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pertuzumab A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20081005062550im_/http://www.nci.nih.gov/images/spacer.gif) | 2C4 antibody monoclonal antibody 2C4 rhuMAb-2C4 | | ![](https://webarchive.library.unt.edu/eot2008/20081005062550im_/http://www.nci.nih.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20081005062550im_/http://www.nci.nih.gov/images/spacer.gif) | Omnitarg | | ![](https://webarchive.library.unt.edu/eot2008/20081005062550im_/http://www.nci.nih.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081005062550im_/http://www.nci.nih.gov/images/spacer.gif) | MOAB 2C4 | | ![](https://webarchive.library.unt.edu/eot2008/20081005062550im_/http://www.nci.nih.gov/images/spacer.gif) |
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