Final applications are due June 6, 2008 for CDC's National Office of Public Health Genomics funding opportunity for genomics translation in education, surveillance, and policy interventions.

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer
Malignant Melanoma Classification Given Additional Genetic Component, Medical News Today, June 5	Researchers find gene signature profile for metastasis, News-Medical.Net, June 2
Colon Cancer Survival Has Family Link, CBS News, June 3	Abnormalities found in gene for melanoma, Medical New Today, May 30
Erbitux effective for advanced colorectal cancer patients with normal gene, Medical News Today, June 2	4 your health - Skin and colon cancer, My Fox, May 30

Genetic susceptibility to cancer: the role of polymorphisms in candidate genes Dong LM, et al. JAMA 2008 May;299(20):2423-36

Has enhanced folate status during pregnancy altered natural selection and possibly Autism prevalence? A closer look at a possible link
Rogers EJ
Med Hypotheses 2008 May

Age related mitochondrial degenerative disorders in humans
Reeve AK, et al.
Biotechnol J 2008 Jun

Pharmacogenetics of Immunosuppressants: Progress, Pitfalls and Promises
Cattaneo D, et al.
Am J Transplant 2008 May

Common and rare variants in multifactorial susceptibility to common diseases
Bodmer W & Bonilla C
Nat Genet 2008 Jun;40(6):695-701

Ethical Issues Related To BRCA Gene Testing in Orthodox Jewish Women
Mor P & Oberle K
Nurs Ethics 2008 Jul;15(4):512-22

The impact of inherited thrombophilia on surgery: A factor to consider before transplantation?
Kfoury E, et al.
Mol Biol Rep 2008 May

Pharmacogenetics of bone treatments: the VDR and ERalpha gene story
Massart F, et al.
Pharmacogenomics 2008 Jun;9(6):733-46

Pharmacogenetics of Gilbert's syndrome
Strassburg CP
Pharmacogenomics 2008 Jun;9(6):703-15

Genetic susceptibility to the respiratory effects of air pollution
Yang IA, et al.

Family history of diabetes impacts on interactions between minimal model estimates of insulin sensitivity and glucose effectiveness
Lopez X, et al.
Diabetes Obes Metab 2008 Jun

Family history of suicidal behavior predicts impulsive-aggressive behavior levels in psychiatric outpatients
Diaconu G & Turecki G
J Affect Disord 2008 May

 

BRCA1 germline mutations and tumor characteristics in Chinese women with familial or early-onset breast cancer
Chen W, et al.
Breast Cancer Res Treat 2008 May

Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms
Monsuur AJ, et al.
PLoS ONE 2008;3(5):e2270

Can complement factors 5 and 8 and transthyretin be used as biomarkers for MODY 1 (HNF4A-MODY) and MODY 3 (HNF1A-MODY)?
Karlsson E, et al.
Diabet Med 2008 May

Penetrance estimates for BRCA1 and BRCA2 based on genetic testing in a Clinical Cancer Genetics service setting: risks of breast/ovarian cancer quoted should reflect the cancer burden in the family
Evans DG, et al.
BMC Cancer 2008 May;8(1):155

 

Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study
Lavedan C, et al.
Mol Psychiatry 2008 Jun

Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia
Volpi S, et al.
Mol Psychiatry 2008 Jun

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
Chen WM, et al.
J Clin Invest 2008 Jun

Genome-wide analysis of copy number changes and loss of heterozygosity in myelodysplastic syndrome with del(5q) using high-density single nucleotide polymorphism arrays
Wang L, et al.
Haematologica 2008 May

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending June 4, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Skin and Subcutaneous Tissue
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page