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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
June 5, 2008
Volume 20, No. 23

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.


Gene Variant Frequency

Genetic polymorphism analysis of CYP2C19 in Chinese Han populations from different geographic areas of mainland China
Chen L, et al.
Pharmacogenomics 2008 Jun;9(6):691-702

 

Infectious and Parasitic Diseases

HLA class I alleles in HTLV-1-associated myelopathy and asymptomatic carriers from the Brazilian cohort GIPH
Catalan-Soares BC, et al.
Med Microbiol Immunol 2008 Jun

 

Neoplasms

Effect of SLCO1B3 Haplotype on Testosterone Transport and Clinical Outcome in Caucasian Patients with Androgen-Independent Prostatic Cancer
Hamada A, et al.
Clin Cancer Res 2008 Jun;14(11):3312-8

CYP2C19*17 is associated with decreased breast cancer risk
Justenhoven C, et al.
Breast Cancer Res Treat 2008 Jun

Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial
Braun MS, et al.
J Clin Oncol 2008 Jun;26(16):2690-8

Gly82Ser Polymorphism of the Receptor for Advanced Glycation End Products Is Associated with an Increased Risk of Gastric Cancer in a Chinese Population
Gu H, et al.
Clin Cancer Res 2008 Jun;14(11):3627-32

MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9  is not
Langers AM, et al.
Br J Cancer 2008 Jun;98(11):1820-3

Relation of glutathione S-transferase T1, M1 and P1 genotypes and breast cancer risk
Unlu A, et al.
Cell Biochem Funct 2008 Jun

Genetic Polymorphism in EGF Is Associated with Prostate Cancer Aggressiveness and Progression-Free Interval in Androgen Blockade-Treated Patients
Teixeira AL, et al.
Clin Cancer Res 2008 Jun;14(11):3367-71

Genetic variants of miRNA sequences and non-small cell lung cancer survival
Hu Z, et al.
J Clin Invest 2008 Jun

PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations
Nosho K, et al.
Neoplasia 2008 Jun;10(6):534-41

A Novel Functional Polymorphism C1797G in the MDM2 Promoter Is Associated with Risk of Bladder Cancer in a Chinese Population
Wang M, et al.
Clin Cancer Res 2008 Jun;14(11):3633-40

Impact of a Single Nucleotide Polymorphism in the MDM2 Gene on Neuroblastoma Development and Aggressiveness: Results of a Pilot Study on 239 Patients
Cattelani S, et al.
Clin Cancer Res 2008 Jun;14(11):3248-53

 

Endocrine, Nutritional and Metabolic Diseases

Hemochromatosis gene (HFE) mutations in patients with type 2 diabetes and their control group in an Iranian population
Sharifi F, et al.
Saudi Med J 2008 Jun;29(6):808-12

Sequence Analysis of BIRC4/XIAP in Male Patients with Common Variable Immunodeficiency
Salzer U, et al.
Int Arch Allergy Immunol 2008 Jun;147(2):147-51

HLA Class I and Class II Genotyping in Patients with Chronic Urticaria
Coban M, et al.
Int Arch Allergy Immunol 2008 Jun;147(2):135-9

Associations of the apolipoprotein A-I gene polymorphism and serum lipid levels in the Guangxi Hei Yi Zhuang and Han populations
Li Y, et al.
Int J Mol Med 2008 Jun;21(6):753-64

ASSOCIATION BETWEEN micro-OPIOID RECEPTOR-1 102T>C POLYMORPHISM AND INTERMEDIATE  TYPE 2 DIABETES PHENOTYPES: RESULTS FROM THE QUEBEC FAMILY STUDY (QFS)
Ruchat SM, et al.
Clin Exp Pharmacol Physiol 2008 Jun

The synergistic effect of sex hormone-binding globulin and aromatase genes on polycystic ovary syndrome phenotype
Xita N, et al.
Eur J Endocrinol 2008 Jun;158(6):861-5

Type 2 diabetes susceptibility loci in the Ashkenazi Jewish population
Bronstein M, et al.
Hum Genet 2008 May

 

Mental Disorders

Genetic susceptibility to heroin addiction; a candidate-gene association study
Levran O, et al.
Genes Brain Behav 2008 Jun

Variants in Nicotinic Receptors and Risk for Nicotine Dependence
Bierut LJ, et al.
Am J Psychiatry 2008 Jun

Molecular Genetics of Successful Smoking Cessation: Convergent Genome-Wide Association Study Results
Uhl GR, et al.
Arch Gen Psychiatry 2008 Jun;65(6):683-93

The Impact of CYP2D6 and CYP2C19 Polymorphisms on Suicidal Behavior and Substance Abuse Disorder Among Patients With Schizophrenia: A Retrospective Study
Kobylecki CJ, et al.
Ther Drug Monit 2008 Jun;30(3):265-70

Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia
Yevtushenko OO, et al.
Br J Psychiatry 2008 Jun;192:424-8

Association of Tumor Necrosis Factor -308G/A Promoter Polymorphism with Schizophrenia and Bipolar Affective Disorder in a Polish Population
Czerski PM, et al.
Neuropsychobiology 2008 Jun;57(1-2):88-94

Association study between the PIK4CA gene and methamphetamine use disorder in a Japanese population
Kanahara N, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jun

Angiotensin I-converting enzyme I/D polymorphism and suicidal behaviors
Sparks DL, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jun

 

Diseases of the Nervous System and Sense Organs

Sequence Variants in Host Cell Factor C1 Are Associated With Meniere's Disease
Vrabec JT, et al.
Otol Neurotol 2008 Jun;29(4):561-6

Association between mitochondrial DNA 10398A>G polymorphism and the volume of amygdala
Yamasue H, et al.
Genes Brain Behav 2008 Jun

Methyl - CpG - binding protein (MECP2) polymorphisms and vulnerability to autism
Loat C, et al.
Genes Brain Behav 2008 Jun

Additive effect of BDNF and REST polymorphisms is associated with improved general cognitive ability
Miyajima F, et al.
Genes Brain Behav 2008 Jun

Age related macular degeneration is associated with the HLA Cw*0701 genotype and  the Natural Killer cell receptor AA haplotype
Goverdhan SV, et al.
Invest Ophthalmol Vis Sci 2008 May

 

Diseases of the Circulatory System

Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy
Bos JM, et al.
Am Heart J 2008 Jun;155(6):1128-34

Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome
Yamada Y, et al.
Int J Mol Med 2008 Jun;21(6):801-8

Common variation in the CETP gene and the implications for cardiovascular disease and its treatment: an updated analysis
Dullaart RP & Sluiter WJ
Pharmacogenomics 2008 Jun;9(6):747-63

Expression profiling of macrophages from subjects with atherosclerosis to identify novel susceptibility genes
Hagg DA, et al.
Int J Mol Med 2008 Jun;21(6):697-704

 

Diseases of the Respiratory System

A common cortactin gene variation confers differential susceptibility to severe asthma
Ma SF, et al.
Genet Epidemiol 2008 Jun

 

Diseases of the Digestive System

Clinical and molecular characteristics of isolated colonic Crohn's disease
Hancock L, et al.
Inflamm Bowel Dis 2008 Jun

Contributions of IBD5, IL23R, ATG16L1, and NOD2 to Crohn's disease risk in a population-based case-control study: Evidence of gene-gene interactions
Okazaki T, et al.
Inflamm Bowel Dis 2008 Jun

 

Diseases of the Genitourinary System

Association of ABCB1 genetic variants with renal function in Africans and in Caucasians
Bochud M, et al.
BMC Med Genomics 2008 Jun;1(1):21

 

Diseases of the Skin and Subcutaneous Tissue

Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case-control study
Enomoto H, et al.
J Hum Genet 2008 Jun

 

Symptoms, Signs and Ill-defined Conditions

The Role of Cytochrome P2C19 in R-warfarin Pharmacokinetics and its Interaction With Omeprazole
Uno T, et al.
Ther Drug Monit 2008 Jun;30(3):276-81

A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of  cyclosporine
Hesselink DA, et al.
Pharmacogenomics 2008 Jun;9(6):783-9

CYP2D6 Polymorphism in Relation to Tramadol Metabolism: A Study of Faroese Patients
Halling J, et al.
Ther Drug Monit 2008 Jun;30(3):271-5

 

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Page last reviewed: June 5, 2008 (archived document)
Content Source: National Office of Public Health Genomics