The Office of the Assistant Secretary for Mental Health and Substance Use is responsible to the Secretary of the Department of Health and Human Services for managing and directing SAMHSA. The Office of the Assistant Secretary for Mental Health and Substance Use: Works with HHS Office of the Secretary on matters related to programs and other activities Manages and directs SAMHSA Leads SAMHSA policy and program development Contact Information Office of the Assistant Secretary for Mental Health and Substance Use 5600 Fishers Lane Rockville, MD 20857 240-276-2000