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Our Science – Nicklaus Website

Marc C. Nicklaus, Ph.D.

Selected Publications
1)  Barchi JJ, Karki RG, Nicklaus MC, Siddiqui MA, George C, Mikhailopulo IA, Marquez VE.
Comprehensive Structural Studies of 2',3'-Difluorinated Nucleosides: Comparison of Theory, Solution, and Solid State.
J. Am. Chem. Soc. 2008. [Journal]
2)  Sitzmann M, Filippov IV, Nicklaus MC.
Internet resources integrating many small-molecule databases(1).
SAR and QSAR in environmental research. 19: 1-9, 2008. [Journal]
3)  Liao C, Karki RG, Marchand C, Pommier Y, Nicklaus MC.
Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA.
Bioorg Med Chem Lett. 2007. [Journal]
4)  Comin MJ, Agbaria R, Ben-Kasus T, Huleihel M, Liao C, Sun G, Nicklaus MC, Deschamps JR, Parrish DA, Marquez VE.
Sculpting the Bicyclo[3.1.0]hexane Template of Carbocyclic Nucleosides to Improve Recognition by Herpes Thymidine Kinase.
J Am Chem Soc. 129: 6216-6222, 2007. [Journal]
5)  Kang SU, Choi WJ, Oishi S, Lee K, Karki RG, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR.
Examination of acylated 4-aminopiperidine-4-carboxylic acid residues in the phosphotyrosyl+1 position of Grb2 SH2 domain-binding tripeptides.
J. Med. Chem. 50: 1978-82, 2007. [Journal]
6)  Filippov I, Sitzmann M, Ihlenfeldt W, Nicklaus M.
Chemicals and Chemoinformatics Tools and User Services.
CADD Group Web Server. 0, 2006. Full Text Article. [Journal]
7)  Jiang S, Li P, Peach ML, Bindu L, Worthy KW, Fisher RJ, Burke TR, Nicklaus M, Roller PP.
Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.
Biochem. Biophys. Res. Commun. 349: 497-503, 2006. [Journal]
8)  Zhao XZ, Semenova EA, Liao C, Nicklaus M, Pommier Y, Burke TR.
Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands.
Bioorg. Med. Chem. 14: 7816-25, 2006. [Journal]
9)  Choi WJ, Shi ZD, Worthy KM, Bindu L, Karki RG, Nicklaus MC, Fisher RJ, Burke TR.
Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles.
Bioorg. Med. Chem. Lett. 16: 5265-9, 2006. [Journal]
10)  Shi ZD, Karki RG, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR.
Utilization of a common pathway for the synthesis of high affinity macrocyclic Grb2 SH2 domain-binding peptide mimetics that differ in the configuration at one ring junction.
Chem. Biodivers. 2: 447-56, 2005. [Journal]
11)  Burke TR, Kang S, Choi W, Shi Z, Karki RG, Phan J, Worthy KM, Bindu L, Nicklaus MC, Waugh D, Fisher RJ.
Application of phenylphosphate mimetics to the design and synthesis of olefin metathesisderived Grb2 SH2 domain-binding macrocycles.
Biopolymers. 80: 536, 2005. [Journal]
12)  Liu F, Oishi S, Karki RG, Shi Z, Worthy KM, Bindu L, Maderia M, Nicklaus MC, Barchi JJ, Fisher RJ, Burke TR.
High affinity Grb2 SH2 domain-binding macrocycles derived from ring-closing metathesis of alkenylglycine residues with beta-vinyl phosphotyrosyl mimetics.
Biopolymers. 80: 574, 2005. [Journal]
13)  Liu F, Oishi S, Karki R, Shi Z, Worthy KM, Bindu LK, Maderia M, Nicklaus M, Barchi Jr JJ, Fisher RJ, Burke Jr TR. Blondelle SE, eds.
High affinity Grb2 SH2 domain-binding macrocycles derived from ring-closing methathesis of alkenylglycine residues with beta-vinyl phosphotyrosyl mimetics. In: Understanding Biology Using Peptides. Volume .
La Costa, CA: American Peptide Society; 2005. p. 559-560 [Book Chapter]
14)  Kang S, Shi Z, Karki R, Phan J, Worthy KM, Bindu LK, Nicklaus M, Waugh DS, Fisher RJ, Burke Jr TR. Blondelle SE, eds.
Application of phenylphosphate mimetics to the design and synthesis of olefin metathesis-derived Grb2 SH2 domain-binding macrocycles. In: Understanding Biology Using Peptides. Volume .
La Costa, CA: American Peptide Society; 2005. p. 180-181 [Book Chapter]
15)  Sun G, Nicklaus MC, Xie RH.
Structure, stability, and NMR properties of lower fullerenes C38-C50 and azafullerene C44N6.
The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. 109: 4617-22, 2005. [Journal]
16)  Richard AM, Gold LS, Nicklaus MC.
Chemical structure indexing of toxicity data on the internet: Moving toward a flat world.
Cur Opin Drug Discov & Develop. 9: 314-325, 2006. Full Text Article. [Journal]
17)  Baleja JD, Cherry JJ, Liu Z, Gao H, Nicklaus MC, Voigt JH, Chen JJ, Androphy EJ.
Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins.
Antiviral Res. 72: 49-59, 2006. [Journal]
18)  Sun G, Voigt JH, Marquez VE, Nicklaus MC.
PROSIT, an online service to calculate pseudorotational parameters of nucleosides and nucleotides.
Nucleosides Nucleotides Nucleic Acids. 24: 1029-32, 2005. [Journal]
19)  Simmons DP, Peach ML, Friedman JR, Green MM, Nicklaus MC, De Luca LM.
Evidence that sequence homologous region in LRAT-like proteins possesses anti-proliferative activity and DNA binding properties: translational implications and mechanism of action.
Carcinogenesis. 27: 693-707, 2005. [Journal]
20)  Kang JH, Peach ML, Pu Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.
J Med Chem. 48: 5738-48, 2005. [Journal]
21)  Oishi S, Karki RG, Shi ZD, Worthy KM, Bindu L, Chertov O, Esposito D, Frank P, Gillette WK, Maderia M, Hartley J, Nicklaus MC, Barchi JJ, Fisher RJ, Burke TR.
Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic.
Bioorg Med Chem. 13: 2431-8, 2005. [Journal]
22)  Karki RG, Tang Y, Burke TR, Nicklaus MC.
Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design.
J Comput Aided Mol Des. 18: 739-60 [Vol. year: 2004], 2005. [Journal]
23)  Oishi S, Kang UK, Karki RG, Worthy KM, Bindu L, Chertov O, Esposito D, Frank P, Gillette WK, Nicklaus MC, Hartley J, Fisher RJ, Burke Jr TR. Shimohigashi Y, eds.
Synthesis and application of novel phosphotyrosyl mimetics to Grb2 SH2 domain-binding inhibitors. In: Peptide Science 2004. Volume .
Osaka: The Japanese Peptide Society; 2005. p. 397-400 [Book Chapter]
24)  Oishi S, Shi ZD, Karki RG, Worthy KM, Bindu L, Chertov O, Esposito D, Frank P, Gillette WK, Maderia M, Barchi Jr JJ, Nicklaus MC, Hartley J, Fisher RJ, Burke Jr TR. Shimohigashi Y, eds.
Application of beta-branched allylglycine equivalents to macrocyclic Grb2 SH2 domain-binding inhibitors. In: Peptide Science 2004. Volume .
Osaka: The Japanese Peptide Society; 2005. p. 123-126 [Book Chapter]
25)  Shi ZD, Karki RG, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR.
Utilization of a Common Pathway for the Synthesis of High Affinity Macrocyclic Grb2 SH2 Domain-Binding Peptide Mimetics That Differ in the Configuration at One Ring Junction.
Chem Biodivers. 2: 447-456, 2005. [Journal]
26)  Shi ZD, Karki RG, Oishi S, Worthy KM, Bindu LK, Dharmawardana PG, Nicklaus MC, Bottaro DP, Fisher RJ, Burke TR.
Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic.
Bioorg Med Chem Lett. 15: 1385-8, 2005. [Journal]
27)  Oishi S, Karki RG, Kang SU, Wang X, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR.
Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.
J Med Chem. 48: 764-72, 2005. [Journal]
28)  Lung FT, Chang C, Chong M, Liou C, Li P, Peach ML, Nicklaus MC, Lou B, Roller PP.
Small nonphosphorylated Grb2-SH2 domain antagonists evaluated by surface plasmon resonance technology.
Biopolymers. 80: 628-635, 2005. [Journal]
29)  Williams KL, Zhang Y, Shkriabai N, Karki RG, Nicklaus MC, Kotrikadze N, Hess S, Le Grice SF, Craigie R, Pathak VK, Kvaratskhelia M.
Mass Spectrometric Analysis of the HIV-1 Integrase-Pyridoxal 5'-Phosphate Complex Reveals a New Binding Site for a Nucleotide Inhibitor.
J Biol Chem. 280: 7949-55, 2005. [Journal]
30)  Sun G, Voigt JH, Filippov IV, Marquez VE, Nicklaus MC.
PROSIT: Pseudo-Rotational Online Service and Interactive Tool, Applied to a Conformational Survey of Nucleosides and Nucleotides.
J Chem Inf Comput Sci. 44: 1752-62, 2004. [Journal]
31)  Tamamura H, Sigano DM, Lewin NE, Peach ML, Nicklaus MC, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C).
J Med Chem. 47: 4858-64, 2004. [Journal]
32)  Xie RH, Bryant GW, Sun G, Nicklaus MC, Heringer D, Frauenheim T, Manaa MR, Smith VH, Araki Y, Ito O.
Excitations, optical absorption spectra, and optical excitonic gaps of heterofullerenes. I. C(60), C(59)N(+), and C(48)N(12): Theory and experiment.
J Chem Phys. 120: 5133-47, 2004. [Journal]
33)  Marquez VE, Ben-Kasus T, Barchi JJ, Green KM, Nicklaus MC, Agbaria R.
Experimental and structural evidence that herpes 1 kinase and cellular DNA polymerase(s) discriminate on the basis of sugar pucker.
J Am Chem Soc. 126: 543-9, 2004. [Journal]
34)  Choi Y, Sun G, George C, Nicklaus MC, Kelley JA, Marquez VE.
Synthesis and conformational analysis of a locked analogue of carbovir built on a bicyclo[3.1.0]hex-2-enyl template.
Nucleosides Nucleotides Nucleic Acids. 22: 2077-91, 2003. [Journal]
35)  Liu DG, Gao Y, Voigt JH, Lee K, Nicklaus MC, Wu L, Zhang ZY, Burke TR.
Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.
Bioorg Med Chem Lett. 13: 3005-7, 2003. [Journal]
36)  Marchand C, Johnson AA, Karki RG, Pais GC, Zhang X, Cowansage K, Patel TA, Nicklaus MC, Burke TR, Pommier Y.
Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S).
Mol Pharmacol. 64: 600-9, 2003. [Journal]
37)  Sigano DM, Peach ML, Nacro K, Choi Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE.
Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).
J Med Chem. 46: 1571-9, 2003. [Journal]
38)  Zhang X, Pais GC, Svarovskaia ES, Marchand C, Johnson AA, Karki RG, Nicklaus MC, Pathak VK, Pommier Y, Burke TR.
Azido-Containing aryl beta-Diketo acid HIV-1 integrase inhibitors.
Bioorg Med Chem Lett. 13: 1215-9, 2003. [Journal]
39)  Poroikov VV, Filimonov DA, Ihlenfeldt WD, Gloriozova TA, Lagunin AA, Borodina YV, Stepanchikova AV, Nicklaus MC.
PASS biological activity spectrum predictions in the enhanced open NCI database browser.
J Chem Inf Comput Sci. 43: 228-36, 2003. [Journal]
40)  Neamati N, Lin Z, Karki RG, Orr A, Cowansage K, Strumberg D, Pais GC, Voigt JH, Nicklaus MC, Winslow HE, Zhao H, Turpin JA, Yi J, Skalka AM, Burke TR, Pommier Y.
Metal-dependent inhibition of HIV-1 integrase.
J Med Chem. 45: 5661-70, 2002. [Journal]
41)  Strumberg D, Nitiss JL, Dong J, Walker J, Nicklaus MC, Kohn KW, Heddle JG, Maxwell A, Seeber S, Pommier Y.
Importance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action.
Antimicrob Agents Chemother. 46: 2735-46, 2002. [Journal]
42)  Ihlenfeldt WD, Voigt JH, Bienfait B, Oellien F, Nicklaus MC.
Enhanced CACTVS browser of the Open NCI Database.
J Chem Inf Comput Sci. 42: 46-57, 2002. [Journal]
43)  Lee J, Han KC, Kang JH, Pearce LL, Lewin NE, Yan S, Benzaria S, Nicklaus MC, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity.
J Med Chem. 44: 4309-12, 2001. [Journal]
44)  Marquez VE, Wang P, Nicklaus MC, Maier M, Manoharan M, Christman JK, Banavali NK, Mackerell AD.
Inhibition of (cytosine C5)-methyltransferase by oligonucleotides containing flexible (cyclopentane) and conformationally constrained (bicyclo[3.1.0]hexane) abasic sites.
Nucleosides Nucleotides Nucleic Acids. 20: 451-9, 2001. [Journal]
45)  Nacro K, Sigano DM, Yan S, Nicklaus MC, Pearce LL, Lewin NE, Garfield SH, Blumberg PM, Marquez VE.
An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P).
J Med Chem. 44: 1892-904, 2001. [Journal]
46)  Voigt JH, Bienfait B, Wang S, Nicklaus MC.
Comparison of the NCI open database with seven large chemical structural databases.
J Chem Inf Comput Sci. 41: 702-12, 2001. [Journal]
47)  Wang PY, Brank AS, Banavali NK, Nicklaus MC, Marquez VE, Christman JK, MacKerell AD.
Use of Oligodeoxyribonucleotides with Conformationally Constrained Abasic Sugar Targets to Probe the Mechanism of Base Flipping by HhaI DNA (Cytosine C5)-methyltransferase.
J Am Chem Soc. 122: 12422-12434, 2000. [Journal]
48)  Chen IJ, Neamati N, Nicklaus MC, Orr A, Anderson L, Barchi JJ, Kelley JA, Pommier Y, MacKerell AD.
Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets.
Bioorg Med Chem. 8: 2385-98, 2000. [Journal]
49)  Mu L, Sarafianos SG, Nicklaus MC, Russ P, Siddiqui MA, Ford H, Mitsuya H, Le R, Kodama E, Meier C, Knispel T, Anderson L, Barchi JJ, Marquez VE.
Interactions of conformationally biased north and south 2'-fluoro-2', 3'-dideoxynucleoside 5'-triphosphates with the active site of HIV-1 reverse transcriptase.
Biochemistry. 39: 11205-15, 2000. [Journal]
50)  Ford H, Dai F, Mu L, Siddiqui MA, Nicklaus MC, Anderson L, Marquez VE, Barchi JJ.
Adenosine deaminase prefers a distinct sugar ring conformation for binding and catalysis: kinetic and structural studies.
Biochemistry. 39: 2581-92, 2000. [Journal]
51)  Marquez VE, Russ P, Alonso R, Siddiqui MA, Hernandez S, George C, Nicklau MC, Dai F, Ford H.
Synthesis of Conformationally Restricted Carbocyclic Nucleosides: The Role of the O(4')-Atom in the Key Hydration Step of Adenosine Deaminase.
Helvetica Chimica Acta. 82: 2119-2129, 1999. [Journal]
52)  Dirk S, Nitiss JL, Dong JW, Nicklaus MC, Kohn KW, Heddle JG, Maxwell A, Pommier Y.
The Third Alpha-helix of the CAP Homology Domain of Type H Topoisomerases is Critical for DNA Cleavage Site Recognition and Quinolone-action.
Clinical Cancer Research. 5: 670-, 1999. [Journal]
53)  Marquez VE, Russ P, Alonso R, Siddiqui MA, Shin KJ, George C, Nicklaus MC, Dai F, Ford H.
Conformationally restricted nucleosides. The reaction of adenosine deaminase with substrates built on a bicyclo[3.1.0]hexane template.
Nucleosides Nucleotides. 18: 521-30, 1999. [Journal]
54)  Strumberg D, Nitiss JL, Rose A, Nicklaus MC, Pommier Y.
Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions.
J Biol Chem. 274: 7292-301, 1999. [Journal]
55)  Nicklaus MC, Williams RW, Bienfait B, Billings ES, Hodoscek M.
Computational chemistry on commodity-type computers.
J Chem Inf Comput Sci. 38: 893-905, 1998. [Journal]
56)  Milne GW, Nicklaus MC, Wang S.
Pharmacophores in drug design and discovery.
SAR QSAR Environ Res. 9: 23-38, 1998. [Journal]
57)  Nicklaus MC.
Conformational Energies Calculated by the Molecular Mechanics Progam CHARMm.
J Comput Chem. 18: 1997, 1056-1060. [Journal]
58)  Neamati N, Hong H, Mazumder A, Wang S, Sunder S, Nicklaus MC, Milne GW, Proksa B, Pommier Y.
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
J Med Chem. 40: 942-51, 1997. [Journal]
59)  Hong H, Neamati N, Wang S, Nicklaus MC, Mazumder A, Zhao H, Burke TR, Pommier Y, Milne GW.
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.
J Med Chem. 40: 930-6, 1997. [Journal]
60)  Nicklaus MC, Neamati N, Hong H, Mazumder A, Sunder S, Chen J, Milne GW, Pommier Y.
HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.
J Med Chem. 40: 920-9, 1997. [Journal]
61)  Milne GW, Wang S, Nicklaus MC.
Molecular modeling in the discovery of drug leads.
J Chem Inf Comput Sci. 36: 726-30, 1996. [Journal]
62)  Wang S, Milne GW, Yan X, Posey IJ, Nicklaus MC, Graham L, Rice WG.
Discovery of novel, non-peptide HIV-1 protease inhibitors by pharmacophore searching.
J Med Chem. 39: 2047-54, 1996. [Journal]
63)  Nicklaus MC, Ford H, Hegedus L, Milne WA, Kelley JA.
Comparative molecular field analysis of hydrophobicity descriptors of cytosine nucleosides.
Quant Struct-Act Rel. 14: 335-343, 1995. [Journal]
64)  Marquez VE, Jeong LS, Nicklaus MC, George C.
Synthesis and Biological-Activity of Sugar-Fluorinated 2',2'-Dideoxy-4'-thioribofuranosyl Nucleosides.
Nucleosides & Nucleotides. 14: 555-558, 1995. [Journal]
65)  Nicklaus MC, Wang S, Driscoll JS, Milne GW.
Conformational changes of small molecules binding to proteins.
Bioorg Med Chem. 3: 411-28, 1995. [Journal]
66)  Jeong LS, Nicklaus MC, George C, Marquez VE.
Down Hydroxyl Groups - Retention of Configuration after Fluoride Opening of the Quaternized N-3-MEM Anhydronucleotides.
Tet Lett. 35: 7573-7576, 1994. [Journal]
67)  Jeong LS, Nicklaus MC, George C, Marquez VE.
Unanticipated Retention of Configuration in the Dast Fluorination of Deoxy-4'-Thiopyrimidine Nucleosides with Up Hydroxyl Groups.
Tet Lett. 35: 7569-7572, 1994. [Journal]
68)  Rodriguez JB, Marquez VE, Nicklaus MC, Mitsuya H, Barchi JJ.
Conformationally locked nucleoside analogues. Synthesis of dideoxycarbocyclic nucleoside analogues structurally related to neplanocin C.
J Med Chem. 37: 3389-99, 1994. [Journal]
69)  Milne GW, Nicklaus MC, Driscoll JS, Wang S, Zaharevitz D.
National Cancer Institute Drug Information System 3D database.
J Chem Inf Comput Sci. 34: 1219-24, 1994. [Journal]
70)  Wang S, Milne GW, Nicklaus MC, Marquez VE, Lee J, Blumberg PM.
Protein kinase C. Modeling of the binding site and prediction of binding constants.
J Med Chem. 37: 1326-38, 1994. [Journal]
71)  Rodriguez JB, Marquez VE, Nicklaus MC, Mitsuya H, Barchi JJ.
Synthesis of Cyclopropane-fused Dideoxycarbocyclic Nucleosides Structurally Related to Neplanocin-C.
Tet Lett. 34: 6233-6236, 1993. [Journal]
72)  Nicklaus MC, Milne GW, Zaharevitz D.
Chem-X and CAMBRIDGE. Comparison of computer generated chemical structures with X-ray crystallographic data.
J Chem Inf Comput Sci. 33: 639-46, 1993. [Journal]
73)  Milne GWA, Nicklaus MC, Hodoscek M.
Molecular modeling in solvent.
J Mol Struct. 291: 89-103, 1993. [Journal]
74)  Nicklaus MC, Milne GW, Zaharevitz D.
Concord and Cambridge - Comparison of Computer-Generated Chemical Structures with X-Ray Crystallographic Data.
J Chem Inf Comput Sci. 33: 155-163, 1993. [Journal]
75)  Milne GW, Nicklaus MC.
Use of computer graphics in drug design.
NIDA Res Monogr. 134: 129-45, 1993. [Journal]
76)  Nicklaus MC, Milne GW, Burke TR.
QSAR of conformationally flexible molecules: comparative molecular field analysis of protein-tyrosine kinase inhibitors.
J Comput Aided Mol Des. 6: 487-504, 1992. [Journal]
77)  Sun G, Nicklaus MC.
Natural Resonance Structures and Aromaticity of the Nucleobases.
Theor. Chem. Acc. 117: 323-332, 2007. [Journal]

This page was last updated on 9/29/2008.