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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
January 24, 2008
Volume 20, No. 4

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.


Infectious and Parasitic Diseases

Vitamin D Receptor Gene Haplotypes and Susceptibility to HIV-1 Infection in Injection Drug Users
de la Torre MS, et al.
J Infect Dis 2008 Jan

Interferon regulatory factor-1 polymorphisms are associated with the control of Plasmodium falciparum infection
Mangano VD, et al.
Genes Immun 2008 Jan

Effects of CCR2 and CCR5 Polymorphisms on HIV-1 Infection in Thai Females
Wichukchinda N, et al.
J Acquir Immune Defic Syndr 2008 Jan

 

Neoplasms

Chemokine system polymorphisms, survival and hepatocellular carcinoma occurrence  in patients with hepatitis C virus-related cirrhosis
Nahon P, et al.
World J Gastroenterol 2008 Feb;14(5):713-9

Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent
Garner CP, et al.
Hum Genet 2008 Jan

Distribution of CYP1A12A polymorphism in adult patients with acute lymphoblastic  leukemia in a Mexican population
Gallegos-Arreola MP, et al.
Blood Cells Mol Dis 2008 Jan

Sequence Variants of NAT1 and NAT2 and Other Xenometabolic Genes and Risk of Lung and Aerodigestive Tract Cancers in Central Europe
McKay JD, et al.
Cancer Epidemiol Biomarkers Prev 2008 Jan;17(1):141-7

SnoRNA U50 is a candidate tumor suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer
Dong XY, et al.
Hum Mol Genet 2008 Jan

Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India
Srivastava DS, et al.
Arch Toxicol 2008 Jan

Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study
Beasley WD, et al.
Int J Colorectal Dis 2008 Jan

Influence of cancer-related gene polymorphisms on clinicopathological features in colorectal cancer
Yoshiya G, et al.
J Gastroenterol Hepatol 2008 Jan

Vegetables- and antioxidant-related nutrients, genetic susceptibility, and non-Hodgkin lymphoma risk
Kelemen LE, et al.
Cancer Causes Control 2008 Jan

Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma
Wheatley-Price P, et al.
Cancer 2008 Jan

Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR  C677T Genetic Polymorphism in Esophageal Squamous Cell Carcinoma
Wang J, et al.
Cancer Epidemiol Biomarkers Prev 2008 Jan;17(1):118-25

Polymorphisms in folate metabolizing enzymes and transport proteins and the risk  of breast cancer
Kotsopoulos J, et al.
Breast Cancer Res Treat 2008 Jan

Haplotype Analyses of CYP19A1 Gene Variants and Breast Cancer Risk: Results from  the Shanghai Breast Cancer Study
Cai Q, et al.
Cancer Epidemiol Biomarkers Prev 2008 Jan;17(1):27-32

Dietary vitamin b6 intake and the risk of colorectal cancer
Theodoratou E, et al.
Cancer Epidemiol Biomarkers Prev 2008 Jan;17(1):171-82

Association of TNF-alpha and TNFR1 promoters and 3' UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco-related oral carcinoma in Asian Indians
Gupta R, et al.
Oral Oncol 2008 Jan

 

Endocrine, Nutritional and Metabolic Diseases

Association between liver X receptor alpha gene polymorphisms and risk of metabolic syndrome in French populations
Legry V, et al.
Int J Obes (Lond) 2008 Jan

The association of genetic variants in Kruppel-like factor 11 and Type 2 diabetes in the Japanese population
Tanahashi T, et al.
Diabet Med 2008 Jan;25(1):19-26

Effect of RBP4 gene variants on circulating RBP4 concentration and type 2 diabetes in a Chinese population
Hu C, et al.
Diabet Med 2008 Jan;25(1):11-8

Iron-overload-related disease in HFE hereditary hemochromatosis
Allen KJ, et al.
N Engl J Med 2008 Jan;358(3):221-30

A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study
Hakonarson H, et al.
Diabetes 2008 Jan

 

Mental Disorders

Effect of genetic polymorphisms on smoking cessation: a trial of bupropion in Korean male smokers
Han DH, et al.
Psychiatr Genet 2008 Feb;18(1):11-6

Case-control and within-family tests for an association between conduct disorder  and DAT1
Schulz-Heik RJ, et al.
Psychiatr Genet 2008 Feb;18(1):17-24

Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder
Amano K, et al.
Psychiatr Genet 2008 Feb;18(1):1-10

Further support for association of the mitochondrial complex I subunit gene NDUFV2 with bipolar disorder
Xu C, et al.
Bipolar Disord 2008 Feb;10(1):105-10

Interaction of dopamine transporter genotype with prenatal smoke exposure on ADHD symptoms
Becker K, et al.
J Pediatr 2008 Feb;152(2):263-9

No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics
Sanders AR, et al.
Am J Psychiatry 2008 Jan

A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder
Liu Z, et al.
J Psychiatry Neurosci 2008 Jan;33(1):43-6

Personality in relation to genetic liability for schizophrenia and bipolar disorder: Differential associations with the COMT Val(108/158)Met polymorphism
Silberschmidt AL & Sponheim SR
Schizophr Res 2008 Jan

Genetic association study of BDNF in depression: Finding from two cohort studies  and a meta-analysis
Chen L, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jan

 

Diseases of the Nervous System and Sense Organs

DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association study
Schwab SG, et al.
Psychiatr Genet 2008 Feb;18(1):25-30

Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration
Chen H, et al.
Vision Res 2008 Jan

Apolipoprotein E epsilon4, Alzheimer's Disease, and Cognitive Performance in Elderly Mexican Mestizos
Villalpando-Berumen JM, et al.
J Am Geriatr Soc 2008 Jan

Gene-environment interaction in progression of AMD - the CFH gene, smoking and exposure to chronic infection
Baird PN, et al.
Hum Mol Genet 2008 Jan

Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with  age-related macular degeneration
Gibbs D, et al.
Vision Res 2008 Jan

Gene-Gene Interaction Between FGF20 and MAOB in Parkinson Disease
Gao X, et al.
Ann Hum Genet 2008 Jan

The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer's disease in Chinese
Wang B, et al.
J Neurol Sci 2008 Jan

Genes Controlling Affiliative Behavior as Candidate Genes for Autism
Yrigollen CM, et al.
Biol Psychiatry 2008 Jan

 

Diseases of the Circulatory System

Fibrinogen Genes and Myocardial Infarction. A Haplotype Analysis
Koch W, et al.
Arterioscler Thromb Vasc Biol 2008 Jan

Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Tunisian patients with severe coronary artery disease
Ghazouani L, et al.
J Thromb Thrombolysis 2008 Jan

Genetic variation in heme oxygenase 1 (HMOX1) and the risk of recurrent venous thromboembolism
Mustafa S, et al.
J Vasc Surg 2008 Jan

Estrogen Receptor-alpha Genotype Affects Exercise-Related Reduction of Arterial Stiffness
Hayashi K, et al.
Med Sci Sports Exerc 2008 Jan

Polymorphisms of angiotensin-converting enzyme 2 gene associated with magnitude of left ventricular hypertrophy in male patients with hypertrophic cardiomyopathy
Wang SX, et al.
Chin Med J (Engl) 2008 Jan;121(1):27-31

Effect of ACE inhibitors and beta-blockers on homocysteine levels in essential hypertension
Poduri A, et al.
J Hum Hypertens 2008 Jan

Thrombomodulin gene polymorphisms in brain infarction and mortality after stroke
Olivot JM, et al.
J Neurol 2008 Jan

 

Diseases of the Respiratory System

FcgammaRIIIa-V/F 158 polymorphism in Turkish children with asthma bronchiale and  allergic rhinitis
Zeyrek D, et al.
Pediatr Allergy Immunol 2008 Feb;19(1):20-4

A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma
Bai C, et al.
Int J Mol Med 2008 Feb;21(2):139-44

Association of interleukin-18 gene polymorphism with asthma in Chinese patients
Lee CC, et al.
J Clin Lab Anal 2008 Jan;22(1):39-44

Uteroglobin-related protein 1 gene -112G/A polymorphism and atopic asthma in Sicilian children
Rigoli L, et al.
Allergy Asthma Proc 2007 Nov-2007 Dec;28(6):667-70

 

Diseases of the Digestive System

Tooth loss after active periodontal therapy. 1: patient-related factors for risk, prognosis, and quality of outcome
Eickholz P, et al.
J Clin Periodontol 2008 Feb;35(2):165-74

CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population
Baptista ML, et al.
Inflamm Bowel Dis 2008 Jan

Association of vitamin D receptor gene polymorphisms in Chinese patients with generalized aggressive periodontitis
Li S, et al.
J Periodontal Res 2008 Jan

Evaluation of the MLH1 I219V alteration in DNA mismatch repair activity and ulcerative colitis
Plotz G, et al.
Inflamm Bowel Dis 2008 Jan

Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease
Beckly JB, et al.
Inflamm Bowel Dis 2008 Jan

 

Diseases of the Genitourinary System

ACE Gene Polymorphism and Losartan Treatment in Type 2 Diabetic Patients With Nephropathy
Parving HH, et al.
J Am Soc Nephrol 2008 Jan

 

Complications of Pregnancy, Childbirth, and the Puerperium

G/A Polymorphism at -258 of the Hepatic Glucokinase Promoter Is Not Associated with Decreased Birth Weight in Preterm Neonates
Pawlowski M, et al.
Neonatology 2008 Jan;94(2):71-4

 

Diseases of the Skin and Subcutaneous Tissue

Specific Filaggrin Mutations Cause Ichthyosis Vulgaris and Are Significantly Associated with Atopic Dermatitis in Japan
Nomura T, et al.
J Invest Dermatol 2008 Jan

IFN-Regulatory Factor 5 Gene Variants Interact with the Class I MHC Locus in the  Swedish Psoriasis Population
Sanchez FO, et al.
J Invest Dermatol 2008 Jan

PTPN22 Is Genetically Associated with Risk of Generalized Vitiligo, but CTLA4 Is  Not
Laberge GS, et al.
J Invest Dermatol 2008 Jan

 

Diseases of the Musculoskeletal System and Connective Tissue

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
Nath SK, et al.
Nat Genet 2008 Jan

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
Kozyrev SV, et al.
Nat Genet 2008 Jan

The MMP2 rs243865-T allele is not a major genetic factor for rheumatoid arthritis in the French Caucasian population
Jacq L, et al.
Int J Immunogenet 2008 Jan

Polymorphisms in COL15 Gene Are Not Associated with Systemic Sclerosis
Pushpakom SP, et al.
J Rheumatol 2008 Jan

The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis
Rueda B, et al.
Ann Rheum Dis 2008 Jan

A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus
Nath SK, et al.
Nat Genet 2008 Jan

 

Congenital Anomalies

Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts
Boyles AL, et al.
Am J Med Genet A 2008 Jan

 

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Page last reviewed: January 24, 2008 (archived document)
Content Source: National Office of Public Health Genomics