Preventing New HIV Infections
The listed guidelines and related implementation resources provide guidance about prevention strategies and services that can prevent or diagnose new HIV infections and link individuals at risk to relevant prevention, medical and social services.
Guidelines
Current Guidelines | Some sections may be out-of-date. | Out of date/Superseded |
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Updates U.S. Public Health Service recommendations for the management of health-care personnel (HCP) who have occupational exposure to blood and/or other body fluids that might contain HIV. Although the principles of exposure management remain unchanged, recommended HIV postexposure prophylaxis (PEP) regimens and the duration of HIV follow-up testing for exposed personnel have been updated.
Title and Description | Publication Year | Status |
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Preexposure Prophylaxis (PrEP)NoticeFDA has approved daily oral antiretroviral preexposure prophylaxis (PrEP) with Truvada for adolescents and adults who weigh at least 35 kilograms (77 pounds). On May 15, 2018, the Food and Drug Administration approved an indication for Truvada for preexposure prophylaxis (PrEP) in adults and adolescents who weigh at least 35 kg (77 lb). The indications for PrEP, initial and follow-up prescribing and laboratory testing recommendations are the same for adolescents and adults. This change for adolescent use will be incorporated into the next update to the PrEP guidelines. |
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Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: a Clinical Practice Guideline pdf icon[PDF – 2 MB] This updates the review of scientific evidence on the safety and efficacy of daily oral antiretroviral HIV preexposure prophylaxis (PrEP). The update includes additional guidance for recommended STD screening, hepatitis C testing, and HIV testing for patients being prescribed PrEP. |
2017 | ![]() |
Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: Clinical Providers Supplement pdf icon[PDF – 2 MB] This update includes three new sections that provide an HIV risk index for assessing persons who inject drugs for PrEP indications, clinical guidance for transitioning people to PrEP after a course of nonoccupational postexposure prophylaxis (PEP), and clinical guidance for transitioning people to treatment regimens if they acquire HIV infection while being prescribed PrEP. In addition, it provides updates to the provider information for counseling patients about PrEP use during conception, pregnancy and breastfeeding. |
2017 | ![]() |
Non-occupational Post-exposure Prophylaxis |
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New (September 17, 2018)Update (May 23, 2018)Interim Statement Regarding Potential Fetal Harm from Exposure to Dolutegravir – Implications for HIV Post-exposure Prophylaxis (PEP). Please see attached PDF pdf icon[PDF – 104 KB]. |
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Updated guidelines for antiretroviral postexposure prophylaxis after sexual, injection drug use, or other nonoccupational exposure to HIV—United States, 2016 Updates and expands the 2005 U.S. Department of Health and Human Services recommendations for clinical care providers regarding nonoccupational postexposure prophylaxis (nPEP) for exposure to human immunodeficiency virus (HIV) outside the health care setting for persons in the United States. The update includes pediatric dosing information. |
2016 | ![]() |
Recommendations for Postexposure Interventions to Prevent Infection with Hepatitis B Virus, Hepatitis C Virus, or Human Immunodeficiency Virus, and Tetanus in Persons Wounded During Bombings and Other Mass–Casualty Events—United States Outlines and adapts existing general recommendations on the use of immunization and postexposure prophylaxis for tetanus and for occupational and nonoccupational exposures to bloodborne pathogens to the specific situation of a mass-casualty event.Note: Information about the use of PEP with HIV has been updated in newer guidelines |
2008 | ![]() |
Occupational Post-exposure Prophylaxis |
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Prevention with Partners of Persons with HIV |
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Recommendations for Partner Services Programs for HIV Infection, Syphilis, Gonorrhea, and Chlamydial Infection This report provides updated, integrated recommendations for services provided to partners of persons with human immunodeficiency virus (HIV) infection and three other sexually transmitted diseases (STDs) (i.e., syphilis, gonorrhea, and chlamydial infection)Note: Some recommendations and supporting evidence have been updated in the Recommendations for HIV Prevention with Adults and Adolescents with HIV. Implementation Resources: |
2008 | ![]() |
Screening for STDS |
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HIV Infection: Detection, Counseling, and Referral Provides updated recommendations for the screening and treatment of persons who have or are at risk for sexually transmitted diseases (STDs) including HIV |
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Contraceptive Use |
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The United States Medical Eligibility Criteria for Contraceptive Use, 2016 (US MEC) The information in this report updates the 2010 U.S. MEC (CDC. U.S. Medical Eligibility Criteria for Contraceptive Use, 2010. MMWR 2010:59 [No. RR-4]) and includes recommendations for using specific contraceptive methods by women and men who have certain characteristics or medical conditions. Notable updates include the addition of recommendations for women with sexually transmitted diseases, human immunodeficiency virus, or who are using antiretroviral therapy. |
2016 | ![]() |
Other |
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Recommendations to Improve Preconception Health and Health Care—United States: a Report Of The CDC/ATSDR Preconception Care Work Group and the Select Panel on Preconception Care Provides recommendations to improve both preconception health and care. The goal of these recommendations is to improve the health of women and couples, before conception of a first or subsequent pregnancy.Note: Some of the recommendations have been updated/adapted in the Recommendations for HIV Prevention with Adults and Adolescents with HIV. |
2006 | ![]() |
Implementation Guidance
Title and Description | Publication
Year |
Status |
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Quick Guide: Recommendations For Partner Services Programs For HIV Infection, Syphilis, Gonorrhea, And Chlamydial Infectionpdf iconIntended to serve as a quick reference resource and as such, lists only the recommendations and data security guidelines included in the MMWR
Note: Some of the recommendations on partner services have been updated in the Recommendations for HIV Prevention with Adults and Adolescents with HIV |
2010 | ![]() |
Partner Services Evaluation Field Guide (PSEFG)pdf iconProvides organizations, specifically health department personnel at the state and local levels, with step-by-step instructions to assist in the development and implementation of monitoring and evaluation activities for partner services programs. | 2010 | ![]() |