Breast and Colon Cancer Family Registries
For Research Collaborators: Scientific Session
Breast and Colon Cancer Family Registry Scientific Session
Monday, December 5, 2005
Bethesda, Maryland
 Welcome
and NCI Introduction
Daniela Seminara, Ph.D., M.P.H., Program Director,
Division of Cancer Control and Population Sciences, National Cancer Institute |
 Robert Croyle, Ph.D., Director,
Division of Cancer Control and Population Sciences, National Cancer
Institute |
 Introduction
Ed Trapido, Ph.D., Sc.D., Associate Director,
Epidemiology and Genetics Research Program,
Division of Cancer Control and Population Sciences, National Cancer Institute |
| |
Colon Cancer Family Registry
(CFR) Research Updates |
 Introduction
and Overview of Colon Cancer Family Registry (CFR) Research
Robert Haile, Dr.P.H., Professor/Director,
Genetic Epidemiology Program, Keck School of Medicine,
University of Southern California |
|
Mismatch Repair (MMR) Gene-Related Research |
| |
 Guanosine
Monophosphate (GMP) Study
Graham Casey, Ph.D., Staff,
Department of Cancer Biology, Lerner Research Institute,
Cleveland Clinic Foundation |
| |
 Amsterdam
Study
Laney Lindor, M.D., Associate Professor of Medical Genetics,
Mayo Clinic
Postmeiotic Segregation Increased 2 (PMS2) Study
Laney Lindor, M.D., Associate Professor of Medical
Genetics,
Mayo Clinic |
| |
 MutS
Homolog 6 (MSH6) Study
Steve Thibodeau, Ph.D., Lab Director,
Laboratory Genetics, Mayo Clinic
Multiple
Ligation-Dependent Probe Amplification (MLPA) Study
Steve Thibodeau, Ph.D., Lab Director,
Laboratory Genetics, Mayo Clinic |
| |
 Pathology/Bethesda
Criteria
Jeremy Jass, M.D., Professor,
Pathology Department, McGill University |
| |
 Mismatch
Repair (MMR) Penetrance
Mark Jenkins, Ph.D., Senior Lecturer,
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology,
The University of Melbourne |
 Metabolic
Pathways
John Potter, M.D., Ph.D., Senior Vice President
and Director,
Public Health Sciences, Fred Hutchinson Cancer Research Center |
Modeling
Approaches to Metabolic Pathways
Duncan Thomas, Ph.D., Professor Co-Director Biostatistics
Division,
Keck School of Medicine, University of California |
 Ontario
Myosin Heavy Chains (MYH) Analysis and CFR-wide Preliminary Data
Steve Gallinger, M.D., Principal Investigator,
Ontario Colon CFR, Ontario Familial Colorectal Cancer Registry,
Mount Sinai Hospital, University of Toronto |
 CpG Island Methylator Phenotype (CIMP) and Methylation Research
Peter Laird, Ph.D., Associate Professor,
University of Southern California |
 Collaborations
With the Cancer Family Registry (CFR) on the Pathogenesis of Syndrome
X
C. Richard Boland, M.D., Chief,
Division of Gastroenterology, Baylor University Medical Center |
 Studies
in Transforming Growth Factor beta (TGF-beta) Pathways (Breast
and Colon)
Boris Pasche, M.D., Ph.D., FACP, Director,
Cancer Genetics Program, Department of Hematology/Oncology,
Northwestern University Feinberg School of Medicine |
| |
Joint Genomewide Association Studies |
Overview
of Analytical Methods
Duncan Thomas, Ph.D. (pictured above),
Professor Co-Director Biostatistics Division,
Keck School of Medicine, University of California |
 Breast
Cancer Family Registry (CFR) Genomewide Association Project
Habib Ahsan, M.D., M.Med.Sc., Associate Professor/Director,
Center for Genetics in Epidemiology, Mailman School of Public Health, Columbia
University |
Colon
Cancer Family Registry (CFR) Genomewide Association Project
Graham Casey, Ph.D. (pictured above), Staff,
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation |
 Assessment
of Risk for Colorectal Tumors (ARCTIC)
Brent Zanke, M.D., Ph.D., FRCPC, Provincial Head,
Systemic Therapy,
Vice President, Ontario Cancer Research Network,
Cancer Care Ontario & Ontario Cancer Research Network |
| |
Breast Cancer Family Registry (CFR) Research
Updates |
 Introduction
and Overview of Research
Irene Andrulis, Ph.D., Director,
Ontario Cancer Genetics Network, Cancer Care Ontario |
 Cancer
Risks in Relatives of Patients With Breast or Ovarian Cancer
Alice Whittemore, Ph.D., Professor,
School of Medicine, Stanford University |
 Minority
Families in the Breast Cancer Family Registry—Resources and
Ongoing Research
Esther John, Ph.D., Research Scientist,
Department of Epidemiology, Northern California Cancer Center |
 Ethnocultural
Study
Mary Daly, Ph.D., Director,
Cancer Prevention and Control, Fox Chase Cancer Center |
Breast Cancer Histopathologic Phenotype and Biomarker
Frances O’Malley, M.D.,
Department of Pathology, Mount Sinai Hospital |
 Mutations
in Cytochrome P450c17alpha gene (CYP17) and Other Hormone Metabolism
Genes and Risk of Breast Cancer
John Hopper, Ph.D., M.Sc., Director,
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology,
The University of Melbourne |
 Breast
Cancer 1 Gene (BRCA1) and Breast Cancer 2 Gene (BRCA2)
Mutation Screening in the Breast Cancer Family Registry (CFR)
Melissa Southey, Ph.D., Scientist,
International Agency for Research on Cancer |
 Epidemiologic
Risk Factor and Tumor Characteristics
Mary Beth Terry, Ph.D., Assistant Professor,
Columbia University |
 Checkpoint Kinase 2 (CHEK2) and Ataxia-Telangiectasia Mutated Gene (ATM)
Jonine Bernstein, Ph.D., Associate Attending Epidemiologist,
Department of Epidemiology, Memorial Sloan-Kettering Cancer Center |
 Smoking
and Risk of Breast Cancer in Carriers
Norman Boyd, M.D., D.Sc., FRCPC, Senior Scientist,
Ontario Cancer Institute |
 Alcohol
Gene-Environmental Study
Julia Knight, Ph.D., Investigator,
Samuel Lunenfeld Research Institute, Mount Sinai Hospital |
Bioinformatics
Applications for Breast and Colon Cancer Family Registries (BC-CFR)
David Hall, Ph.D., Bioinformatician,
Research Triangle Institute |
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