|
2003 Assisted Reproductive Technology (ART) Report: Section 2—ART
Cycles Using Fresh, Nondonor Eggs or Embryos |
|
This
page contains figures 14–24
Section
2A | Section
2B | Section 2C
What
are the causes of infertility among couples who use ART?
Figure 14 shows the infertility
diagnoses reported among couples who had an ART procedure using fresh
nondonor eggs or embryos in 2003. Diagnoses range from one infertility
factor in one partner to multiple factors in either one or both partners.
However, diagnostic procedures may vary from one clinic to another, so the
categorization may be inexact.
-
Tubal factor means that the woman’s fallopian tubes are blocked or
damaged, making it difficult for the egg to be fertilized or for an embryo
to travel to the uterus.
-
Ovulatory dysfunction means that the ovaries are not producing eggs
normally. Such dysfunctions include polycystic ovary syndrome and multiple
ovarian cysts.
-
Diminished ovarian reserve means that the ability of the ovary to produce
eggs is reduced. Reasons include congenital, medical, or surgical causes
or advanced age.
-
Endometriosis involves the presence of tissue similar to the uterine
lining in abnormal
locations. This condition can affect both fertilization of the egg and
embryo implantation.
-
Uterine factor means a structural or functional disorder of the uterus
that results in
reduced fertility.
-
Male factor refers to a low sperm count or problems with sperm function
that make it difficult for a sperm to fertilize an egg under normal
conditions.
-
Other causes of infertility include immunological problems, chromosomal
abnormalities, cancer chemotherapy, and serious illnesses.
-
Unexplained cause means that no cause of infertility was found in either
the woman or the man.
-
Multiple factors, female only, means that more than one female cause was
diagnosed.
-
Multiple factors, female and male, means that one or more female
causes and male factor infertility were diagnosed.
Figure
14: Diagnoses Among Couples Who Had ART Cycles Using Fresh
Nondonor Eggs or Embryos, 2003.
|
|
Does the cause of infertility affect the
chances of success using ART?
Figure 15 shows the percentage
of live births after an ART procedure according to the causes of
infertility. (See
Figure 14 or the Glossary in
Appendix B for an explanation of the diagnoses.)
Although the national average success rate was slightly more than 28% (see
Figure 5), success rates varied
somewhat depending on diagnosis; however, the definitions of these
diagnoses may vary from clinic to clinic. In general, couples diagnosed
with tubal factor, ovulatory dysfunction, endometriosis, male factor, or
unexplained infertility had above-average success rates. The lowest
success rate was observed for those with diminished ovarian reserve.
Additionally, couples with uterine factor, “other” causes, or multiple
infertility factors had below-average success rates.
Figure
15: Live Birth Rates Among Women Who Had ART Cycles Using Fresh
Nondonor Eggs or Embryos, by Diagnosis, 2003.
|
|
How
many women who use ART have previously given birth?
Figure 16 shows the number of
previous births among women who had an ART procedure using fresh nondonor
eggs or embryos in 2003. Most of these women (about 73%) had no previous
births, although they may have had a pregnancy that resulted in a
miscarriage or an induced abortion. About 20% of women using ART in 2003
reported one previous birth, and 7% reported two or more previous births.
However, we do not have information about how many of these were ART
births and how many were not. These data nonetheless point out that women
who have previously had children can still face infertility problems.
Figure
16: Number of Previous Births Among Women Who Had ART Cycles Using
Fresh
Nondonor Eggs or Embryos, 2003. |
|
Do
women who have previously given birth have higher ART success rates?
Figure 17 shows the
relationship between the success of an ART cycle and the history of
previous births. Previous live-born infants were conceived naturally in
some cases and through ART in others. In all age groups up to age 42,
women who had a previous live birth were more likely to have a successful
ART procedure.
Figure
17: Live Birth Rates for ART Cycles Using Fresh Nondonor Eggs
or Embryos, by Woman's Age and Number of Previous Live Births, 2003. |
|
Is there a
difference in ART success rates between women with previous miscarriages
and women who have never been pregnant?
In 2003, 66,343 ART cycles were performed among women who
had not previously given birth (see
Figure
16). However, about 27% of those cycles were reported by women with
one or more previous pregnancies that had ended in miscarriage. We do not
have information on whether the previous pregnancies were the result of
ART or were conceived naturally.
Figure 18 shows the relationship between the success of an ART cycle
and the history of previous miscarriage. In all age groups women who had a
previous miscarriage had live birth rates that were comparable to the live
birth rates among women who had never been pregnant. Thus, a history of
unsuccessful pregnancy does not appear to be associated with reduced
chances for success during ART.
Figure 18: Live
Birth Rates for ART Cycles Using Fresh Nondonor Eggs or Embryos, by
Woman's Age and History of Miscarriage, Among Women with No Previous
Births, 2003.
|
|
How
many current ART users have undergone previous ART cycles?
Figure 19 presents ART cycles
that used fresh nondonor eggs or embryos in 2003 according to whether
previous ART cycles had been performed. For about 44%, one or more
previous cycles were reported. (This percentage includes previous cycles
using either fresh or frozen embryos.) This finding illustrates that it is
not uncommon for a couple to undergo multiple ART cycles. We do not have
information on when previous cycles were performed, nor do we have
information on the outcomes of those previous cycles.
Figure
19: Number of Previous ART Cycles Among Women Undergoing ART in 2003
with Fresh Nondonor Eggs or Embryos. |
|
Are success rates different for women
using ART for the first time and women who previously used ART but did
not give birth?
Figure 20 shows the
relationship between the success of ART cycles performed in 2003 using fresh
nondonor eggs or embryos and a history of previous ART cycles among women
with no previous births. In most age groups, success rates were lower for
women who had previously undergone an unsuccessful ART cycle.
Figure 20:
Live Birth Rates for ART Cycles Using Fresh Nondonor Eggs or Embryos, by
Woman's Age and History of Previous ART Cycles, Among Women with No
Previous Births, 2003. |
|
What
are the success rates for women who have had both previous ART and
previous births?
Figure 21 shows the
relationship between the success of ART cycles performed in 2003 using
fresh nondonor eggs or embryos and a history of both previous ART cycles
and previous births. We do not have information on whether the previous
births were the result of ART or were conceived naturally. However, among
women with previous births, there was no decline in success rates if they
had undergone previous ART cycles.
Taken together,
Figures 20 and
21
show that having undergone previous ART cycles may be related to the
success of the current ART cycle. However, it is important to consider the
outcomes of previous cycles and whether the woman has given birth in the
past.
Figure 21: Live
Birth Rates for ART Cycles Using Fresh Nondonor Eggs or Embryos, by
Woman's Age and History of Previous ART Cycles, Among Women with One or
More Previous Births, 2003.
|
|
What were the specific types of ART
performed among women who used fresh nondonor eggs or embryos in 2003?
For about 44% of ART procedures that used fresh nondonor eggs or embryos
in 2003, standard IVF (in vitro fertilization) techniques were used: eggs
and sperm were combined in the laboratory, the resulting embryos were
cultured for 2 or more days, and one or more
embryos were then transferred into the woman’s uterus through the cervix.
For more than half (56%) of ART procedures, fertilization was accomplished
using intracytoplasmic sperm injection (ICSI). This technique involves
injecting a single sperm directly into an egg; the embryos are then
cultured and transferred as in standard IVF.
For a small proportion of ART procedures, unfertilized eggs and sperm
(gametes) or early embryos (zygotes) were transferred into the
woman’s fallopian tubes. These procedures are known as gamete and zygote
intrafallopian transfer (GIFT and ZIFT). Some women with tubal infertility
are not suitable candidates for GIFT and ZIFT. GIFT and ZIFT are more
invasive procedures than IVF because they involve inserting a laparoscope
into a woman’s abdomen to transfer the embryos or gametes into the
fallopian tubes. In contrast, IVF involves transferring embryos or gametes
into a woman’s uterus through the cervix without surgery.
Figure 22:
Types of ART Procedures Using Fresh Nondonor Eggs or Embryos, 2003.
|
|
What are the success rates for
different types of ART procedures?
Figure 23 shows the percentage
of egg retrievals that resulted in a live birth for each type
of ART procedure started in 2003. Success rates for the two predominant
types of ART, IVF without ICSI and IVF with ICSI, were similar. The
success rates for cycles that used GIFT or ZIFT were much lower than for
cycles that used other ART procedures. See
Figures 24–26
for further details on IVF procedures that used ICSI.
Figure
23: Live Births per Retrieval for Different Types of ART Procedures
Using Fresh Nondonor Eggs or Embryos, 2003.
|
|
Is ICSI used only for couples diagnosed with male factor
infertility?
ICSI was developed to overcome problems with fertilization
that sometimes occur in couples diagnosed with male factor infertility. In
2003, 50,648 ICSI cycles were performed. Although the majority of couples
using ICSI had a diagnosis of male factor infertility, a sizable portion
of ICSI cycles (about 47%) were performed for couples without a
diagnosis of male factor infertility.
Figure
24: Use of ICSI in Fresh–Nondonor Cycles Among Couples with and
Without Diagnoses of Male Factor Infertility, 2003.
|
|
Section
1 | Section 2 |
Section
3 | Section 4 |
Section
5
Previous ART Reports
Implementation of the Fertility
Clinic Success Rate and Certification Act of 1992
Assisted Reproductive Technology: Embryo
Laboratory
Date last reviewed:
03/27/2006
Content source: Division
of Reproductive Health,
National Center for Chronic Disease
Prevention and Health Promotion
|
|
|