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At a glance: Administering
vaccines and other drugs through the skin without the use of
conventional needles. This page provides background
information, scientific bibliography, history, and links to
news reports, policy sources, device manufacturers, and
related sites about this method that overcomes the drawbacks
of needles for injections. |
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Bibliography, manufacturers, and patents |
Bibliography of
scientific literature, manufacturers roster, and patent
list (document Jetinject-Bib; last updated 2006-August-31)
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of Page
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R&D funding
sources |
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FDA Center for Devices and Radiological
Health (CDRH) |
Center for Devices and Radiological Health
(CDRH), Food and Drug Administration
(FDA)
- General Hospital and Personal
Use Devices Panel of the Medical Devices Advisory
Committee - meeting on needle-free devices and
jet injectors, 2 Augiust 1999:
- CDRH Assistance for
Small Manufacturers
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International Organization for Standardization
(ISO) |
International Organization for Standardization
(ISO) working group
on needle-free injectors for medical use (ISO/TC 84/WG3
ad hoc 5) (Contact via email: Convenor,
Robert R. Nesbitt, or Secretary,
Lars Brogaard. Convenor emeritus: Paul Jansen)
- N4 - List of members (Jul
1999) (.pdf 11Kb) (.doc 39Kb, see N15)
- N13 - List of members (Oct
1999) (.pdf 14Kb) (.doc 125Kb, see N15)
- N15 - List of members (Jan
2000) (.doc 22kB, supersedes N4, N13)
- 2001-June-20: Document ISO/AWI 21649 ("Needle-free
injectors for medical use -- Requirements and test
methods") by Working
group 4 (TC 84/WG 4) passed Preliminary (00)
and Proposal stages (10), and approved as a
new project (stage 10.99)
- 2001-June: Draft
standards moved to Preparatory stage / Registration
substage 20.00 under ISO
Technical Committee 84 (TC 84) "Medical devices for
injections"
- 2003-February: "Progress
Towards Developing Standards for Needle-free Injectors
for Medical Use": Powerpoint® presentation
explaining process and status of draft standard, by
working group Convenor,
Robert R. Nesbitt, at 8th International Conference
on Needle-free and Auto Injectors, London, 24-25 February
2003.
- 2003-March: Draft International
Standard, Stage 4, in process of 5-month circulation
to all member organizations/countries of ISO for comments.
Contact Convenor
or Secretary
for copy and instructions for submitting comments
through your national standards organization.
- Meetings:
- Toronto, 3 June 1999
- Minneapolis, 19-21 October
1999
- London,
1-2 March 2000
- Conference calls (Atlanta
node), 17 April, 4 May 2000
- Stockholm, 16-17 May
2000
- Washington, DC, 14-15
September 2000
- Lisbon, 22-23 January
2001
- Portland, Oregon, 11-12
July 2001
-
Copenhagen,
Denmark, 3-4 December 2001
- Franklin
Lakes, NJ, USA, 8-9 April 2002
- Reykjavik,
Iceland, 19-20 August 2002
- Orlando,
Florida, USA, 27 January 2003
- Scottsdale,
Arizona, USA, 2-3 February 2004
- Indianapolis,
Indiana, USA, 22-23 June 2005
- 2006-Jan-Mar:
Draft International Standard ISO 21649 submitted to
member bodies for final approval.
- 2006-June-1: Final
publication as international standard "ISO
21649 Needle-free injectors for medical use -- Requirements
and test methods"
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Policies (WHO, CDC, DoD) |
- World Health Organization (WHO)
needle-free injection policy
- Centers for Disease Control and
Prevention (CDC)
needle-free injection policy
- 2002 - General Recommendations
on Immunization: Recommendations of the Advisory
Committee on Immunization Practices (ACIP) and
the American Academy of Family Physicians.
MMWR, 8 February 2002; Vol. 51 (No. RR-2);1-36
(see pp. 12-13) official .pdf version
unofficial .htm version
- 1994 - General Recommendations
on Immunization: Recommendations of the Advisory
Committee on Immunization Practices (ACIP),
MMWR, 28 January 1994; Vol. 43 (RR01);1-38
(see pp. 7-8) official .pdf version
(443Kb)
unofficial .htm version (246Kb)
- U.S. Department of Defense (DoD)
needle-free injection policy chronology
- (1997-11-20) Ped-O-Jet®
manufacturer (Keystone Industries, Cherry Hill,
NJ) notifies Defense Supply Center Philadelphia (DSCP)
(Defense Logistics Agency) of intent to withdraw
as device supplier over liability concern for
bloodborne disease transmission from multiple-use-nozzle
design.
- (1997-12-05) DoD Medical Materiel Quality Control Program (MMQCP)
issues withdrawal of automatic jet hypodermic injection
units (MMQC-97-1169).
- (1997-12-07) DSCP issues
Medical Products Quality Control System (MPQCS)
device alert (DSCP 970147) as "cautionary measure",
while noting the absence of bloodborne disease
transmission case reports over 35 years of military
use (followup MMQC-98-1019 dated 1998-Jan-30).
- (1998-01-09) Armed Forces
Epidemiological Board (AFEB) concurs with withdrawal
of Ped-O-Jet® for "routine immunization", but
availability for "public health emergency".
AFEB recommends use of "newer technology" devices
with disposable parts for skin contact.
- (1998-04-20) Navy Bureau of Medicine and Surgery updates
via BUMED notice 6230 its Immunization Requirements
And Recommendations document (3.6Mb .pdf)
prohibiting jet injector use until otherwise directed.
- (1998-04-28) AFEB recommends
DoD formulate new needle-free injector specifications
and support device research and development.
- (1998-07-09) Letter from Dr. Sue Bailey, Assistant
Secretary of Defense, Health Affairs, to United
States Representative Alan B. Mollohan (D-WV),
explaining DoD policy on jet injectors in response
to the concerns of a constituent of the Congressman.
- (1998-1999) Manufacturer
discontinuation of large multi-dose vials
for yellow fever, meningococcal, and tetanus-diphtheria
vaccines because of military withdrawal of Ped-O-Jets®
capable of using them (MMQC-99-1248 dated 1998-Nov-03 and MMQC-99-1251 dated 1999-Aug-12).
- (1998-11-25) Navy Bureau of Medicine and Surgery authorizes
military use of new disposable-cartridge jet injector
(Preventive Medicine Directorate).
- Current DoD policies
and information available at the Military Immunization Information Source
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Conferences |
- 11th
Annual International Conference on Needle-free and
Auto Injectors, London, UK, 27-28 February 2006
(Management Forum, UK)
- 10th
Annual International Conference on Needle-free and
Auto Injectors, London, UK, 28 February - 1 March
2005 (brochure)
(Management Forum, UK)
- 7th Annual Conference on Vaccine
Research, Arlington,
VA, USA, 24-26 May 2004 (program
and abstracts) (National
Foundation for Infectious Diseases)
- Symposium 1 - Needle-free
Vaccination (25 May):
- Trends, challenges,
and opportunities for jet injection technology
- Transcutaneous
immunization: a clinical vaccinology perspective
- Overview of mucosal
immunization
- Pulmonary inhalation
of aerosols or dried powders: the measles
model
- 9th Annual International
Conference on Needle-free and Auto Injectors, London,
UK, 23-24 February 2004 (brochure)
(Management Forum, UK)
- Innovative
Administration Systems for Vaccines, Rockville,
MD, USA, 18-19 December 2003 (Office of the Assistant Secretary for Public
Health Emergency Preparedness, U.S.Department of Health
and Human Services)
- 8th
Annual Conference on Needle-free and Auto Injectors,
London, UK, 24-25 February 2003 (Management Forum, UK)
- Needle-free Injection Systems,
Philadelphia, PA, USA, 3-4 December 2002 (Barnett International)
- 7th Annual Conference on
Needle-free and Auto Injectors, London, UK, 25-26
February 2002 (Management Forum, UK)
- 6th Annual Conference on
Needle-free and Auto Injectors: An Update on Technology
and Application, London, UK, 26-27
February 2001 (Management Forum, UK)
- 5th Annual Conference on
Needle-free and Auto Injectors: An Update on Technology
and Application, London, UK,
28-29 February 2000 (Management Forum, UK)
- Conference on Needle-free Injection
Technology, Bethesda,
MD, USA, 31 March - 1 April 1999
- 1st Annual Conference on Vaccine
Research, Washington,
DC, USA, 30 May - 1 June 1998
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Press coverage |
Needle-free reportage
in medical and lay press
- MAKING MEDICINE EASIER TO SWALLOW,
by Lorilyn Rackl, Daily
Herald (Chicago), 18 November 2002
- THIS WON'T HURT A BIT: Shots Pain
Free, by Dina
Blair, WGN-TV news video, Chicago, IL, 3-4 April 2002
(written
summary)
- Reviving and Old Technology for
Large-scale Vaccination, by Christopher Snowbeck, Pittsburgh Post-Gazette,
20 November 2001
- Eradication Efforts Need Needle-free
Delivery, JAMA,
26 May 1999 (original format .pdf version, pp. 3-5, 173Kb)
- Needle-free Injections Face Obstacles,
Skin & Allergy News 30(8):13, 1999
- Jet Injector Blues: A Market in
Transition,
Rick Mendosa's Diabetes Directory, 10 May 1999
- Ouchless Medicine,
American Medical News, 7 December 1998
- Look Mom, No Pain,
ABC News, 28 September 1998
- Shot in the Dark,
Metro, 6-13 August 1998
- Alternative Vaccination Strategies
Aimed at Decreasing Number of Injections,
Infectious Diseases in Children, June 1998
- The Jet Injector Paradox,
Diabetes Wellness Letter, February 1998
- Taking the 'Ouch" out of Vaccinations,
The Scientist, 19 January 1998.
- No More Pinpricks for the Diabetics,
The Indian Express, 22 December 1997
- Lafene offers needle-free shots
to help prevent winter illnesses, Kansas State Collegian, 6 November 1997
- Needle-free Injections Possible,
Mail & Guardian, 27 May 1997
- Betaseron Administered in a Needle-Free System for
Multiple Sclerosis,
Doctor's Guide, 1 July 1996
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Association of
Needle-free Injection Manufacturers
(ANFIM) |
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Devices |
[Device non-endorsement disclaimer]
- AdvantaJet™,
GentleJet™ (Activa Brand Products)
- Am-O-Jet™
(American Jet Injector, Inc.)
- Antares
MJ 6 (see Medi-Jector Choice™), MJ
7 (see Medi-Jector Vision™, also sold as ZomaJet™
and SciTojet™), MJ
8, MJ 10 (Antares
Pharma)
- Avant
Guardian 101 (Avant Medical Corporation)
- HSI-500™
(Felton
International / PATH)
- Crossject™
(Crossject SA)
- Biojector2000® (Bioject,
Inc.)
- Cool.Click®
(Serono)
(made by Bioject, Inc., see VitaJet)
- DermoJet® & Vacci-Jet
(Société AKRA DERMOJET)
(distributor Robbins
Instruments) (photo)
- Helios™ "gene gun" (Bio-Rad Laboratories,
Inc.)
- Iject™ (Bioject,
Inc., see Biojector 2000®)
- Hyjettor™ (Tokyo Sokuhan
Co., Ltd. [now Nidec
Tosok Corporation], Japan)
- IM-O-JET™
(Institut
Mérieux, Lyon, France [later acquired Pasteur
Vaccins to become Pasteur-Mérieux
Sérums et Vaccins and then Pasteur
Mérieux Connaught; later becoming Aventis
Pasteur which after merger became sanofi-pasteur]; see Mini-Imojet™, below)
- Injex™
(Equidyne Systems, Inc.) (a
supplier)
- IntraJect® (Aradigm
Corporation [device acquired
from Weston
Medical, Ltd.])
- J-Tip® (National Medical Products, Inc.)
- LectraJet™ (patent family members 1,
2,
3,
& 4) (D'Antonio
Consultants International [DCI], Inc.)
- MadaJet™ (MADA
Medical Products, Inc.)
- Med-E-Jet®
(Evans Enterprises)
- Medi-Jector®
Choice™ and Vision™ (see
Antares
Pharma, formerly Medi-Ject Corp.)
- Med-Jet®,
Agro-Jet® (Medical International Technologies
[MIT], Inc.)
- MEDiVAX™
(Program
for Appropriate Technology in Health-PATH)
- Mesoflash® [Isajet™] (Prolitec
SA, formerly Béarn Mécanique Aviation S.A.) (U.S.
patent family members 5049125
and D277506)
- mhi-500™ (InsulinJet™) (The
Medical House, PLC)
- Mini-Imojet™ (Galy1992 *,
Spiegel1994a *,
Fisch1996,
Parent
du Châtelet1997, Schlumberger1999)
[Institut
Mérieux, Lyon, France [later acquired Pasteur
Vaccins to become Pasteur-Mérieux
Sérums et Vaccins and then Pasteur
Mérieux Connaught; later becoming Aventis
Pasteur which after merger became sanofi-pasteur];
see IM-O-JET™, above)
- Mini-Ject™
(Biovalve
Technologies, Inc.)
- Ped-O-Jet®
(Keystone Industries,
Inc.)
- Penjet™
, Penjet™/Micro
(PenJet Corporation)
- PharmaJet™ (PharmaJet, Inc.)
- PMED™
(powder mediated epidermal delivery device)
(PowderMed
Ltd.)
- Pro-Jeey
2000 (Heng Yang Weida Science Technology)
- SeroJet™
(Serono,
Inc.)
- SICIM
JET2000
and DG77 injectors (SICIM Medical
Jet S.p.A.)
- SNAP
JET® (Cambridge
Biostability Ltd.)
- SQ-PEN™,
SQ-X™ (Medical House Products, Ltd.)
- Syrijet™
(Mizzy, Inc., a division of Keystone Industries)
- US patent 5911703 (Avant Drug Delivery Systems, Inc.)
- VACCIJET™
Electrique & VACCIJET™ Manuel (ENDOS Pharma; formerly ENDOSCOPTIC), Laons,
France (US patent D420,739)
- Vitajet® (Bioject, Inc.)
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Injection safety |
Injection safety
organizations, campaigns, and resources relevant to the
needle-free injection market and field
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History |
-
Device
for "Aquapuncture" manufactured
by H. Galante et Compagnie, Paris. Studied clinically
at the thermal
baths of Pierrefonds, France, by Dr.
L. Sales-Girons. Presented at the Imperial
Academy of Medicine, 18 December 1866 by A.
Béclard. Details from pages
43-44 of: Notice
sur quelques nouveaux instruments et appareils de
chirurgie fabriqués par H. Galante,
1866. (See bibliography
for citations to Béclard and Galante.)
- Joannès Servajan, 19th Century
thesis:l'Aquapuncture (Index
file card for 1872 thesis, Faculty of Medicine of
Paris)
- Robert Andrew Hingson
(1913-1996) - Father of the Jet Injector
- Brother's Brother
Foundation biography
- 1967 polio campaign, Costa Rica
(photo)
- Robert Andrew Hingson, 83,
A Pioneer in Public Health.
New York Times obituary, 1996-Oct-12, by
Wolfgang Saxon, Late Edition - Final, Section
1, Page 52, Column 6
- Robert Andrew Hingson, humanitarian.
The Atlanta Journal and The Atlanta Constitution
obituary, 1996-Oct-13, by Kelleigh Scott, Page
G10
-
Medical Giants
exhibit on Robert Hingson, MD, at the American
Society of Anesthesiologists office
in Washington, DC. (Click images for medium size
77 Kb photographs. For large size 1.9 Mb photographs,
click here: left
image and right
image.) (Exhibit prepared by George S. L.
Bause, MD, MPH, Wood
Library - Museum of Anesthesiology, Park Ridge,
Illinois.)
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News service |
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Note: Inquiries, suggestions, comments, and corrections for
this needle-free injection technology page are invited
here. |
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This page last modified on September 12, 2006
Content on this page last reviewed on February
28, 2000 | |
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