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topotecan hydrochloride![Patient Information Patient Information](https://webarchive.library.unt.edu/eot2008/20081006173649im_/http://www.cancer.gov/images/btn-patient-info.gif) The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20081006173649im_/http://www.cancer.gov/images/spacer.gif) | hycamptamine | | ![](https://webarchive.library.unt.edu/eot2008/20081006173649im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20081006173649im_/http://www.cancer.gov/images/spacer.gif) | Hycamtin | | ![](https://webarchive.library.unt.edu/eot2008/20081006173649im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081006173649im_/http://www.cancer.gov/images/spacer.gif) | TOPO | | ![](https://webarchive.library.unt.edu/eot2008/20081006173649im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20081006173649im_/http://www.cancer.gov/images/spacer.gif) | (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4'; 6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione monohydrochloride | | ![](https://webarchive.library.unt.edu/eot2008/20081006173649im_/http://www.cancer.gov/images/spacer.gif) |
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