Available Technologies for Licensing and Collaboration
Gastrointestinal Diseases
Rotavirus
CDC Global photo.
A Novel Thermal Method to Inactivate Rotavirus for Use in Vaccinesexternal icon
- Controlled Expression and Assembly of Human Group-C Rotavirus-like Particles for Creation of Rotavirus Diagnostic Assays and Improved Vaccine Formulationsexternal icon
- Human Rotavirus Strains and Vaccines for Neonatal Childhood Protectionexternal icon
- Novel Human Rotavirus Vaccine CDC-6 Strain for Impacted Subgroup, the Lewis Negative Populationexternal icon
Respiratory Diseases
Anthrax (caused by Bacillus anthracis)
- Linear Epitopes of Anthrax Toxin Protective Antigen (PA) for Development of a Peptide Vaccineexternal icon
- Stable, Early-stage Biomarker for Diagnosis of Bacillus anthracis Infection and Anthrax Vaccine Developmentexternal icon
- Novel Epitopes of Bacillus anthracis Lethal Factor for Development of Diagnostics and Therapeuticsexternal icon
General/Multi-purpose Respiratory
- Improved Protein Quantification Process and Vaccine Quality Control Productionexternal icon
- Intranasal Dry Powder Inhaler for Improved Delivery of Vaccines and Therapeuticsexternal icon
- Intranasal Nebulizer with Disposable Drug Cartridge for Improved Delivery of Vaccines and Therapeuticsexternal icon
- Methods for Amelioration and Treatment of Pathogen-associated Inflammatory Responseexternal icon
- Virus Microneutralization Assay Data Analysis for Vaccine Development, Enhancement and Efficacy Improvementexternal icon
Influenza
- New Anti-Influenza Virus Neuraminidase 9 (N9) Monoclonal Antibody – for Prevention or Treatment of H7N9 Influenza (Flu) A with Less Likelihood of Drug Resistanceexternal icon
- MDCK-based Reporter System for Detection of Influenza Viruses, Antiviral Drug Screening, and Analysis of Neutralizing Antibodiesexternal icon
Pneumonia
- Peptide Sequences for Chlamydophila pneumoniae Vaccine and Serological Diagnosisexternal icon
- Antigen, Encoding Gene, Related Monoclonal Antibody and Hybridoma Clones for Streptococcus pneumoniae Serological Diagnosticsexternal icon
- Encapsulated Streptococcus Compositions and Methods for Pneumococcal Vaccine, Probiotic, and Diagnostic Assay Developmentexternal icon
- Multi-Antigenic Peptide(s) Vaccine and Immunogen for Conferring Streptococcus pneumoniae Immunityexternal icon
- Novel Peptide of Streptococcus pneumoniae Surface Adhesion A (PsaA) Protein Associated with Adherence and Uses Thereof – for Vaccine Candidate, Therapeutic and Diagnostic Developmentexternal icon
- Peptide Vaccines Against Group A Streptococciexternal icon
Respiratory Syncytial Virus (RSV)
- CD40 Ligand: Adjuvant for Enhanced Immune Response to Respiratory Syncytial Virusexternal icon
- Respiratory Syncytial Virus Immunogens for Vaccine and Therapeutics Developmentexternal icon
Tuberculosis
Sexually Transmitted Diseases
HIV
- Inhibition of HIV Infection through Chemoprophylaxis Using Emtricitabine and Tenofovirexternal icon
- HIV-1 Multi-Clade, Multivalent Recombinant Vaccine Constructexternal icon
Simian HIV (SHIV)
Tropical, Emerging, & Zoonotic Diseases
Crimean-Congo
Dengue-Specific
Ebola
Flaviviruses (including Dengue, Zika and West Nile Viruses)
- Chimeric Dengue/Zika Viruses for Live-Attenuated Zika Vaccine Developmentexternal icon
- Dengue Vaccines: Tools for Redirecting the Immune Response for Safe, Efficacious Dengue Vaccinationexternal icon
- Discrete Cross-Reactive Epitopes for Flavivirus Serological Diagnostics and Vaccinesexternal icon
- High-Titer, Fast-Growth Chimeric Dengue/West Nile Viruses for Vaccine and Diagnostics Developmentexternal icon
- Polypeptides and Methods for Enhancing and Balancing Monovalent or Multivalent Flavivirus Vaccinesexternal icon
- Recombinant Nucleic-Acid Based Flavivirus Nucleic Acids for Development of Vaccines and/or Sero-diagnosticsexternal icon
- West Nile/Zika Virus Chimeras for Inactivated Zika Vaccine and Diagnostic Assay Developmentexternal icon
- Zika Virus VLP (Virus-like Particle) Antigens for Vaccine Candidate and Diagnostic Developmentexternal icon
Heartland Virus
Lyme
Rabies
- Antigen-capture Electrochemiluminescent Assay for Determining Rabies Vaccine Potencyexternal icon
- Antibodies for Rabies Post-exposure Prophylaxis or Antiviral Therapy of Clinical Rabiesexternal icon
- Novel Live-Attenuated Rabies Vaccineexternal icon
- Novel Recombinant Rabies Vaccine Also Capable of Immunocontraceptionexternal icon
- Recombinant Pan-Lyssavirus for Use in Rabies and Broad-Lyssavirus Vaccinationexternal icon
- Rabies Vaccine for the Oral Immunization of Domesticated Animals, Wildlife and Feral Animalsexternal icon
Rift Valley Fever
- Novel Rift Valley Fever Virus Vaccinesexternal icon
- Virus Replicon Particles (VRPs) as Rift Valley Fever Vaccinesexternal icon
Zika Virus
- Chimeric Dengue/Zika Viruses for Live-Attenuated Zika Vaccine Developmentexternal icon
- West Nile/Zika Virus Chimeras for Inactivated Zika Vaccine and Diagnostic Assay Developmentexternal icon
- Zika Virus VLP (Virus-like Particle) Antigens for Vaccine Candidate and Diagnostic Developmentexternal icon
Other Infectious Diseases
- Diagnostics, Vaccines, and Delivery-Vehicles Related to Novel Phlebovirusexternal icon
- Immunogenic Hepatitis E Virus Polypeptides for Vaccine and Diagnostics Developmentexternal icon
- Method of Enhancing the Human Immune Response (Opsonophagocytosis) to Fight Infectionexternal icon
- Novel Primate T-cell Lymphotropic Viruses (HTLV, STLV) for Development of Diagnostics, Therapeutics, Research Toolsexternal icon
- Encapsulated Streptococcus Compositions and Methods for Pneumococcal Vaccine, Probiotic, and Diagnostic Assay Development – for other pneumococcal conditions (e.g., ear infections, meningitis, and bacteremia)external icon
- Therapeutic, Bifunctional Janus Microparticles with Spatially Segregated Surface Proteins and Methods of Productionexternal icon
- Vaccine Attenuation via Deoptimization of Synonymous Codonsexternal icon
![flu_viruses The image shows an assay to characterize influenza viruses. CDC PHIL photo, Todd Jordan.](https://webarchive.library.unt.edu/web/20201221164815im_/https://www.cdc.gov/os/technology/techtransfer/industry/licensing/flu_viruses-small.jpg)
CDC PHIL photo, Todd Jordan.
Diagnostics
Antibiotic/Antimicrobial Resistance
- DNA Probes to Rapidly Screen Candida glabrata Isolates for Echinocandin Resistance to Antifungal Treatmentexternal icon
- Real-Time PCR Assay for Detection of Carbapenem Antibiotic Resistance Genes of the IMP-typeexternal icon
Fungal/Fungi Detection
- Detection and Differentiation of Pathogenic Fungi in Clinical Samples Using a Multi-Analyte Profiling Systemexternal icon
- Nucleic Acid Assays for the Detection and Discrimination of Aspergillus Fungi Species within Biological Samplesexternal icon
- Nucleic Acid-based Compositions and Methods for the Detection of Pathogenic Candida or Aspergillus Fungi Speciesexternal icon
- Nucleic Acid-based Compositions and Methods for the Species-Specific Detection of Pathogenic Candida Fungiexternal icon
- Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samplesexternal icon
- Nucleic Acid-based Differentiation and Identification of Medically Important Fungiexternal icon
- Species-specific Nucleic Acid Detection Assay for Fungiexternal icon
Gastrointestinal/Enteric
- Controlled Expression and Assembly of Human Group-C Rotavirus-like Particles for Creation of Rotavirus Diagnostic Assays and Improved Vaccine Formulationsexternal icon
- Diagnostic Assays Utilizing Real-Time Taqman or Seminested RT-PCR for Parechovirus Detection and Discriminationexternal icon
- Multiplex Assay for Rapid Salmonella Serotyping from Human, Animal, Food and Environmental Sourcesexternal icon
- Multiplex Real-time PCR Assay for Detection of Numerous Bacterial Pathogens Important in Neonatal Infection and Food Safetyexternal icon
- Novel Human Rotavirus Vaccine CDC-6 Strain for Impacted Subgroup, the Lewis Negative Populationexternal icon
- One-step random amplification method to detect extremely low input nucleic acids for virome, microbiome, and metagenomics in clinical and biological specimensexternal icon — Thus far, CDC has achieved whole genome sequencing of a variety of viruses directly from clinical specimens, including but not limited to enterovirus (EV-D68, CV-A24, and EV-A71), cosavirus, parechovirus, and norovirus
- Recombinant Polypeptides for Clinical Detection of Taenia solium and Diagnosis of Cysticercosisexternal icon
- Real-Time RT-PCR Assay for Detection of Norovirusesexternal icon
- Real-time RT-PCR Assay for Rapid, Highly Sensitive and Specific Detection of Human Enterovirus D68 (EV-D68)external icon
- Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasmaexternal icon
Hepatitis
- Immunogenic Hepatitis E Virus Polypeptides for Vaccine and Diagnostics Developmentexternal icon
- Novel Enzyme-Based Immunoassay for Simultaneous Detection of Hepatitis C Virus Antigen and Antibody in Human Serum or Plasmaexternal icon
- Real-time RT-PCR Assay For Detection and Quantification of Hepatitis D Virus Infectionexternal icon
Rabies and Lyssaviruses
- Antigen-capture Electrochemiluminescent Assay for Determining Rabies Vaccine Potencyexternal icon
- High-throughput assay for detection of rabies neutralizing antibodiesexternal icon
- Isolated Lyssavirus Nucleic Acid and Protein Sequencesexternal icon
- Real-Time RT-PCR Assay for the Rapid Detection of Rabies and Other Lyssavirusesexternal icon
Respiratory
Respiratory – Anthrax
- Assay for Early Diagnosis of Anthrax Using Monoclonal Antibodies Against Anthrax Toxinexternal icon
- Exposure and Activity Detection Assays for Anthrax Lethal Factor and Lethal Toxinexternal icon
- Novel Epitopes of Bacillus anthracis Lethal Factor for Development of Diagnostics and Therapeuticsexternal icon
- Stable, Early-stage Biomarker for Diagnosis of Bacillus anthracis Infection and Anthrax Vaccine Developmentexternal icon
- Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasmaexternal icon
Respiratory – Enterovirus
Respiratory – Fungal/Fungi including Candida
- Nucleic Acid-based Compositions and Methods for the Detection of Pathogenic Candida or Aspergillus Fungi Speciesexternal icon
- Nucleic Acid-based Compositions and Methods for the Species-Specific Detection of Pathogenic Candida Fungiexternal icon
- Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samplesexternal icon
Respiratory – Influenza
- Human Influenza Virus Real-time RT-PCR: Detection and Discrimination of Influenza A (H3N2) Variant from Seasonal…external icon
- Immunoassay for the Simultaneous Detection of Functional Antibodies against Multiple Serotypes of Streptococcus…external icon
- Influenza A Virus Detection and Subtyping Directly from Animal Swabs and Environmental Samplesexternal icon
- MDCK-based Reporter System for Detection of Influenza Viruses, Antiviral Drug Screening, and Analysis of Neutralizing Antibodiesexternal icon
- Methods of Detecting and Identifying Both Known and Novel Influenza Virusesexternal icon
- New Anti-Influenza Virus Neuraminidase 9 (N9) Monoclonal Antibody – for Prevention or Treatment of H7N9 Influenza (Flu) A with Less Likelihood of Drug Resistanceexternal icon
- Real-time RT-PCR Assay for Detection of Live Attenuated Influenza Vaccine for A and B Virusesexternal icon
- Real-Time RT-PCR Assay for Influenza B Lineage Characterizationexternal icon
- Real-Time PCR Assay for Specific Detection of Haemophilus influenza Serotypes A and Bexternal icon
- Real-time RT-PCR Detection and Characterization Panel for Human Influenza Virusexternal icon
- Real-time RT-PCR: Detection and Discrimination of Human Influenza A (H3N2) Variant from Seasonal Influenza A (H3N2) Viruses, Including H3v and Seasonal H3 Assaysexternal icon
- The CDC 2009 Influenza A H1N1 (Flu) Pandemic Real-time RT-PCR Panel including Pandemic Influenza A and Pandemic H1 Assaysexternal icon
Respiratory – Legionella
Respiratory – Pertussis
- Real-time PCR Assays for Selective Detection and Differentiation of B. pertussis, B. parapertussis and B. homesiiexternal icon
- Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasmaexternal icon
Respiratory – Pneumonia
- Antigen, Encoding Gene, Related Monoclonal Antibody and Hybridoma Clones for Streptococcus pneumoniae Serological Diagnosticsexternal icon
- Encapsulated Streptococcus Compositions and Methods for Pneumococcal Vaccine, Probiotic, and Diagnostic Assay Developmentexternal icon
- Immunoassay for the Simultaneous Detection of Functional Antibodies against Multiple Serotypes of Streptococcus pneumonia and Other Bacteria Typesexternal icon
- Multi-Antigenic Peptide(s) Vaccine and Immunogen for Conferring Streptococcus pneumonia Immunityexternal icon
- Novel Peptide of Streptococcus pneumonia Surface Adhesion A (PsaA) Protein Associated with Adherence and Uses Thereof – for Vaccine Candidate, Therapeutic and Diagnostic Developmentexternal icon
- Peptide Sequences for Chlamydophila pneumonia Vaccine and Serological Diagnosisexternal icon
- Peptide Vaccines Against Group A Streptococciexternal icon
- Real-time PCR and High Resolution Melt Analysis for Genotyping of Pneumonia Type – Chlamydophila psittaciexternal icon
- Real-time PCR Detection of Streptococcus pneumonia with High Sensitivity and Specificityexternal icon
- Real-time PCR Assay for Detection of Pneumococcal DNA and Diagnosis of Pneumococcal Diseaseexternal icon
- Simple and Rapid Loop-Mediated Isothermal Amplification (LAMP)-based Assay for Mycoplasma pneumoniae Detectionexternal icon
Respiratory – Tuberculosis
- Diagnostic Antigens for the Identification of Latent Tuberculosis Infectionexternal icon
- Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis for Tuberculosis, Malaria and Other Infectious Diseasesexternal icon
- Rapid Detection of Multi-Drug-Resistant Mycobacterium tuberculosis Using Real-Time PCR and High-Resolution Melt Analysisexternal icon
Respiratory – Other
- Detection of Stachybotrys chartarum (a Type of Fungus/Black Mold) with Monoclonal Antibodiesexternal icon
- Diagnostic Assays Utilizing Real-Time Taqman or Seminested RT-PCR for Parechovirus Detection and Discriminationexternal icon
- Methods for the Simultaneous Detection of Multiple Analytesexternal icon
- Multiplex Real-time PCR Assay for Detection of Numerous Bacterial Pathogensexternal icon
- Personal Air Sampler for Collecting Airborne Aerosol Particulates for Molecular Analysis by Sizeexternal icon
- Real-time PCR Assays for Human Bocavirus Detection and Diagnosisexternal icon
- Real-time PCR Assays for Selective Detection and Differentiation of B. pertussis, B. parapertussis and B. homesiiexternal icon
- Real-Time PCR Multiplex Assay for Detection of Bacterial Respiratory Pathogens in Clinical Specimensexternal icon
- Real-time TaqMan RT-PCR Assays for Selective Detection of Human Rhinovirusexternal icon
- Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasmaexternal icon
Sexually Transmitted Diseases (STDs)
HIV (Subtypes 1 & 2) and Simian HIV
- Composition and Methods for Rapid Detection of HIV by Loop-mediated Isothermal Amplificationexternal icon
- Detection of Retroviruses and HIV-1 Groups -M and -O Discrimination within Clinical Serum Samplesexternal icon
- HIV-1 BED: A Simple Serological Assay for Detecting Recent Infection and Estimating Incidence of Multiple, Worldwide HIV-1 Subtypesexternal icon
- Improved Simian HIV (SHIV) Prevention in Non-human Primate Models with Chemoprophylaxis Combination that Can Be Taken in One or Two Oral Doses Before or After Exposureexternal icon
- Molecular Detection and Viral-Load Quantification for HIV-1 Groups M, N and O, and Simian Immunodeficiency Virus-cpz (SIVcpz)external icon
- Monoclonal Antibodies to the HIV-1 Core Protein p24external icon
- Monoclonal Antibody to Detect the Antiretroviral Drug Emtricitabine – for HIV Drug Adherence Monitoringexternal icon
- Multiple Antigenic Peptide Assay for Detection of HIV or SIV Type Retrovirusesexternal icon
- Multivalent Multiple-Antigenic-Peptides (MAPs) for the Detection of Antibodies to HIV-1 Group M, N, and O, and HIV-2external icon
- Novel One-Well Limiting-Antigen Avidity Enzyme Immunoassay to Detect Recent HIV-1 Infection Using a Multi-subtype Recombinant Protein – please contact TTO at TTO@cdc.gov
- On-site in vitro Diagnostic: Real-time Loop-Mediated Isothermal Amplification Detection of HIV-2 Groups A and Bexternal icon
- Rapid Detection of Antiretroviral(s) Drug-Resistant HIV-1 within Clinical Samplesexternal icon
- Real-Time PCR Assay for HIV-1 Subtype Diagnosis and Global Surveillance of Drug Resistanceexternal icon
- Simian T-Cell Lymphotropic Virus Strain Type 3 (STLV-3) Subtype D Variant, a Highly Divergent STLV-3, for Development of Diagnostics, Therapeutics, Vaccines and Research Tools – please contact TTO at TTO@cdc.gov
- Simple and Rapid Assay to Detect Acute Subtype B and Group M HIV-1 Infectionsexternal icon
- Simple, Rapid, and Sensitive Real-Time PCR Assays for Detecting Drug Resistance in Human Immunodeficiency Viruses (HIV)external icon
Syphilis
- Cardiolipin Modification for Immunoassay Detection of Syphilisexternal icon
- Diagnostic Assay with Modified Cardiolipin for Detecting Active Syphilis Infectionsexternal icon
- Immunoassays and Methods to Diagnose Syphilis by Immobilizing a Lipoidal Antigen on a Solid Supportexternal icon
- Methods for Detecting Syphilis Using Synthetic Antigensexternal icon
Tropical/Emerging Diseases (Includes Flaviruses)
- Chimeric Dengue/Zika Viruses for Live-Attenuated Zika Vaccine (and Diagnostic) Developmentexternal icon
- Chimeric Reporter West Nile/Dengue Viruses and Their Use for Assay Developmentexternal icon
- CDC Trioplex Real-Time RT-PCR Assay for Detection and Differentiation of Zika, Dengue, & Chikungunya Virusexternal icon
- Discrete Cross-Reactive Epitopes for Flavivirus Serological Diagnostics and Vaccinesexternal icon
- Heartland Virus Humanized Monoclonal Antibodies for Diagnostic and Therapeutic Developmentexternal icon
- High-Titer, Fast-Growth Chimeric Dengue/West Nile Viruses for Vaccine and Diagnostics Developmentexternal icon
- Monoclonal Antibodies for Specific Detection of Dengue Virus Sub-type 4 in Human Serumexternal icon
- Monoclonal Antibodies that Bind Zika Virus Envelope Protein for Zika Diagnostics and Researchexternal icon
- Multiplex Assay for Detection of Dengue Virusexternal icon
- Novel Fourth Human Ebolavirus species, Bundibugyo ebolavirus – Compositions and Methods for Vaccine, Therapeutics and Highly Sensitive Diagnostic Assay Developmentexternal icon
- Novel Method and Kit Using Monoclonal Antibodies for More Sensitive Detection of Dengue Virusexternal icon
- Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis for Malaria, Tuberculosis and Other Infectious Diseasesexternal icon
- Nucleic Acid Primers and Probes for Detecting Ebola Virus (species Zaire ebolavirus)external icon
- Rapid Colorimetric Detection of Zika Virus from Serum and Urine Specimens by RT-LAMP (Reverse Transcription Loop-Mediated Isothermal Amplification)external icon
- Real-Time RT-PCR Detection of Rickettsia species — PanR6/Total Nucleic Acid Assay with High Sensitivity and Specificityexternal icon
- Real-Time RT-PCR Detection of Scrub Typhus Total Nucleic Acid Assay with High Sensitivity and Specificityexternal icon
- Recombinant Nucleic-Acid Based Flavivirus Nucleic Acids for Development of Vaccines and/or Sero-diagnosticsexternal icon
- Simple, Field-Usable Fluorescence-Based Isothermal LAMP Assay for the On-Site Diagnosis of Malariaexternal icon
- Use of Vitronectin as a Biomarker for the Detection of a Dengue Hemorrhagic Feverexternal icon
- West Nile/Zika Virus Chimeras for Inactivated Zika Vaccine and Diagnostic Assay Developmentexternal icon
- Zika Virus NS1 Protein Monoclonal Antibodies for Research, Development, and Novel Diagnosticsexternal icon
- Zika Virus VLP (Virus-like Particle) Antigens for Vaccine Candidate and Diagnostic Developmentexternal icon
Other
- Compositions and Methods for Improved Lyme Disease Diagnosisexternal icon
- Diagnostics, Vaccines, and Delivery-Vehicles Related to Novel Phlebovirusexternal icon
- Encapsulated Streptococcus Compositions and Methods for Pneumococcal Vaccine, Probiotic, and Diagnostic Assay Developmentexternal icon – potential commercial application for other pneumococcal conditions (e.g., ear infections, meningitis, and bacteremia)
- Generation of Artificial Mutation Controls for Diagnostic Testingexternal icon
- Human Retrovirus (Spumavirus) Obtained from Infected Chimpanzee Exposureexternal icon
- Improved Botulism, Botulinum Neurotoxin Type-E Diagnosticsexternal icon
- Method to Remove Human DNA When Sequencing for Parasite Infectionexternal icon
- Method to Remove Mycoplasma Contamination from Virus Stocksexternal icon
- Microbial Testing – Photo-induced Electron Transfer Fluorescent Primer for Nucleic Acid Amplificationexternal icon
- Monitoring Public Water Supply for a Variety of Pathogensexternal icon
- Multiplexed Immunoassay for Rapid Serological Diagnosis of a Specific Viral Infection in Clinical Samplesexternal icon
- Multiplex Real-time PCR Assay for Detection of Numerous Bacterial Pathogens Important in Neonatal Infection and Food Safetyexternal icon
- Novel Primate T-cell Lymphotropic Viruses (HTLV, STLV) for Development of Diagnostics, Therapeutics, and Research Toolexternal icons
- Novel UNEX Buffer and Disk for Safe Storage and Transport at Ambient Temperatures of Clinical Specimens for Molecular Testing of Pathogensexternal icon
- Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis for Tuberculosis, Malaria and Other Infectious Diseasesexternal icon
- Portable Laser-Operated Counterfeit Drug Identifier (CoDI) for Tabletsexternal icon
- Rapid Method for the Detection of Antigen-Specific Antibodies in Any Speciesexternal icon
- Real-time RT-PCR Assay for the Detection of Rift Valley Fever Virus in Humans and Livestockexternal icon
- Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasmaexternal icon
- SodC-Based Real-Time PCR Assay for Detection of Neisseria meningitis Infectionexternal icon
- Universal Diagnostic Assay for Detection and Identification of Poxviruses in Clinical Samplesexternal icon
Aerosol Exposure
- Computer Controlled Aerosol Generator with Multi-Walled Carbon Nanotube Inhalation Testing Capabilities external icon
- Non-radioactive, Miniature Bipolar Aerosol Particle Charger for Personal, Portable Instrumentation external icon
Air Quality and Aerosol Analysis
- Air Quality Assurance: A Monitor for Continuous, Simultaneous Analysis of Atmospheric or Aerosolized Particulate Mixturesexternal icon
- Focused Electrostatic Collection of Aerosol Particles for Chemical Analysis by Spectroscopic Techniquesexternal icon
- Inexpensive, Personal Dust Detector Tube/Dosimeter Operating on a Gas Detector Tube Platformexternal icon
- Methods for Near Real-time Chemical Analysis of Aerosols using Microwave-induced Plasma Spectroscopyexternal icon
- Mobile Instrumentation for the Detection and Sampling of Aerosol Particlesexternal icon
- Near Real-time, Low-cost, Hand-held Sensors for Measuring Elemental Concentration of Airborne Particles for Indoor or Outdoor Air Quality Monitoringexternal icon
- Personal Air Sampler for Collecting Airborne Aerosol Particulates for Molecular Analysis by Sizeexternal icon
- Physiologic Sampling Pump Capable of Rapidly Adapting to User Breathing Rateexternal icon
- Silica Exposure Safety: Mini-baghouse Systems and Methods for Controlling Particulate Release from Large Sand Transfer Equipmentexternal icon
Environmental, Public Health or Veterinary/Zoonotic
- Bacterial Pathogen Testing (for Humans & Animals) – Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasmaexternal icon
- Bacterial Pathogen Testing (for Neonatal Infection & Food Safety) – Multiplex Real-time PCR Assay for Detection of Numerous Bacterial Pathogens Important in Neonatal Infection and Food Safetyexternal icon
- Botulinum Diagnostics – Improved Botulism, Botulinum Neurotoxin Type-E Diagnosticsexternal icon
- Counterfeit Drug Detection – A Simple Colorimetric Assay for Anti-malarial Drugs Quality Assurance and Rapid, On-site Counterfeit Detectionexternal icon
- Influenza A Virus Detection – Influenza A Virus Detection and Subtyping Directly from Animal Swabs and Environmental Samplesexternal icon
Disease/Infection Detection external icon
- Biomarker Discovery – Use of Detector Response Curves to Optimize Settings for Mass Spectrometryexternal icon
- Chronic and Infectious Disease Detection – Methods of Retaining Methylation Pattern Information in Globally Amplified DNAexternal icon
- Disease Screening/Diagnostic Testing (for Humans & Other Animals, particularly Birds) – Real-time PCR and High Resolution Melt Analysis for Genotyping of Chlamydophila psittaciexternal icon
- Environmental Safety – Diisocyanate Specific Monoclonal Antibodies for Occupational and Environmental Monitoring of Polyurethane Production Exposure-related Asthma and Allergy and Clinical Diagnosisexternal icon
- Influenza A Virus Detection – Influenza A Virus Detection and Subtyping Directly from Animal Swabs and Environmental Samplesexternal icon
- S. Pneumoniae and Other Infectious Disease Detection – Methods for the Simultaneous Detection of Multiple Analytesexternal icon
Fungal Detection
- Detection and Differentiation of Pathogenic Fungi in Clinical Samples Using a Multi-Analyte Profiling Systemexternal icon
- Monoclonal Antibodies for Detection of Stachybotrys chartarum (a Fungus)external icon
- Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samplesexternal icon
- Nucleic Acid-based Differentiation and Identification of Medically Important Fungiexternal icon
- Nucleic Acid Assays for the Detection and Discrimination of Aspergillus Fungi Species within Biological Samplesexternal icon
- Nucleic Acid-based Compositions and Methods for the Detection of Pathogenic Candida or Aspergillus Fungi Speciesexternal icon
- Nucleic Acid-based Compositions and Methods for the Species-Specific Detection of Pathogenic Candida Fungiexternal icon
- Species-specific Nucleic Acid Detection Assay for Fungiexternal icon
Lead Detection &/or Removal
- Handwipe Disclosing Method for Detecting the Presence of Leadexternal icon
- Wipes and Methods for Removal of Lead and Other Metal Contamination from Surfacesexternal icon
Lyme Disease Diagnostics
Microbial Testing for Water & Public Health
- Fluorescent Primer(s) Creation for Nucleic Acid Detection and Amplificationexternal icon
- Monitoring Public Water Supply for a Variety of Pathogensexternal icon
- Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis/GEARexternal icon
- Photoinduced Electron Transfer Fluorescent Primer for Nucleic Acid Amplificationexternal icon
- Pathogen Detection/Diagnostic for Veterinary – Rapid Method for the Detection of Antigen-Specific Antibodies in Any Speciesexternal icon
- Rift Valley Fever Detection – Real-time RT-PCR Assay for the Detection of Rift Valley Fever Virus in Humans and Livestockexternal icon
- Salmonella Diagnostics/Food Safety – Multiplex Assay for Rapid Salmonella Serotyping from Human, Animal, Food and Environmental Sourcesexternal icon
- Viral Infection Diagnostics – Multiplexed Immunoassay for Rapid Serological Diagnosis of a Specific Viral Infection in Clinical Samplesexternal icon
- Virus Testing Assay for Vaccine Development – Virus Microneutralization Assay Data Analysis for Vaccine Development, Enhancement and Efficacy Improvementexternal icon
Hazard Assessment
Hearing Safety
Mosquito Control including Netting, Repellent, and Traps
- A Bias-free Sampling and Collection Trap for Resting Mosquitoesexternal icon
- CDC Mosquito Trap for Control and Surveillance of Mosquitoes Including Carriers of Zika & Other Virusesexternal icon
- Entangling/Entrapping Synthetic Setae for Control of Insects and Other Pestsexternal icon
- Field-Adapted Spot Test for Evaluating Materials Treated with Permethrin Insect Repellentexternal icon
Musculoskeletal Injury Prevention
Pulmonary Assessment and Respirator Technology
- Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Functionexternal icon
- Mining Safety: Personal Dust Monitor Filters for Accurate, Quantifiable Spectrometric Analysis and Assessment of Worker Exposure Levelsexternal icon
- Respirator Protection Devices and Methods to Detect and Remove Toxic Gases from the Air – Cobinamide Encapsulated Silica-based Materials for Respirator Canistersexternal icon
- Ultrasonic in Situ Respirator Seal-leakage Detection with Real-time Feedback Capabilitiesexternal icon
Water Monitoring
- Fluorescent Primer(s) Creation for Nucleic Acid Detection and Amplificationexternal icon
- Monitoring Public Water Supply for a Variety of Pathogensexternal icon
- Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis/GEARexternal icon
- Photo-induced Electron Transfer Fluorescent Primer for Nucleic Acid Amplificationexternal icon
Occupational Safety and Health Technologies
Aerosol Exposure
- Computer Controlled Aerosol Generator with Multi-Walled Carbon Nanotube Inhalation Testing Capabilitiesexternal icon
- Non-radioactive, Miniature Bipolar Aerosol Particle Charger for Personal, Portable Instrumentationexternal icon
Air Quality and Aerosol Analysis
![Workers_in_construction The image shows four trucks surrounded by dust clouds at a work site.](https://webarchive.library.unt.edu/web/20201221164815im_/https://www.cdc.gov/os/technology/techtransfer/images/Workers_in_construction-small.jpg)
Workers in construction, sandblasting, and mining face significant health risk from the inhalation of silica dust. CDC NIOSH Researchers developed the mini-baghouse retrofit assembly to control the amount of respirable crystalline silica dust released from sand moving machinery by trapping the hazardous particles and reducing air pollution. This retrofit device is an easy to assemble, cost effective solution for existing oil and gas machinery.
CDC NIOSH photo, Michael Breitenstein.
- Air Quality Assurance: A Monitor for Continuous, Simultaneous Analysis of Atmospheric or Aerosolized Particulate Mixturesexternal icon
- Focused Electrostatic Collection of Aerosol Particles for Chemical Analysis by Spectroscopic Techniquesexternal icon
- Inexpensive, Personal Dust Detector Tube/Dosimeter Operating on a Gas Detector Tube Platformexternal icon
- Methods for Near Real-time Chemical Analysis of Aerosols using Microwave-induced Plasma Spectroscopyexternal icon
- Mobile Instrumentation for the Detection and Sampling of Aerosol Particlesexternal icon
- Near Real-time, Low-cost, Hand-held Sensors for Measuring Elemental Concentration of Airborne Particles for Indoor or Outdoor Air Quality Monitoringexternal icon
- Personal Air Sampler for Collecting Airborne Aerosol Particulates for Molecular Analysis by Size external icon
- Physiologic Sampling Pump Capable of Rapidly Adapting to User Breathing Rateexternal icon
- Silica Exposure Safety: Mini-baghouse Systems and Methods for Controlling Particulate Release from Large Sand Transfer Equipmentexternal icon
Asthma and Allergies
Ergonomic and Musculoskeletal Injury Prevention
- Cylindrical Handle Dynamometer for Improved Grip-Strength Measurementexternal icon
- Portable Exposure Assessment System for Prevention of Musculoskeletal Injuryexternal icon
- Wearable Kneel-Sit Support Device for Manual Labor and Heavy Industry Applicationsexternal icon
Fall Prevention
- Adjustable Barricade Safety Rail System and Roof Bracket Assembly to Prevent Worker Fallsexternal icon
- Extension-Ladder Safety: Multimodal-feedback Indicator for Improved Ladder Positioning Safety and Efficiencyexternal icon
Fishing and Maritime Safety
- Cable-line Safety System: Electro/hydraulic Emergency Stop Device for a Winch, Drum or Capstanexternal icon
- Emergency Maritime Battery Chargerexternal icon
- Swing-Away Winch Cathead Guardexternal icon
Hazard Assessment
- Local Positioning System for Position-Time-Condition Correlation, Data-logging and Analysisexternal icon
- Warning System for Mobile Machinery Hazardous Zonesexternal icon
Hearing Safety
Lead Detection and Removal
- Handwipe Disclosing Method for Detecting the Presence of Leadexternal icon
- Wipes and Methods for Removal of Lead and Other Metal Contamination from Surfacesexternal icon
Mining Safety
Mold/Fungus Detection
- Monoclonal Antibodies for Detection of Stachybotrys chartarum (a Fungus)external icon
- Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samplesexternal icon
Patient Isolation
- Mobile Patient Isolation Headboard and Canopy System – *please contact TTO@cdc.gov for more information.
- Ventilated Patient Headboard and Canopy System – *please contact TTO@cdc.gov for more information.
Pulmonary Assessment and Respirator Technology
- Device to Measure Muscle Contractile-Relaxant and Epithelial Bioelectric Responses of Perfused, Intact, Tracheal Airways Tissue In Vitroexternal icon
- Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Functionexternal icon
- Methods and Apparatus for Computer-Aided Cough Sound Analysisexternal icon
- Respirator Protection Devices and Methods to Detect and Remove Toxic Gases from the Air – Cobinamide Encapsulated Silica-based Materials for Respirator Canistersexternal icon
- Ultrasonic in situ Respirator Seal-Leakage Detection with Real-time Feedback Capabilitiesexternal icon
Telemedicine
Aerosol Exposure
- Computer Controlled Aerosol Generator with Multi-Walled Carbon Nanotube Inhalation Testing Capabilitiesexternal icon
- Non-radioactive, Miniature Bipolar Aerosol Particle Charger for Personal, Portable Instrumentationexternal icon
Air Quality and Aerosol Analysis
- Air Quality Assurance: A Monitor for Continuous, Simultaneous Analysis of Atmospheric or Aerosolized Particulate…external icon
- Focused Electrostatic Collection of Aerosol Particles for Chemical Analysis by Spectroscopic Techniquesexternal icon
- Inexpensive, Personal Dust Detector Tube/Dosimeter Operating on a Gas Detector Tube Platformexternal icon
- Methods for Near Real-time Chemical Analysis of Aerosols using Microwave-induced Plasma Spectroscopyexternal icon
- Mobile Instrumentation for the Detection and Sampling of Aerosol Particlesexternal icon
- Personal Air Sampler for Collecting Airborne Aerosol Particulates for Molecular Analysis by Sizeexternal icon
- Physiologic Sampling Pump Capable of Rapidly Adapting to User Breathing Rateexternal icon
- Silica Exposure Safety: Mini-baghouse Systems and Methods for Controlling Particulate Release from Large Sand…external icon
Counterfeit Drug Detection
- A Simple Colorimetric Assay for Anti-malarial Drugs Quality Assurance and Rapid, On-site Counterfeit Detectionexternal icon
- Portable Laser-Operated Counterfeit Drug Identifier (CoDI) for Tabletsexternal icon
Diagnostics
- HIV-1 – A Device for Simultaneous and Rapid Diagnosis and Detection of Recent and Long Term HIV-1 Infectionexternal icon
- Botulism – Improved Botulism, Botulinum Neurotoxin Type-E Diagnosticsexternal icon
- Clostridium difficile (C. difficile), Bordetella pertussis, and more — Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile,…external icon
- Dengue – Novel Method and Kit Using Monoclonal Antibodies for More Sensitive Detection of Dengue Virusexternal icon
- Mass Spectrometry and Biomarker Analysis – Use of Detector Response Curves to Optimize Settings for Mass Spectrometryexternal icon
- Rickettsia – Real-Time RT-PCR Detection of Rickettsia species — PanR6/Total Nucleic Acid Assay with High Sensitivity and Specificityexternal icon
- Scrub Typhus – Real-Time RT-PCR Detection of Scrub Typhus Total Nucleic Acid Assay with High Sensitivity and Specificityexternal icon
- Syphilis – Immunoassays and Methods to Diagnose Syphilis by Immobilizing a Lipoidal Antigen on a Solid Supportexternal icon
- Water Pathogens — Monitoring Public Water Supply for a Variety of Pathogensexternal icon
Drug Delivery
- Intranasal Dry Powder Inhaler for Improved Delivery of Vaccines and Therapeuticsexternal icon
- Intranasal Nebulizer with Disposable Drug Cartridge for Improved Delivery of Vaccines and Therapeuticsexternal icon
Ergonomic and Musculoskeletal Injury Prevention
- Occupational Health: Wearable Kneel-Sit Support Device for Manual Labor and Heavy Industry Applicationsexternal icon
- Occupational Safety: Portable Exposure Assessment System for Prevention of Musculoskeletal Injuryexternal icon
Fall Prevention
Fishing and Maritime Safety
- Cable-line Safety System: Electro/hydraulic Emergency Stop Device for a Winch, Drum or Capstanexternal icon
- Emergency Maritime Battery Chargerexternal icon
- Swing-Away Winch Cathead Guardexternal icon
Hazard Assessment
- Local Positioning System for Position-Time-Condition Correlation, Data-logging and Analysisexternal icon
- Warning System for Mobile Machinery Hazardous Zonesexternal icon
Healthcare Associated Infection Prevention
Hearing Safety
Lead Detection and Removal
- Handwipe Disclosing Method for Detecting the Presence of Leadexternal icon
- Wipes and Methods for Removal of Lead and Other Metal Contamination from Surfacesexternal icon
Mining Safety
Mosquito and Pest Control Devices
- A Bias-free Sampling and Collection Trap for Resting Mosquitoesexternal icon
- CDC Mosquito Trap for Control and Surveillance of Mosquitoes Including Carriers of Zika & Other Virusesexternal icon
- Entangling/Entrapping Synthetic Setae for Control of Insects and Other Pestsexternal icon
Pulmonary Assessment and Respirator Technology
- Device to Measure Muscle Contractile-Relaxant and Epithelial Bioelectric Responses of Perfused, Intact Tracheal…external icon
- Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Functionexternal icon
- Methods and Apparatus for Computer-Aided Cough Sound Analysisexternal icon
- Ultrasonic in situ Respirator Seal-Leakage Detection with Real-time Feedback Capabilitiesexternal icon
Software, Algorithms, and Imaging
- Automated Microscopic Image Acquisition, Compositing and Display Software Developed for Applied Microscopy/Cytology…external icon
- Method for Finding Usable Portion of Sigmoid Curve (the Taylor Method), Improved Assay Readouts, and Enhanced…external icon
- Personalized Cancer Evaluation (PERCEVAL) Method and Softwareexternal icon
- Virus Microneutralization Assay Data Analysis for Vaccine Development, Enhancement and Efficacy Improvementexternal icon
Telemedicine
Therapeutic and Research Use
Water Monitoring
Aerosol Exposure
- Computer Controlled Aerosol Generator with Multi-Walled Carbon Nanotube Inhalation Testing Capabilitiesexternal icon
- Non-radioactive, Miniature Bipolar Aerosol Particle Charger for Personal, Portable Instrumentationexternal icon
Air Quality and Aerosol Analysis
- Diisocyanate Specific Monoclonal Antibodies for Occupational and Environmental Monitoring of Polyurethane Production Exposure-related Asthma and Allergy and Clinical Diagnosisexternal icon
- Focused Electrostatic Collection of Aerosol Particles for Chemical Analysis by Spectroscopic Techniquesexternal icon
- Methods for Near Real-time Chemical Analysis of Aerosols using Microwave-induced Plasma Spectroscopyexternal icon
Chemotherapy Contaminant Detection
Counterfeit Drug Detection
- A Simple Colorimetric Assay for Anti-malarial Drugs Quality Assurance and Rapid, On-site Counterfeit Detectionexternal icon
- Portable Laser-Operated Counterfeit Drug Identifier (CoDI) for Tabletsexternal icon
Diagnostics
- Anthrax
- Assay for Early Diagnosis of Anthrax Using Monoclonal Antibodies Against Anthrax Toxinexternal icon
- Exposure and Activity Detection Assays for Anthrax Lethal Factor and Lethal Toxinexternal icon
- Stable, Early-stage Biomarker for Diagnosis of Bacillus anthracis Infection and Anthrax Vaccine Developmentexternal icon
- Antibiotic Resistance – Real-Time PCR Assay for Detection of Carbapenem Antibiotic Resistance Genes of the IMP-type external icon
- Antifungal Resistance – DNA Probes to Rapidly Screen Candida glabrata Isolates for Echinocandin Resistance to Antifungal Treatmentexternal icon
- Bocavirus – Real-time PCR Assays for Human Bocavirus Detection and Diagnosisexternal icon
- Botulism – Improved Botulism, Botulinum Neurotoxin Type-E Diagnosticsexternal icon
- Clostridium difficile (C. difficile), Bordetella pertussis, and more — Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile,…external icon
- Dengue Virus
- Dengue/West Nile Viruses – High-Titer, Fast-Growth Chimeric Dengue/West Nile Viruses for Vaccine and Diagnostics Developmentexternal icon
- Enterovirus
- Flavivirus
- Fungal Pathogens
- Detection and Differentiation of Pathogenic Fungi in Clinical Samples Using a Multi-Analyte Profiling Systemexternal icon
- Nucleic Acid Assays for the Detection and Discrimination of Aspergillus Fungi Species within Biological Samplesexternal icon
- Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samplesexternal icon
- Nucleic Acid-based Compositions and Methods for the Detection of Pathogenic Candida or Aspergillus Fungi Speciesexternal icon
- Nucleic Acid-based Compositions and Methods for the Species-Specific Detection of Pathogenic Candida Fungiexternal icon
- Nucleic Acid-based Differentiation and Identification of Medically Important Fungiexternal icon
- Species-specific Nucleic Acid Detection Assay for Fungiexternal icon
- Hepatitis C – Novel Enzyme-Based Immunoassay for Simultaneous Detection of Hepatitis C Virus Antigen and Antibody in Human Serum or Plasmaexternal icon
- Hepatitis E – Immunogenic Hepatitis E Virus Polypeptides for Vaccine and Diagnostics Developmentexternal icon
- HIVDrug Resistant HIV – Rapid Detection of Antiretroviral(s) Drug-Resistant HIV-1 within Clinical Samplesexternal icon
- HIV – Composition and Methods for Rapid Detection of HIV by Loop-mediated Isothermal Amplificationexternal icon
- HIV-1 – A Device for Simultaneous and Rapid Diagnosis and Detection of Recent and Long Term HIV-1 Infectionexternal icon
- HIV-1 – HIV-1 BED: A Simple Serological Assay for Detecting Recent Infection and Estimating Incidence of Multiple, Worldwide HIV-1 Subtypesexternal icon
- HIV-1 – Monoclonal Antibodies to the HIV-1 Core Protein p24external icon
- HIV-1 – Simple and Rapid Assay to Detect Acute Subtype B and Group M HIV-1 Infectionsexternal icon
- HIV-1 and HIV-2 – Multivalent, Multiple-Antigenic-Peptides for Serological Detection of HIV-1 Groups -M, -N, -O, and HIV-2external icon
- HIV-1 and Retroviruses – Detection of Retroviruses and HIV-1 Groups -M and -O Discrimination within Clinical Serum Samplesexternal icon
- HIV-1 and Simian Immunodeficiency Virus (SIV) – Molecular Detection and Viral-Load Quantification for HIV-1 Groups M, N and O, and Simian Immunodeficiency Virus-cpz (SIVcpz)external icon
- HIV-2 – On-site in vitro Diagnostic: Real-time Loop-Mediated Isothermal Amplification Detection of HIV-2 Groups A and Bexternal icon
- HIV and SIV Type Retroviruses – Multiple Antigenic Peptide Assays for Detection of HIV and SIV Type Retrovirusesexternal icon
- HIV Drug Adherence – Monoclonal Antibody to Detect the Antiretroviral Drug Emtricitabine – for HIV Drug Adherence Monitoring external icon
- Influenza
- Human Influenza Virus Real-time RT-PCR: Detection and Discrimination of Influenza A (H3N2) Variant from Seasonal Influenza A (H3N2) Viruses, Including H3v and Seasonal H3 Assaysexternal icon
- Influenza A Virus Detection and Subtyping Directly from Animal Swabs and Environmental Samplesexternal icon
- MDCK-based Reporter System for Detection of Influenza Viruses, Antiviral Drug Screening, and Analysis of Neutralizing Antibodiesexternal icon
- Real-time RT-PCR assay for Detection of Live Attenuated Influenza Vaccine for A and B Viruses external icon
- The CDC 2009 Influenza A H1N1 (Flu) Pandemic Real-time RT-PCR Panel including Pandemic Influenza A and Pandemic H1 Assaysexternal icon
- Lyme Disease — Compositions and Methods for Improved Lyme Disease Diagnosisexternal icon
- Malaria – Simple, Field-Usable Fluorescence-Based Isothermal LAMP Assay for the On-Site Diagnosis of Malariaexternal icon
- Mass Spectrometry and Biomarker Analysis – Use of Detector Response Curves to Optimize Settings for Mass Spectrometryexternal icon
- Phlebovirus – Diagnostics, Vaccines, and Delivery-Vehicles Related to Novel Phlebovirusexternal icon
- Pneumonia
- Antigen, Encoding Gene, Related Monoclonal Antibody and Hybridoma Clones for Streptococcus pneumoniae Serological Diagnosticsexternal icon
- Encapsulated Streptococcus Compositions and Methods for Pneumococcal Vaccine, Probiotic, and Diagnostic Assay Developmentexternal icon
- Immunoassay for the Simultaneous Detection of Functional Antibodies against Multiple Serotypes of Streptococcus pneumoniae and Other Bacteria Typesexternal icon
- Novel Peptide of Streptococcus pneumoniae Surface Adhesion A (PsaA) Protein Associated with Adherence and Uses Thereof – for Vaccine Candidate, Therapeutic and Diagnostic Developmentexternal icon
- Real-time PCR Detection of Streptococcus pneumoniae with High Sensitivity and Specificityexternal icon
- Simple and Rapid Loop-Mediated Isothermal Amplification (LAMP)-based Assay for Mycoplasma pneumoniae Detectionexternal icon
- Retrovirus (also above)
- Rickettsia – Real-Time RT-PCR Detection of Rickettsia species — PanR6/Total Nucleic Acid Assay with High Sensitivity and Specificityexternal icon
- Rift Valley Fever – Real-time RT-PCR Assay for the Detection of Rift Valley Fever Virus in Humans and Livestockexternal icon
- Rotavirus – Controlled Expression and Assembly of Human Group-C Rotavirus-like Particles for Creation of Rotavirus Diagnostic Assays and Improved Vaccine Formulationsexternal icon
- Scrub Typhus – Real-Time RT-PCR Detection of Scrub Typhus Total Nucleic Acid Assay with High Sensitivity and Specificityexternal icon
- Syphilis
- Cardiolipin Modification for Immunoassay Detection of Syphilisexternal icon
- Diagnostic Assay with Modified Cardiolipin for Detecting Active Syphilis Infectionsexternal icon
- Immunoassays and Methods to Diagnose Syphilis by Immobilizing a Lipoidal Antigen on a Solid Supportexternal icon
- Methods for Detecting Syphilis Using Synthetic Antigensexternal icon
- Tuberculosis – Diagnostic Antigens for the Identification of Latent Tuberculosis Infectionexternal icon
- Water Pathogens – Monitoring Public Water Supply for a Variety of Pathogensexternal icon
- Zika Virus
- Chimeric Dengue/Zika Viruses for Live-Attenuated Zika Vaccine Development external icon(and Diagnostics)
- Monoclonal Antibodies that Bind Zika Virus Envelope Protein for Zika Diagnostics and Researchexternal icon
- Rapid Colorimetric Detection of Zika Virus from Serum and Urine Specimens by RT-LAMP (Reverse Transcription Loop-Mediated Isothermal Amplification).external icon
- West Nile/Zika Virus Chimeras for Inactivated Zika Vaccine and Diagnostic Assay Development external icon
- Zika Virus NS1 Protein Monoclonal Antibodies for Research, Development, and Novel Diagnosticsexternal icon
Diagnostics/Laboratory Other
- Fluorescent Primer(s) Creation for Nucleic Acid Detection and Amplificationexternal icon
- Generation of Artificial Mutation Controls for Diagnostic Testingexternal icon
- Method to remove human DNA when sequencing for parasite infectionexternal icon
- Method to Remove Mycoplasma Contamination from Virus Stocks external icon
- Methods for the Simultaneous Detection of Multiple Analytesexternal icon
- Methods of Retaining Methylation Pattern Information in Globally Amplified DNAexternal icon
- Multiplexed Immunoassay for Rapid Serological Diagnosis of a Specific Viral Infection in Clinical Samplesexternal icon
- Novel UNEX Buffer and Disk for Safe Storage and Transport at Ambient Temperatures of Clinical Specimens for Molecular Testing of Pathogensexternal icon
- Nucleic Acid Amplification Technique for Rapid Diagnostic Analysisexternal icon
- One-step random amplification method to detect extremely low input nucleic acids for virome, microbiome, and metagenomics in clinical and biological specimensexternal icon
- Photoinduced Electron Transfer Fluorescent Primer for Nucleic Acid Amplificationexternal icon
- Rapid Method for the Detection of Antigen-Specific Antibodies in Any Speciesexternal icon
Drug Delivery
Ergonomic and Musculoskeletal Injury Prevention
Fall Prevention
Fishing and Maritime Safety
Hazard Assessment
Healthcare Associated Infection (HAI) Prevention
Hearing Safety
Lead Detection and Removal
- Lead Detection Wipes for Potentially Contaminated Surfacesexternal icon
- Lead Removal Wipes – *please contact TTO@cdc.gov for more information.
Mining Safety
Mosquito and Pest Control Devices
- A Bias-free Sampling and Collection Trap for Resting Mosquitoesexternal icon
- CDC Mosquito Trap for Control and Surveillance of Mosquitoes Including Carriers of Zika & Other Virusesexternal icon
- Entangling/Entrapping Synthetic Setae for Control of Insects and Other Pestsexternal icon
Pulmonary Assessment and Respirator Technology
- Device to Measure Muscle Contractile-Relaxant and Epithelial Bioelectric Responses of Perfused, Intact Tracheal…external icon
- Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Functionexternal icon
- Methods and Apparatus for Computer-Aided Cough Sound Analysisexternal icon
- Ultrasonic in situ Respirator Seal-Leakage Detection with Real-time Feedback Capabilitiesexternal icon
Software, Algorithms, and Imaging
- Automated Microscopic Image Acquisition, Compositing and Display Software Developed for Applied Microscopy/Cytology…external icon
- Method for Finding Usable Portion of Sigmoid Curve (the Taylor Method), Improved Assay Readouts, and Enhanced…external icon
Telemedicine
Vaccines and/or Therapeutics Research
- Flavivirus –
- Discrete Cross-Reactive Epitopes for Flavivirus Serological Diagnostics and Vaccinesexternal icon
- Polypeptides and Methods for Enhancing and Balancing Monovalent or Multivalent Flavivirus Vaccinesexternal icon
- Recombinant Nucleic-Acid Based Flavivirus Nucleic Acids for Development of Vaccines and/or Sero-diagnosticsexternal icon
- Infections By Intracellular Pathogens (e.g., viruses, bacteria, and parasites) – Vaccine Attenuation via Deoptimization of Synonymous Codonsexternal icon
- lnfluenza – Improved Protein Quantification Process and Vaccine Quality Control Productionexternal icon
- Pathogen-associated Inflammatory Response – Methods for Amelioration and Treatment of Pathogen-associated Inflammatory Responseexternal icon
- Phlebovirus – Diagnostics, Vaccines, and Delivery-Vehicles Related to Novel Phlebovirusexternal icon
- Pneumonia
- Encapsulated Streptococcus Compositions and Methods for Pneumococcal Vaccine, Probiotic, and Diagnostic Assay Developmentexternal icon
- Multi-Antigenic Peptide(s) Vaccine and Immunogen for Conferring Streptococcus pneumoniae Immunityexternal icon
- Novel Peptide of Streptococcus pneumoniae Surface Adhesion A (PsaA) Protein Associated with Adherence and Uses Thereof – for Vaccine Candidate, Therapeutic and Diagnostic Developmentexternal icon
- Rabies – Antibodies for Rabies Post-exposure Prophylaxis or Antiviral Therapy of Clinical Rabiesexternal icon
- Respiratory Syncytial Virus (RSV) – Respiratory Syncytial Virus (RSV) Immunogens for Vaccine and Therapeutics Development external icon
- Rift Valley Fever
- Rotavirus
- Therapeutics/Protein Research – Therapeutic, Bifunctional Janus Microparticles with Spatially Segregated Surface Proteins and Methods of Production…external icon
- Tuberculosis
- West Nile Virus – High-Titer, Fast-Growth Chimeric Dengue/West Nile Viruses for Vaccine and Diagnostics Developmentexternal icon
- Zika – Chimeric Dengue/Zika Viruses for Live-Attenuated Zika Vaccine Development external icon
Water Monitoring
![streptococcus. streptococcus.](https://webarchive.library.unt.edu/web/20201221164815im_/https://www.cdc.gov/os/technology/techtransfer/images/streptococcus-small.jpg)
CDC PHIL photo, Dan Higgins.
- CDC has discovered encapsulated strains of commensal Streptococcus species, mitis, S. oralis, and S. infantis, which have capsules that are identical to pneumococcal capsules. From this, researchers developed compositions and methods from the species’ biosynthetic capsular genes.
- The technology shows promise for protecting people against pneumococcal disease, either by using these strains as vaccines or probiotics, or through development of diagnostic assays.
- Initial results show cross-protection against eight pneumoniae serotypes, including serotype 1, a leading cause of invasive pneumococcal disease globally outside of the US.
- Initial concept studies have been performed in animal models.
![Backflushing The photo shows a CDC researcher backflushing an ultrafiltered water sample. Photo credit: CDC Photo Services.](https://webarchive.library.unt.edu/web/20201221164815im_/https://www.cdc.gov/os/technology/techtransfer/images/Backflushing-small.jpg)
Photo credit: CDC Photo Services.
Monitoring Public Water Supply for a Variety of Pathogensexternal icon
- CDC have combined two techniques, ultrafiltration (UF) and insulator-based dielectrophoresis (iDEP) in series, to achieve significant concentration of microbes and pathogens for analysis
- UF can concentrate a water sample ≥200X, depending on turbidity; if a secondary concentration step is applied, then a ≥25,000X can be achieved
- This technology may be used for monitoring of municipal, commercial, public, and individual water supplies for drinking water quality as well as additional applications
![Counterfeit_Drugs Photo of Counterfeit Drugs](https://webarchive.library.unt.edu/web/20201221164815im_/https://www.cdc.gov/os/technology/techtransfer/images/Counterfeit_Drugs.jpg)
Photo of Counterfeit Drugs
Portable Laser-Operated Counterfeit Drug Identifier (CoDI) for Tabletsexternal icon
- Portable Laser-Operated Counterfeit Drug Identifier (CoDI) for Tabletsexternal icon
- CDC researchers developed a portable (handheld), battery-operated, and relatively inexpensive device that non-trained personnel can use quickly to evaluate a particular branded tablet for authenticity.
- The instrument can detect counterfeit, degraded, and expired drugs in tablet formation
- CDC researchers successfully tested the CoDI prototype in Ghana on a project to detect falsified, degraded, and expired ingredients in antimalarial tablets. Field trials to test additional drug samples are underway.
![mosqitoes-2 photo depicts and Aedes species mosquito](https://webarchive.library.unt.edu/web/20201221164815im_/https://www.cdc.gov/os/technology/techtransfer/images/mosqitoes-2-small.jpg)
Photo credit James Gathany, CDC
- CDC researchers developed a diagnostic assay for the detection and
differentiation of Zika, chikungunya and dengue viruses - Currently, there is no multiplex PCR assay on the market that can detect and differentiate Zika, dengue and chikungunya in one test
- There is no FDA-approved chikungunya test on the market and current Zika and dengue tests must be run separately
![mosqitoes Mosquito](https://webarchive.library.unt.edu/web/20201221164815im_/https://www.cdc.gov/os/technology/techtransfer/images/mosqitoes-small.jpg)
Photo depicts an Aedes species mosquito. Photo credit James Gathany, CDC.
- CDC researchers developed the autocidal gravid ovitrap (AGO) device that targets older female mosquitoes looking for a place to lay eggs
- CDC and the Puerto Rico Department of Health are implementing large-scale installation of AGO traps throughout several communities to reduce mosquito populations and the viruses they spread after successful field trials
- Traps can be used for surveillance and control of Aedes aegypti and Ae. albopictus mosquitoes
Hemophilia is an inherited bleeding disorder caused by genetic mutations resulting in deficiencies in coagulation factors necessary for blood clotting. The two forms of hemophilia, hemophilia A and hemophilia B, collectively affect an estimated 400,000 people worldwide. In addition, about 1-in-1,000,000 people who do not have hemophilia A or B will develop factor inhibitors, leading to acquired hemophilia. The primary form of treatment for any hemophilia is infusion therapy to replace the missing or dysfunctional coagulation factor. A subset of patients develop an immune response to the infusion product, which leads to the production of neutralizing antibodies called inhibitors. Inhibitors bind to and inhibit the function of infused factor, which nullifies any treatment benefit, including the restoration of clot formation. Development of inhibitors makes it more difficult to stop a bleeding episode and markedly increases hospitalizations, patient morbidity, and cost of treatment. Early identification of patients who develop inhibitors is crucial for optimizing patient management strategies.
CDC scientists have developed a fluorescence immunoassay (FLI) to directly detect immunoglobulin G (IgG) subclasses of inhibitors in patient samples. The FLI method offers greater sensitivity than currently available methods and requires significantly smaller (approximately 50 times less) patient plasma volumes for detection. Additionally, the FLI method is not affected by the presence of bypassing agents used in hemophilia treatment or by non-specific inhibitors of coagulation; it is more amenable to uniform inter-laboratory positive thresholds, and since it is IgG subclass-specific, it is capable of identifying antibodies known to cause clinically relevant inhibition.
- Diagnostic test kit for local clinical laboratories and hemophilia treatment centers
- Latex immuno-agglutination and luminescent oxygen channeling assays to run on automated coagulation analyzers
- Enzyme-linked immunosorbent assay
- Pre-screening for congenital and acquired hemophilia patients prior to factor therapy administration
- Detection of specific antibodies in acquired hemophilia
- Distinguishing factor inhibitors from lupus anticoagulants
- Inhibitor surveillance programs
- Research tool to perform quality assurance/quality control on the inhibitor detection methods that are currently used in clinical laboratories and/or to serve as a confirmatory test for specimens that have results approaching positive thresholds using current methodologies
- High sensitivity and specificity
- Direct detection of coagulation factor inhibitors with IgG subclass specificity
- Easy to interpret results
- Smaller sample volume inputs required
- More amenable to uniform inter-laboratory positive thresholds
- Fewer false positives or false negatives versus currently available methods
- Assay not affected by bypassing agents or next generation factor treatment products with extended half-lives
Intellectual Property
HHS Reference No. E-083-2018/0.
Inventors: Brian Boylan (CDC) and Connie Miller (CDC)
Market without protection.
CDC Reference No. I-004-18.
*Contact CDC TTO at 404.639.1330 or TTO@cdc.gov for more information.