In February 2002, CDC defined 11 measurable performance indicators (noted in Appendix 3) to monitor the progress toward implementing the overarching and four domestic goals and objectives of the 2001 Plan. The indicators were selected based on the appropriateness of the measure for the specific goal or objective of the 2001 Plan, practicality of the measure, and the current and future availability of HIV data. These were the same indicators CDC used for other required reporting including Government Performance and Results Act (GPRA), Office of Management and Budget Program Assessment Rating Tool (PART), and the Healthy People 2010.

To appropriately address the focus on African Americans and MSM in the objectives of the Extended Plan, CDC reviewed the original 11 performance indicators included the 2001 Plan to determine if some indicators needed to be modified or retained or if new ones needed to be added. CDC also added incidence measures for MSM, African Americans, and Hispanics based on a motion from the CHAC on May 8, 2007. Currently, there are 25 performance indicators. Of this number, 17 are new indicators, six are modified, and two were unchanged. Since 2002, CDC has developed new data collection systems and has also included process indicators to measure the impact of prevention interventions. The outputs of these new systems are reflected in the new performance indicators.

Short-term Goal (Indicators 1-5)
Short-term Milestone 1 (Indicators 6-9)
Short-term Milestone 2 (Indicators 10-12)
Short-term Milestone 3 - (Indicators 13-17)