 |
|
OGX-011
A mixed-backbone antisense oligodeoxynucleotide with chemosensitizing properties. OGX-011 inhibits testosterone-repressed prostate message-2 (TRPM-2). Administration of OGX-011 abrogates the anti-apoptotic effect of TRPM-2, thereby sensitizing cells to chemotherapy and resulting in tumor cell death. TRPM-2 is an anti-apoptotic clusterin that is overexpressed by prostate cancer cells and is associated with chemoresistance. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | Antisense Clusterin
Antisense Testosterone-Repressed Prostate Message 2
Antisense TRPM-2
clusterin antisense oligonucleotide
ISIS 112989
TRPM-2 Antisense | | |
|
|
