International Cooperation on Cosmetic Regulation:
Outcome of Meeting, September 26-28, 2007

Preparation for International Cooperation on Cosmetics Regulations Meeting in Brussels, Belgium (Federal Register Notice, August 13, 2007)

1. Good manufacturing practices ("GMP")

   ICCR recognises the importance of GMP and the need to work towards a common approach.

   ICCR commits to take ISO standard 22716 on GMP into due consideration when developing or updating guidelines or other measures addressing GMP.

   To this end,

   • The EU will adopt a European standard modelled after the respective ISO standard;
   • Canada will create GMP guidelines taking into consideration the ISO standard;
   • Japan will recognise the voluntary guidelines updated in the light of ISO;
   • U.S. will take into consideration the availability of the ISO standard as voluntary guidelines.
2. Ingredients labelling/INCI

   In response to industry's request to a harmonised approach to cosmetic ingredients labelling, ICCR invites the industry associations to generate and submit data substantiating that U.S. consumers understand the meaning of trivial names. Consumer groups should be involved in this process. Opportunity shall be given for ICCR to comment on the survey protocol.

3. Nanotechnology

   ICCR invites industry to

   • develop a common definition of nanotechnology in the field of cosmetics; and
   • set up an inventory of current application of nanotechnology in this field.

   ICCR will use this information in order to determine the path forward in this area.

4. Market surveillance

   ICCR acknowledges the need to keep each other apprised of emerging product-related safety issues.

5. Authorised substances

   ICCR acknowledges the wish of industry for global harmonisation of risk assessment. ICCR invites industry to submit proposals on the possible role of ICCR in this issue.

6. Animal testing and alternative methods

   ICCR recognized the importance of reducing, refining and replacing animal testing. The group welcomed the efforts of industry and validation centres in developing and validating scientific alternatives to animal testing.

   Intensive collaboration and communication in the design, execution, and peer review of validation studies should be further strengthened.

   ICCR invites ICCVAM, ECVAM, JaCVAM and a knowledgeable representative of the Government of Canada to address this issue and to propose options to ensure a collaborative approach to this issue. They should be supported by scientific experts from the regulatory bodies.