=> DATA FILE SET-LEVEL: SRC94A02
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=> indicates the hierarchical level of the current display Further description of the hierarchical organization of CEDR Structured Documentation
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Description:
This analytic data file set consists of two files generated for a retrospective cohort mortality study by Donna Cragle, et al., of white males employed at the Savannah River Site (SRS) in Aiken, South Carolina in 1952-1974.
A previous study (Cragle et al, 1988. American Journal of Industrial Medicine 14: 379-401) of 9,860 white males was descriptive in nature because radiation doses were not accessible for dose-response analysis. Men first hired from the plant opening in 1952 through 1974 entered the study 90 days after hire and were followed up through 1980. For hourly workers, there were 13 leukemia deaths versus the 7.95 expected based on U.S. white male rates. Overall there was a strong healthy worker effect evident with standardized mortality ratios (SMRs) significantly below one for all causes (0.80) and all cancers (0.72). The current update was based on deaths through 1986 for the same cohort of workers. With the 6 additional years, there was a total of 290,000 person-years of follow-up. For hourly workers there were 19 leukemia deaths, giving an SMR of 1.34 with a 95% confidence interval from 0.80 to 2.09. The healthy worker effect was still evident with SMRs significantly below one for all causes (0.78) and all cancers (0.82). Dose-response analysis was performed for all cancers, lung cancer, leukemia, colon cancer, and pancreatic cancer. There was no indication of a dose-response relationship except for leukemia. However, the leukemia dose-response relationship was based on only 20 deaths, including two nonunderlying causes of death and excluding chronic lymphocytic leukemia, which has not been linked to radiation exposure.
There are two analytic files for this cohort. DLC9860 contains a record, which includes vital status as of January 1, 1987, for each member of the cohort. The last Social Security Administration (SSA) submission for this population provided "alive" status as of January 1, 1985; the "alive" category is no longer obtainable from SSA. However, the National Death Index (NDI) provides a record of all deaths occurring since January 1, 1979. If not identified as deceased by SSA or NDI, individuals last known to be alive before January 1, 1979, were considered lost to follow-up on the last date known alive while those known to be alive after January 1, 1979, were considered alive at the end of the study. There were 1,722 deaths from all causes with death certificates available for 97.9% of these individuals. The exposure file (SRSEXPOS) contains yearly dose values for all monitored workers, including 9,757 of the workers for external radiation exposure and 455 for internal exposures due to transuranics or fission products. The annual external doses are more accurately "deep" doses resulting from exposures to photons, neutrons, and tritium.
The SRS was built after World War II and was specifically designed for nuclear operations. Operations at the SRS have included uranium processing, nuclear fuel fabrication, nuclear reactor operation and maintenance, nuclear fuel reprocessing, and thorium processing. The site contains five large production reactors, two chemical separation facilities, a heavy water extraction plant, nuclear fuel and target fabrication facilities, test reactors, research and development laboratories, power plants, and administration buildings.
Number of data files: 2
Cohort Size: 9860
Providing Organization: Oak Ridge Institute for Science and Education/CER
Races: White
Sexes: male
Diseases: ALL
Earliest Exposure: 01/01/1952
Latest Exposure: 12/31/1986
Follow-Up: 12/31/1986
Exposure Type: external radiation, internal radiation
Exposure Agent: uranium, thorium, ...
Sites: Savannah River
Contact Information:
Cragle, Dr. Donna
(423) 576-2866
Fax: 423 576-9557
Email: cragled@orau.gov