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Sponsors and Collaborators: |
The University of Texas Health Science Center at San Antonio National Institute on Alcohol Abuse and Alcoholism (NIAAA) |
Information provided by: | The University of Texas Health Science Center at San Antonio |
ClinicalTrials.gov Identifier: | NCT00223444 |
The purpose of the study is to better understand how genetic factors influence individual sensitivity to alcohol.
Condition | Phase |
Alcoholism |
Phase I Phase II |
MedlinePlus related topics: | Alcoholism |
ChemIDplus related topics: | Ethanol |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Clinical-Genetic Variation in GABA/Alcohol Sensitivity |
Specifically, we will determine whether the subject's gene for a brain protein called GABA-alpha-6 is of the "Pro" type or "Ser" type.
Estimated Enrollment: | 40 |
Study Start Date: | August 2002 |
Estimated Study Completion Date: | December 2008 |
Estimated Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
1
Genotype group Pro/Pro
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Genotype group Pro/Ser
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We want to find out if there are specific characteristics of a person's genes which will cause them to respond differently to alcohol. Genes are parts of the chromosomes found in the cells of our bodies which control our physical characteristics such the color of our hair, eyes, and other features. Genes are made up of molecules called "DNA" which carry the genetic information we receive from our parents. Just as genes control our physical characteristics, differences in genetic information may also explain why some people are more sensitive to alcohol or have problems drinking too much.
Ages Eligible for Study: | 21 Years to 25 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Subjects who are English-speaking, children of Hispanic ancestry, 21-25 years of age, who drink alcohol but are not alcohol dependent will be recruited.
Inclusion Criteria:
Exclusion Criteria:
Contact: John D. Roache, Ph.D. | 210-562-5401 | |
Contact: Deanne Hargita, MPA | 210-562-5412 | hargita@uthscsa.edu |
United States, Texas | |||||
UTHSCSA-START Center | Recruiting | ||||
San Antonio, Texas, United States, 78229-3900 | |||||
Contact: Deanne Hargita, MPA 210-562-5412 hargita@uthscsa.edu | |||||
Contact: Sarah Lindauer, MBA 210-562-5402 lindauer@uthscsa.edu | |||||
Sub-Investigator: Joe Harrison, Ph.D. | |||||
Sub-Investigator: John H. Casada, M.D., Ph.D. |
The University of Texas Health Science Center at San Antonio |
National Institute on Alcohol Abuse and Alcoholism (NIAAA) |
Principal Investigator: | John D. Roache, Ph.D. | The University of Texas Health Science Center at San Antonio |
Responsible Party: | The University of Texas Health Science Center at San Antonio ( John D. Roache/Professor ) |
Study ID Numbers: | R21-AA13435-03-A1, AA13435-03A1 |
First Received: | September 13, 2005 |
Last Updated: | July 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00223444 |
Health Authority: | United States: Institutional Review Board |
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