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 Thursday, January 24, 2008 Volume 20   Number 4
Update banner Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on disease prevention & public health. open mailbox for email deliveryGet email updates
Spotlight
breast cancer ribbon New Genomics Evidence Report
A CDC-sponsored evidence report on the Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes has been released by the Agency for Healthcare Research and
Quality. Learn more about EGAPP's role in the report non-gov warning icon
Sections

 > View Current Update
blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
blue dotBack Issues

 Upcoming Events

49th Annual Short Course on Medical and Experimental Mammalian Genetics  non-gov warning icon

American College of Medical Genetics Annual Meeting non-gov warning icon

Integrative Cancer
Genomics
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 Let's Go Surfing

1000 Genomes non-gov warning icon

Public Health Genomics European Network non-gov warning icon

'Ask the Expert' at the World Health Organization's Genomic Research Center non-gov warning icon


Genomics Announcements
 
CDC sponsored material
CDC's National Office of Public Health Genomics is looking for a new geneticist. For more information about the position, click on the U.S. Department of Health and Human Services website and enter the vacancy number (HHS-CDC-T2-2008-0158 – for current employees or HHS-CDC-D2-2008-0091 – for non-federal applicants). The deadline to apply is February 1, 2008.
   
bullhorn

The National Institutes of Health (NIH) to host a meeting on "Translating Whole Genome Association Data into Clinical Research and Practice", March 10-11, 2008 in Bethesda, MD, as part the NIH Genes, Environment, and Health Initiative

 
CDC sponsored material
CDC's National Office of Public Health Genomics announces a new funding opportunity for those interested in genomics translation research.
Important deadlines - Letter of intent: January 28, 2008; Final application: February 27, 2008. Have questions? Email us at genetics@cdc.gov.
   
CDC sponsored material
HuGENet™ What's New
January 2008


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Birth Defects

NIH develops Down Syndrome research plannon-gov warning icon NIH News, January 22


Cancer

Simple genetic test for prostate cancer may soon be available, non-gov warning icon Medical News Today, January 18

Prostate cancer risk nine times higher for men with five gene markers and family history, non-gov warning icon Medical News Today, January 17

New function for colon cancer gene found, non-gov warning icon EurekAlert, January 17

 

Cardiovascular Disease

Gene variations associated with effectiveness of blood pressure medications, non-gov warning icon News-Medical.Net, January 23

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Ethical, Legal and Social Issues (ELSI)
Debate over safety of gene therapy trials focuses on issue of informed consent, non-gov warning icon News-Medical.Net, January 23 Growth of genetic tests concerns federal panel, non-gov warning icon New York Times, January 18
New handbook promotes good practices for use of genetic resources, non-gov warning icon Yahoo, January 22

 

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Genetic Testing

Breast cancer gene testing less likely among blacks, non-gov warning icon Reuters Health, January 17

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Mental Health

Genetic test to predict antidepressant response, non-gov warning icon Medical News Today, January 24

Canadian-led scientists find more genetic flaws linked to autism, non-gov warning icon Yahoo News, January 17

Evidence found for genes that affect risk of developing Alzheimer's disease, non-gov warning icon Science Daily, January 21

 

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Other News

Skin care: Scar-free healing shown with gene suppression, non-gov warning icon Science Daily, January 24 

Smoking wipes out protective genes, non-gov warning icon News-Medical.Net, January 21

Detailed gene map 'within grasp', non-gov warning icon BBC News, January 22

Discovery opens door to 'personalized' asthma therapy, non-gov warning icon News-Medical.Net, January 20

Genetic link to lupus, NHS response, non-gov warning icon Medical News Today, January 22

Discovery of new genetic mutation that halts the development of lupus, non-gov warning icon Medical News Today, January 18

NIH announces new initiative in epigenomics, non-gov warning icon NIH News, January 22

Genetic diversity of European Americans and disease gene mapping, non-gov warning icon Medical News Today, January 18

International consortium announces the 1000 genomes project, non-gov warning icon NIH News, January 22

Genetic testing named as official journal of genetic alliance, non-gov warning icon Medical News Today, January 18

New knowledge base of gene-disease
relationships
, non-gov warning icon News-Medical.Net, January 22

Genetic differences may help explain response to multiple sclerosis treatment, non-gov warning icon Science Daily, January 17

Scientists identify genes linked to lupus in
women
, non-gov warning icon Medical News Today, January 22

Rare and undetected genetic disease killed Winona State student at age 22, non-gov warning icon Star Tribune, January 17

Minute genetic differences have major consequences, non-gov warning icon News-Medical.Net, January 21

 
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Genomics in Scientific Literature
Featured Item

Cumulative Association of Five Genetic Variants with Prostate Cancer
Zheng SL, et al.
N Engl J Med 2008 Jan

 General Articles

Genetics of therapy-related myelodysplasia and acute myeloid leukemia
Pedersen-Bjergaard J, et al.
Leukemia 2008 Jan

Recent advances in asthma genetics
Zhang J, et al.
Respir Res 2008 Jan;9(1):4

The thrifty epigenotype: An acquired and heritable predisposition for obesity and diabetes?
Stoger R
Bioessays 2008 Jan;30(2):156-66

The use by Alabama pediatricians of genetics consultation in the evaluation of developmental delay
Chen MJ, et al.
Am J Med Genet A 2008 Jan

Genome-wide significance for dense SNP and resequencing data
Hoggart CJ, et al.
Genet Epidemiol 2008 Jan;32(2):179-85

Epistasis in sporadic Alzheimer's disease
Combarros O, et al.
Neurobiol Aging 2008 Jan

PGMapper: a web-based tool linking phenotype to genes
Xiong Q, et al.
Bioinformatics 2008 Jan

Genetic Susceptibility to Atopic Dermatitis
Kiyohara C, et al.
Allergol Int 2008 Mar;57(1):39-56

An ensemble learning approach jointly modeling main and interaction effects in genetic association studies
Zhang Z, et al.
Genet Epidemiol 2008 Jan

Singleton SNPs in the human genome and implications for genome-wide association studies
Ke X, et al.
Eur J Hum Genet 2008 Jan

Design and Validation of Methods Searching for Risk Factors in Genotype Case-Control Studies
Brinza D & Zelikovsky A
J Comput Biol 2008 Jan

The public's attitudes towards the use of genetic information for medical purposes and its related factors in Japan
Ikeda W
Community Genet 2008;11(1):18-25

The role of genes in growth and later health
Eriksson JG
Nestle Nutr Workshop Ser Pediatr Program 2008;61:69-77

 

 Genetic Testing

Genetic testing and tumor surveillance for children with cancer predisposition syndromes
Rao A, et al.
Curr Opin Pediatr 2008 Feb;20(1):1-7

A systematic review of perceived risks, psychological and behavioral impacts of genetic testing
Heshka JT, et al.
Genet Med 2008 Jan;10(1):19-32

Living with genetic risk: Effect on adolescent self-concept
McConkie-Rosell A, et al.
Am J Med Genet C Semin Med Genet 2008 Jan

Attitudes regarding predictive genetic testing in minors: A survey of European clinical geneticists
Borry P, et al.
Am J Med Genet C Semin Med Genet 2008 Jan

Should genetic testing for BRCA1/2 be permitted for minors? Opinions of BRCA mutation carriers and their adult offspring
Bradbury AR, et al.
Am J Med Genet C Semin Med Genet 2008 Jan

 

 Family History

Maternal reports of family history from the National Birth Defects Prevention Study, 1997-2001
Green RF, et al.
Genet Med 2008 Jan;10(1):37-45

Accuracy of self-reported family history of cancer in a large case-control study  of ovarian cancer
Soegaard M, et al.
Cancer Causes Control 2008 Jan

Beliefs about cancer causation and prevention as a function of personal and family history of cancer: a national, population-based study
Lykins EL, et al.
Psychooncology 2008 Jan

Association of CDH1 single nucleotide polymorphisms with susceptibility to esophageal squamous cell carcinomas and gastric cardia carcinomas
Zhang XF, et al.
Dis Esophagus 2008;21(1):21-9

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending January 23, 2008, there are HuGE articles in the following areas:

Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies

For more information on HuGE, please visit the HuGENet™ home page

 

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Page last updated: January 24, 2008 (archived document)
Content Source: National Office of Public Health Genomics