Primary Outcome Measures:
- Peak PTH and area under the curve for PTH measurement [ Time Frame: Measured at baseline and Month 12 ] [ Designated as safety issue: No ]
- Change in a modified XLH Disease Index (XDI) [ Time Frame: Measured at Month 12, compared with baseline ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Clinical parameters of height and blood pressure [ Time Frame: Measured at baseline and Month 12 ] [ Designated as safety issue: No ]
- Static parameters of serum alkaline phosphatase, CTx (resorption marker), PINP (bone turnover marker), 25-OH vitamin D, FGF7, FRP4 and MEPE (potential disease mediators), urinary calcium excretion, and TMP [ Time Frame: Measured at baseline and Month 12 ] [ Designated as safety issue: No ]
- Diurnal measure including serum Ca, P, PTH, 1,25 vitamin D, and FGF23 (intact and C-terminal) [ Time Frame: Measured at baseline and Month 12 ] [ Designated as safety issue: No ]
- Repeat bone scan [ Time Frame: Measured at baseline and Month 12 ] [ Designated as safety issue: No ]
- Repeat cardiac sonogram [ Time Frame: Measured at baseline and Month 12 ] [ Designated as safety issue: No ]
- Clinical questionnaire, SF-36v2 [ Time Frame: Measured at baseline and Month 12 ] [ Designated as safety issue: No ]
- Overall disease score on XDI [ Time Frame: Measured at baseline and Month 12 ] [ Designated as safety issue: No ]
XLH rickets is a rare inherited disorder in which the bones become painfully soft and bend easily because of a phosphate deficiency. This genetic defect causes the kidneys to allow excretion of an inappropriately high amount of phosphate into the urine. The kidneys are also unable to convert vitamin D into a form usable by the body, resulting in inadequate amounts of active vitamin D. Because vitamin D is needed to absorb calcium and phosphate from the intestine, this deficiency further reduces phosphate levels. Without the sufficient phosphate needed for normal bone growth, individuals with XLH rickets typically develop skeletal malformations, bone pain, and abnormally bowed legs. Hyperparathyroidism, a condition in which the parathyroid glands excrete excess amounts of PTH, also occurs frequently in individuals with XLH rickets, and may play a significant role in the skeletal complications associated with XLH rickets. The purpose of this study is to determine the effectiveness of paricalcitol in lowering PTH levels and reducing disease symptoms in individuals with XLH rickets.
This study will last 12 months. Participants will be randomly assigned to receive either paricalcitol or placebo, taken in the form of two pills daily for the duration of the study. During a baseline 3-day inpatient hospital stay, participants will undergo a physical exam, a cardiac ultrasound, a bone scan, blood collection, and a radiographic skeletal survey. The skeletal survey will include x-rays of various body parts. Participants who are 18 years or younger will not undergo the radiographic skeletal survey. Study visits for all participants will occur every 2 months until the end of the study. These visits will include a physical exam, review of disease symptoms, blood and urine collection, and a check of medication compliance.