The DI is comprised of 13 offices. Four offices concentrate on regional political and economic issues, six examine broad transnational issues, and three focus on policy, collection, and staff support. The DI also supports a selection of other analytic programs.

• The CIA Crime and Narcotics Center collects and analyzes information on international narcotics trafficking and organized crime for policymakers and the law enforcement community.
• The CIA Weapons, Intelligence, Nonproliferation, and Arms Control Center provides intelligence support aimed at doing all it can to protect America from the strategic threat of foreign weapons.
• The Counterintelligence Center Analysis Group identifies, monitors, and analyzes the efforts of foreign intelligence entities against US persons, activities, and interests.
• The Information Operations Center Analysis Group evaluates foreign threats to US computer systems, particularly those that support critical infrastructures.
• The Office of Asian Pacific, Latin American, and African Analysis studies the political, economic, leadership, societal, and military developments in Asia, Latin America, and Sub-saharan Africa.
• The Office of Collection Strategies and Analysis provides comprehensive intelligence collection expertise to the DI, a wide range of senior Agency and Intelligence Community officials, and key national policymakers.
• The Office of Corporate Resources oversees support to the directorate on a wide variety of issues, including budget, contracts, diversity programs, equal employment opportunity, facilities management, human resources, and resource planning.
  
• The Office of Iraq Analysis provides multidisciplinary intelligence analysis on Iraq to the President and his top advisors.
• The Office of Near Eastern and South Asian Analysis provides policymakers with comprehensive analytic support on Middle Eastern and North African countries, as well as on the South Asian nations of India, Pakistan, and Afghanistan.
• The Office of Policy Support customizes DI analysis and presents it to a wide variety of policy, law enforcement, military, and foreign liaison recipients.
• The Office of Russian and European Analysis provides intelligence support on a large number of countries that have long been of crucial importance to the United States as allies or as adversaries and are likely to continue to occupy a key place in US national security policy.
• The Office of Terrorism Analysis is the analytic component of the CIA Counterterrorism Center.
• The Office of Transnational Issues applies unique functional expertise to assess existing and emerging threats to US national security and provides the most senior US policymakers, military planners, and law enforcement with analysis, warning, and crisis support.

Other Analytic Programs

• The Sherman Kent School for Intelligence Analysis provides education for new analysts and experts alike. 
• The Political Islam Strategic Analysis Program examines those movements and organizations that use religion for political purposes and use religious ideology to attempt to change the existing political, social, or economic order. The effort does not focus on Islam as a religion or on the worldwide Muslim community.