury, CDC
(slides
642KB) |
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Cancer genetic epidemiology: what has worked and what has not worked? |
Speaker: Robert Hoover, NCI
(slides
925KB) (videocast including introduction by Muin Khoury 56:12 min) |
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Cohort studies and case-control studies in the era of whole genome associations |
Speaker: Teri Manolio, NHGRI (slides
1.29MB) (videocast 34:22 min) |
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Session 3: March 12, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 1802/05 |
What is the role of behavioral and social sciences in translating genetic research into population health benefits? |
Introduction |
Speaker: Muin J. Khoury, CDC
(slides
364KB) |
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Beyond Nature/Nurture: transdisciplinary approach to genomic, behavioral and social science research |
Speaker: David Abrams, Director NIH OBSSR
(slides
2.9MB) (videocast including introduction by Muin Khoury 57:53 min) |
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Using genomics to change health behavior |
Speaker: Colleen McBride, NHGRI
(slides
2.9MB) (videocast 48:12 min) |
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Session 4: April 19, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 2103 |
Knowledge integration in public health genomics: evaluation of the epidemiologic evidence |
Grading cumulative evidence, integrating biology, and developing online knowledge base |
Speaker: Muin J. Khoury, CDC
(slides
1.85MB)
(videocast
45:45 min) |
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Cancer example: Genetic polymorphisms, environmental exposures and bladder cancer |
Speaker: Nat Rothman, NCI
(slides
734.5KB)
(videocast
52:33 min) |
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- García-Closas M, Malats N, Silverman D, Dosemeci M, Kogevinas M, Hein DW, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Castaño-Vinyals G, Yeager M, Welch R, Chanock S, Chatterjee N, Wacholder S, Samanic C, Torá M, Fernández F, Real FX, Rothman N. NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. Lancet 2005; 366:649-59. ( 159.29kb)
- Ioannidis JPA, Gwinn M, Little J, Higgins JPT, Bernstein JL, Boffetta P, Bondy M, Bray MS, Brenchley PE, Buffler PA, Casas JP, Chokkalingam A, Danesh J, Smith GD, Dolan S, Duncan R, Gruis NA, Hartge P, Hashibe M, Hunter DJ, Jarvelin MR, Malmer B, Maraganore DM, Newton-Bishop JA, O'Brien TR, Petersen G, Riboli E, Salanti G, Seminara D, Smeeth L, Taioli E, Timpson N, Uitterlinden AG, Vineis P, Wareham N, Winn DM, Zimmern R, Khoury MJ. A road map for efficient and reliable human genome epidemiology. Nature Genetics 2006; 38:3-5. ( 124.24kb)
- Lin BK, Clyne M, Walsh M, Gomez O, Yu W, Gwinn M, Khoury MJ. Tracking the Epidemiology of Human Genes in the Literature: The HuGE Published Literature Database. Am J Epidemiol. 2006 Jul 1;164(1):1-4. ( 59.16kb)
- Seminara D, Khoury MJ, O'Brien TR, Manolio T, Gwinn ML, Little J, Higgins JP, Bernstein JL, Boffetta P, Bondy M, Bray MS, Brenchley PE, Buffler PA, Casas JP, Chokkalingam AP, Danesh J, Davey SG, Dolan S, Duncan R, Gruis NA, Hashibe M, Hunter D, Jarvelin MR, Malmer B, Maraganore DM, Newton-Bishop JA, Riboli E, Salanti G, Taioli E, Timpson N, Uitterlinden AG, Vineis P, Wareham N, Winn DM, Zimmern R, Ioannidis JP. The emergence of networks in human genome epidemiology: challenges and opportunities. Epidemiology 2007; 18(1):1-8. ( 291.89kb)
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Session 5: May 17, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 2103 |
Knowledge integration in public health genomics: evaluation of genetic and genomic tests |
A public health framework for genetic test evaluation |
Speaker: Muin J. Khoury, CDC (slides
1.51MB) (videocast 32:28 min) |
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Evidence-based Guidelines for the Evaluation
of Genomic Applications in Practice and Prevention |
Speaker: Al Berg, CDC (slides
3.81MB) (videocast 32:27 ) |
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Session 6: July 26, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 1802/05 |
But how do we translate new genetic knowledge into practice? |
How do we actually translate guidelines into action? |
Introduction |
Speaker: Muin J. Khoury, CDC
(slides 1.4MB) |
Speaker, Jon Kerner, NCI
(slides 1.6MB) (videocast 51 min) |
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What is the role of professional organizations, consumers, oversight and regulation? |
Speaker:
Kathy Hudson, Genetics and Public Policy Center, Johns Hopkins University (slides 2.4MB) (videocast 36:58 min) |
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- Hudson K. 2007. Prohibiting genetic discrimination. New England Journal of Medicine 356(20): 2021-2023. ( 125kb)
- Javitt G. and Hudson K. 2007. The right prescription for personalized genetic medicine. Personalized Medicine 4(2): 115-118. ( 164kb)
- Hudson K., Murphy J., Kaufman D., Javitt G., Katsanis S., and Scott J. 2006. Oversight of US genetic testing laboratories. Nature Biotechnology 24(9): 1083-1090. ( 195kb)
- Kerner J.F,Guirguis-Blake J., Hennessy K.D., Brounstein P.J., Vinson C., Schwartz R.H., Myers B.A., and Briss P. 2005. Translating research into improved outcomes in comprehensive cancer control. Cancer Causes and Control 16(Suppl. 1): 27-40. ( 274kb)
- Kerner J.F. 2006. Knowledge translation versus knowledge integration: a "funder’s" perspective. The Journal of Continuing Education in the Health Professions Vol. 26, 72-80. ( 187kb)
- Park E.R., Kleimann S., Shields A.E., and Pelan J.A. 2007. Anticipating clinical integration of genetically tailored tobacco dependence treatment: Perspectives of primary care physicians Nicotine & Tobacco Research, 9(2), 271 - 279 ( 255kb)
- Lerman C. and Shields A.E. 2004. Genetic testing for cancer susceptibility: the promise and the pitfalls Nature Reviews Cancer, 4(March), 235 - 241 ( 258kb)
- Parthasarathy S. 2005. Architectures of genetic medicine: comparing genetic testing for breast cancer in the USA and the UK. Social Studies of Science 35(1) 5-40 ( 2.86mb)
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Session 7: September 20, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 1802/05 |
How do we monitor the impact of genomics on population health? |
Role of public health agencies in assessing and assuring appropriate use of genomics in population health |
Speaker: Muin J. Khoury, CDC (slides 3MB) (videocast 32:37 min) |
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Applied research for genomic applications in clinical practice |
Speaker: Louise Wideroff, NCI (slides 135KB) (videocast 39:43 min) |
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- Beskow L, Khoury MJ, Baker TG, Thrasher J. The Integration of Genomics into Public Health Research, Policy, and Practice in the United States. Community Genetics 2001;4:2-11.
- Khoury MJ, McCabe L, McCabe ERB. Population screening in the age of genomic medicine.( 118kb) New Engl J Med 2003;348:50-58.
- Lindegren ML, Lyn S, Moore CA. The role of human genomics in acute public health investigations: current practice and future strategies. CDC Genomics and Population Health Report 2005.
- Goddard KAB, Moore C, Ottman D, Bradley L,Khoury MJ. Awareness and use of direct to consumer nutrigenomic tests, United States, 2006. ( 333kb) Genet Med 2007;9:510-517.
- Meropol NJ, Schulman KA. 2007. Cost of Cancer Care: Issues and Implications. ( 135kb) J Clin Oncol 25(2), 180-186.(pdf, 135kb)
- Genetic Tests for Cancer. Prepared for the Agency for Healthcare Research and Quality. ( 487kb)
- Hall MJ, Olopade OI. 2006. Disparities in Genetic Testing: Thinking Outside the BRCA Box. J Clin Oncol 24(14), 2197-2203. ( 105kb)
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Session 8: October 18, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 1802/05 |
Can we use family history as a tool for disease prevention and public health? |
Introduction |
Speaker: Muin J. Khoury, CDC
(slides
69.9KB) |
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The Surgeon General family history initiative: why is family history important in the genomics age? |
Speaker: Alan Guttmacher, NHGRI (slides 1.23MB)(videocast 35:49 min) |
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Family health history in the control and prevention of cancer, heart disease and diabetes |
Speaker: Paula Yoon, CDC (slides 1.62MB)(videocast 48:36 min) |
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- Guttmacher AE, Collins FS, Carmona RH. The family history--more important than ever. ( 71.1kb) New England Journal of Medicine 2004; Nov 25; 351(22):2333-6.
- Valdez R, Yoon PW, Liu T, Khoury MJ. Family history and prevalence of diabetes in the US population: 6-year results from the National Health and Nutrition Examination Survey (NHANES, 1999 2004). ( 120kb) Diabetes 2007; Jul 31 [Epub ahead of print]
- Valdez R, Greenlund KJ, Khoury MJ, Yoon PW. Is family history a useful tool for detecting children at risk for diabetes and cardiovascular diseases? A public health perspective. ( 272kb) Pediatrics 2007 Sep; 120 Suppl 2: S78-86.
- Scheuner MT, Whitworth WC, McGruder H, Yoon PW, Khoury MJ. Familial risk assessment for early-onset coronary
heart disease. ( 103kb) Genetics in Medicine 2006 Aug; 8(8):525-31.
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Session 9: November 29, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 1802/05 |
Genomics and the schism between basic sciences, medicine and public health |
Genomic medicine and health disparities |
Speaker: Charles Rotimi, Howard University (slides 1.02MB) (videocast 48:36 min) |
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Will genomics widen or help heal the schism between medicine and public health? |
Speaker: Muin J. Khoury, CDC (slides 2.29MB) (videocast 40:33 min) |
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- Khoury MJ, Gwinn M, Burke W, Bowen S, Zimmern R. Will Genomics Widen or Help Heal the Schism Between Medicine and Public Health? ( 116.76kb) Am J Prev Med 2007; 33(4); 310-3117.
- Scheumer MT, Whitworth WC, McGruder H, Yoon PW, Khoury MJ. Familial risk assessment for early-onset coronary heart disease. ( 323.76kb) Genet Med 2007:9(10):665-674.
- Foster MW and Sharp RR. Beyond race: towards a whole-genome perspective on human populations and genetic variation. ( 198kb) Nat Rev Genet 2004;5(10):790-796.
- Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, Xie X, Byrne EH, McCarroll SA, Gaudet R, Schaffner SF, Lander ES, & The International HapMap Consortium. Genome-wide detection and characterization of positive selection in human populations. ( 1mb) Nature 2007;449(7164):913-913.
- Rotimi CN. Are medical and nonmedical users of large-scale genomic markers conflating genetics and 'race'?. ( 118kb) Nat Genet 36(11 Suppl):S43-47.
- Genes, drugs and race. ( 52kb) Nat Genet 2001;29(3):239-240.
- Duster T. Race and Reification in Science. ( 110kb) Science 2005;307(5712):1050-1051.
- Slicing soup. ( 62kb) Nat Biotechnol 2002;20(7):637.
- Garcia RS. The Misuse of Race in Medical Diagnosis. ( 225kb) Pediatrics 2004;113:1394-1395.
- Sankar P, Cho MK, Mountain J. Race and Ethnicity in Genetic Research. ( 127 kb) Am J Med Genet A 2007;143(9):961-970.
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Provides link to non-governmental sites and does not necessarily represent the views of the Centers for Disease Control and Prevention. |
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Page last updated: December 11, 2007
Content Source: National Office of Public Health Genomics |
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