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Sponsored by: |
University of Toronto |
Information provided by: | University of Toronto |
ClinicalTrials.gov Identifier: | NCT00223574 |
A long-term low carbohydrate, high monounsaturated fat diet, compared to a high carbohydrate, low glycemic index diet, results in more rapid progression of diabetes; i.e. increased fasting glucose and glycated hemoglobin, reduced beta-cell function and insulin sensitivity and increased free fatty acids. The deleterious effects of a high carbohydrate diet on plasma lipids are only temporary and do not persist beyond 6 months. A long-term high carbohydrate, low glycemic index diet, compared to a high carbohydrate, high glycemic index diet, improves glycemic control and beta-cell function
Condition | Intervention |
Type 2 Diabetes |
Drug: Control - high carbohydrate, high glycemic index foods Drug: high carbohydrate, low glycemic index foods Drug: low carbohydrate, high monounsaturate fat foods |
MedlinePlus related topics: | Diabetes |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Single Blind, Placebo Control, Parallel Assignment, Efficacy Study |
Official Title: | Long-Term Effect of Altering the Source or Amount of Dietary Carbohydrate in Type 2 Diabetes |
Estimated Enrollment: | 168 |
Study Start Date: | January 2002 |
Estimated Study Completion Date: | October 2004 |
Ages Eligible for Study: | 35 Years to 75 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Canada, Alberta | |||||
Clinical Trials Centre | |||||
Edmonton, Alberta, Canada, T6G 2C8 | |||||
Canada, Ontario | |||||
St. Michael's Hosptial | |||||
Toronto, Ontario, Canada, M5B 1W8 | |||||
St. Joseph's Health Centre | |||||
London, Ontario, Canada, N6G 2M3 | |||||
Canada, Quebec | |||||
Hotel Dieu | |||||
Montreal, Quebec, Canada, H2W 1T8 | |||||
Centre Universitaire de Sante de l'estrie | |||||
Sherbrooke, Quebec, Canada, J1H 5N4 |
University of Toronto |
Principal Investigator: | Thomas MS Wolever, MD, PhD | University of Toronto/St. Michael's Hospital |
Study ID Numbers: | 44205 |
First Received: | September 20, 2005 |
Last Updated: | September 21, 2005 |
ClinicalTrials.gov Identifier: | NCT00223574 |
Health Authority: | Canada: Ethics Review Committee |
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