General areas of research interest of the principal investigators in DIR are listed below. The investigators' names link to their NIAID Web pages, which provide research descriptions, links to publications, and contact information.
View list of lab abbreviations
| Name | Areas of Expertise |
|---|---|
| Barry III, Clifton E., Ph.D. Senior Investigator, LCIM |
Mycobacterium tuberculosis, TB drug development, MDR-TB, XDR-TB |
| Belkaid, Yasmine, Ph.D. Investigator, LPD |
Tregs, regulatory T cells, parasitic diseases, Foxp3 |
| Bennett, John E., M.D. Senior Investigator, LCIM |
Candida, fungal diseases, drug resistance, azole, drug transport |
| Bennink, Jack R., Ph.D. Senior Investigator, LVD |
Viral immunology, antigen presentation, vaccinia, influenza, immunodominance |
| Best, Sonja M., Ph.D. Senior Investigator, LV |
Innate immunity, viral infection, flaviviruses, viral protease, dendritic cells, DCs |
| Bloom, Marshall, M.D. Senior Investigator, LPVD |
Tickborne encephalitis virus, interferon, JAK-STAT signal transduction |
| Bolland, Silvia, Ph.D. Investigator, LIG |
Autoimmunity, lupus, SLE, glomerulonephritis, FCR |
| Bosio, Catharine (Katy), Ph.D. Senior Investigator, LB |
Fransiella tularensis, tularemia, vaccines, anti-inflammatory lipid, innate immunity, antigen presentation, APC, dendritic cells, DCs, macrophage |
| Bouamr, Fadila, Ph.D. Investigator, LMM |
Retroviral assembly, HIV-1 Gag, HTLV-I Gag, virus-host interactions |
| Caughey, Byron, Ph.D. Senior Investigator, LPVD |
Transmissible spongiform encephalopathies, prion, chronic wasting disease, scrapie, Creutzfeldt-Jakob disease, BSE |
| Chanock, Robert, M.D. Senior Investigator, LID |
Vaccine development, respiratory viruses |
| Chesebro, Bruce, M.D. Laboratory Chief, LPVD |
Transmissible spongiform encephalopathies, prion protein retroviral brain diseases |
| Cohen, Jeffrey I., M.D. Senior Investigator, LCIM |
Chickenpox, shingles, zoster, varicella, herpesvirus, EBV, HSV, VZV |
| Ursula Buchholz, Ph.D. Investigator, LID |
Human metapneumovirus, paramyxovirus, live attenuated vaccine, pediatric infectious disease, RSV, parainfluenza |
| Connors, Mark, M.D. Senior Clin. Investigator, LIR |
HIV/AIDS, long-term non-progressors, HIV immunity, cytotoxic T cell, HIV vaccine |
| Davey, Richard T., M.D. Senior Clin. Investigator, LIR |
HIV/AIDS clinical research, HAART, antiretroviral therapy, immune-based therapy, IL-2, interrupted therapy |
| DeLeo, Frank R., Ph.D. Senior Investigator, LHBP |
Phagocytosis, neutrophil, Staphylococcus aureus,Streptococcus pyogenes, inflammation, innate immunity |
| Desai, Sanjay, M.D., Ph.D. Investigator, LMVR |
Malaria parasite nutrient acquisition, ion transport, electrophysiology, Plasmodium falciparum |
| De Wit, Emmie, Ph.D. Investigator, LV |
Pathogenesis, therapeutics, emerging viruses |
| Druey, Kirk M., M.D. Senior Investigator, LAD |
Asthma, lung, airway smooth muscle, G proteins, RGS proteins |
| Ehrenfeld, Elvera, Ph.D. Senior Investigator, LID |
Poliovirus, rhinovirus, Coxsackie virus, RNA replication, picornavirus |
| Emerson, Suzanne, Ph.D. Senior Investigator, LID |
Hepatitis molecular biology, hepatitis E, hepatitis C, infectious cDNA clones, monoclonal antibodies |
| Farber, Joshua, M.D. Senior Investigator, LMI |
Chemokines, receptors, NK cells, dendritic cells, leukocyte trafficking |
| Farci, Patrizia, M.D. Senior Investigator, LID |
Hepatitis C |
| Fauci, Anthony S., M.D. Laboratory Chief, LIR |
HIV immunopathogenesis, AIDS, HIV latency |
| Feldmann, Heinz, M.D., Ph.D. Senior Investigator, LV |
Viral vector platforms, vaccines, emerging infectious diseases, biodefense, re-emerging viral pathogens |
| Fowlkes, B.J., Ph.D. Senior Investigator, LI |
T-cell development, thymus, thymocytes, T cells, TCR, Notch, presenilin |
| Gallin, John I., M.D. Senior Investigator, LCIM |
Granulomatous disorders, inherited mmunodeficiency, inflammation, chronic granulomatous disease |
| Garboczi, David, Ph.D. Investigator, LIG |
T-cell receptors, protein crystallography, malaria, receptor-ligands, parasite surface proteins, X-ray crystallography |
| Germain, Ronald N., M.D., Ph.D. Deputy Chief, LI |
T-cell receptor, MHC molecule, signal transduction, lymphocyte homeostasis, computer modeling, imaging |
| Gherardini, Frank, Ph.D. Senior Investigator, LZP |
Burkholderia mallei, B. pseudomallei, borrelia, glanders, melioidosis |
| Grigg, Michael, Ph.D. Investigator, LPD |
Toxoplasma gondii, toxoplasmosis |
| Hackstadt, T. W., Ph.D. Senior Investigator, LICP |
Rickettsia, Rocky Mountain spotted fever, Chlamydia trachomatis, trachoma, STI |
| Haigh, Cathryn L., Ph.D. Investigator, LPVD |
Prion, BSE, Creutzfeldt-Jakob disease, CJD, protein-folding diseases, retroviral pathogenesis, chronic wasting disease, CWD |
| Hasenkrug, Kim, Ph.D. Investigator, LPVD |
Retroviral immunology, persistent virus, Friend virus, erythroleukemia, regulatory T cells, |
| Heinzen, Robert, Ph.D. Investigator, LICP |
Coxiella burnetii, Q fever, endocarditis, cell biology, intracellular parasitism, vesicle trafficking |
| Hinnebusch, Joe, Ph.D. Senior Investigator, LZP |
Yersinia pestis, plague, arthropod-borne transmission,Xenopsylla cheopis, fleas |
| Hirsch, Vanessa M., D.V.M., S.D. Senior Investigator, LMM |
AIDS vaccine development, SIV phylogeny |
| Holland, Steven, M.D. Laboratory Chief, LCIM |
Mycobacteria, NTM, chronic granulomatous disease, Job's syndrome, immune disorders |
| Inman, John K., Ph.D. Senior Investigator, LI |
|
| Jackson, Sharon, M.D. Investigator, LCIM |
Hematopoietic progenitor, dendritic cell, granulocyte, macrophage, APC, inflammation, apoptosis |
| Jain, Ashish, M.D. Investigator, LCIM |
Primary immune deficiency, NEMO |
| Jeang, Kuan Teh, M.D., Ph.D. Senior Investigator, LMM |
AIDS, adult T-cell leukemia, cancer, HIV-1, HTLV-I, Tat, Tax, retrovirus |
| Jin, Tian, Ph.D. Investigator, LIG |
Live cell imaging, fluorescence resonance energy transfer, quantitative modeling, HIV entry receptors |
| Keane-Myers, Andrea, Ph.D. Investigator, LAD |
Allergy, allergic asthma |
| Kehrl, John H., M.D. Senior Investigator, LIR |
RGS, G-protein, chemokine, chemotaxis, lymphocytes |
| Kelsall, Brian, M.D. Senior Investigator, LMI |
IL-12, CR3, complement, dendritic cell, Peyer's patch, mucosal immunity, chemokine, autoimmunity |
| Kozak, Christine, Ph.D. Senior Investigator, LMM |
Leukemia viruses, mouse genomics, retroviruses, mouse leukemia virus, MuLV |
| Kristie, Thomas, Ph.D. Senior Investigator, LVD |
Herpes, HSV, transcription, gene regulation, latency |
| Kwon-Chung, Kyung, Ph.D. Senior Investigator, LCIM |
Cryptococcus, aspergillus, fungi, fungal diseases |
| Lai, Ching-Juh, Ph.D. Senior Investigator, LID |
Dengue, flaviviurses, antibody repertoire cloning, chimpanzee Fabs, humanized monoclonal antibodies |
| Lane, H. Clifford, M.D. Senior Investigator, LIR |
Biodefense, anthrax, smallpox, SARS, influenza, AIDS |
| Lenardo, Michael, M.D. Senior Investigator, LI |
T regulatory cells, Tregs, suppression, lymphocyte, apoptosis, receptor, caspase-8, NF-κB, Bcl-2 |
| Leppla, Stephen, Ph.D. Senior Investigator, LBD |
Anthrax, toxin, protease, mutagenesis, Bacillus anthracis |
| Leto, Thomas, Ph.D. Senior Investigator, LCIM |
NADPH oxidase, Nox, phagocyte biochemistry, chronic granulomatous disease, innate immunity, cystic fibrosis |
| Lobanenkov, Victor, Ph.D. Senior Investigator, LIP |
Cancer, BORIS, CTCF, DNA methylation |
| Long, Eric O., Ph.D. Senior Investigator, LIG |
NK cells, cell adhesion, cytotoxicity, degranulation, HLA-C, HLA, immune synapse, inhibitory receptor |
| McBride, Alison, Ph.D. Senior Investigator, LVD |
Papillomaviruses, HPV, keratinocyte biology |
| McCutchan, Thomas, Ph.D. Senior Investigator, LMVR |
Malaria, antibiotics, thiopeptides, protein synthesis regulation, plasmodium development |
| Mage, Rose G., Ph.D. Senior Investigator, LI |
Autoimmune diseases, rabbit, splenic germinal centers, rabbit appendix |
| Malech, Harry L., M.D. Laboratory Chief, LCIM |
Gene therapy, chronic granulomatous disease, X-linked SCID, stem cells, WHIM syndrome, lentiviral vector |
| Margulies, David H., M.D., Ph.D. Senior Investigator, LI |
MHC, T cell receptors, NK receptors, transgenic mice, autoimmunity, autoimmune gastritis |
| Martin, Malcolm A., M.D. Laboratory Chief, LMM |
HIV pathogenesis, HIV animal models, HIV vaccines, neutralizing antibody, SIV/HIV chimeric viruses, SHIV |
| Marzi, Andrea, Ph.D. Investigator, LV |
Pathogenesis, vaccines, immune response |
| Matzinger, Polly, Ph.D. Senior Investigator, LCMI |
Immunology, tolerance, transplantation, dendritic cells, oral tolerance, self tolerance, hemophilia, danger model |
| Metcalfe, Dean D., M.D. Laboratory Chief, LAD |
Mastocytosis, mast cells, serotonin, ROS, nitric oxide, asthma, allergy, basophils, Th2 cells, IL-4, anaphylaxis |
| Miller, Louis H., M.D. Chief, MVDB |
Malaria pathogenesis, malaria vaccines, cytoadherence to placenta and endothelium, red cell invasion |
| Moss, Bernard, M.D., Ph.D. Laboratory Chief, LVD |
Poxvirus pathogenesis, poxvirus immunity, vaccinia virus, transcription, MVA, smallpox vaccine |
| Muljo, Stefan Ph.D. Senior Investigator, LI |
Hematopoietic stem cells, B cell development, post-transcriptional regulation, non-coding RNAs, RNA-binding proteins |
| Munster, Vincent, Ph.D. Investigator, LV |
Evolution, viral pathogens, emerging infectious diseases, biodefense |
| Murphy, Brian R., M.D. Laboratory Co-Chief, LID |
RSV, parainfluenza virus, croup, bronchiolitis, vaccines, live-attenuated virus vaccines, dengue, WNV, TBEV |
| Murphy, Philip M., M.D. Laboratory Chief, LMI |
Inflammation, chemotaxis, chemokine, AIDS, G protein-coupled receptor, Alzheimer's disease, atherosclerosis |
| Nash, Theodore, M.D. Senior Investigator, LPD |
Giardia lamblia, microsporidium, intestinal infection, diarrhea, protozoa, parasite |
| Nutman, Thomas, M.D. Assistant Chief, LPD |
Filaria, loiasis, filariasis, onchocerciasis, strongyloidiasis, albendazole, lymphedema, cytokines |
| Otto, Michael, Ph.D. Investigator, LHBP |
Staphylococcus epidermidis, Staphylococcus aureus, MRSA, catheter infection, biofilms, quorum sensing |
| Peterson, Karin, Ph.D. Investigator, LPVD |
Emerging infectious diseases, pediatric infectious diseases, therapeutics |
| Pierce, Susan K., Ph.D. Laboratory Chief, LIG |
B lymphocyte, lipid rafts, B cell receptor, BCR, FRET imaging, TIRF microscopy, plasma cells, malaria vaccine |
| Pierson, Theodore, Ph.D. Investigator, LVD |
Flavivirus, West Nile virus, dengue, humoral immune response, antibody, antibody-mediated enhancement of infection |
| Pletnev, Alexander, Ph.D. Senior Investigator, LID |
Neurotropic flaviviruses, tickborne encephalitis virus, West Nile virus, live-attenuated virus, vaccine research |
| Polis, Michael, M.D. Senior Clin. Investigator, LIR |
HIV/AIDS, emerging infections, tuberculosis, international collaborations, clinical research |
| Priola, Suzette, Ph.D. Senior Investigator, LPVD |
Transmissible spongiform encephalopathies, scrapie, prion diseases, TSE therapeutics, TSE species barriers |
| Prussin, Calman, M.D. Investigator, LAD |
Asthma, allergy, T cells, tolerance, therapy, Th2 cells, IgE, IL-4, immunomodulation |
| Purcell, Robert H., M.D. Laboratory Co-Chief, LID |
Hepatitis viruses, select agents, vaccines, antibodies, Kawasaki disease, HAV, HBV, HCV, HEV |
| Quinn, Thomas, M.D., M.Sc. Senior Investigator |
Chlamydia, sexually transmitted diseases, STIs, HIV, AIDS, heterosexual transmission, international AIDS |
| Rosa, Patricia, Ph.D. Senior Investigator, LZP |
Borrelia burgdorferi, spirochete, Lyme disease, molecular genetics, tickborne, linear plasmids, adaptive response |
| Sacks, David L., Ph.D. Senior Investigator, LPD |
Cutaneous leishmaniasis, leishmania vector biology, sand flies, IL-12, IL-10, Tregs, dendritic cells, DNA vaccines, galectin |
| Scott, Dana, D.V.M. Investigator, RMVB |
Imaging, surgical modeling |
| Sher, Alan, Ph.D. Laboratory Chief, LPD |
Toxoplasmosis, immunoregulation, dendritic cells,Mycobacterium tuberculosis, Trypanosoma cruzi, Toll-like receptors, MyD88 |
| Shevach, Ethan M., M.D. Senior Investigator, LI |
Control of autoimmunity by regulatory T cells, T-cell activation, cell surface antigens |
| Siebenlist, Ulrich K., Ph.D. Senior Investigator, LIR |
Mechanisms of activation of NF-κB, signal transduction, Bcl-3, BAFF |
| Silver, Jonathan E., M.D. Senior Investigator, LMM |
Retrovirus- cell interactions, HIV, MLV, virus receptor |
| Steele-Mortimer, Olivia, Ph.D. Senior Investigator, LICP |
Akt/PKB, apoptosis, cell biology, gastroenteritis, Salmonella enterica |
| Strebel, Klaus A., Ph.D. Senior Investigator, LMM |
Retrovirus genes, HIV-1, Vpu, Vif, virus-host interactions, accessory proteins, protein degradation, APOBEC3G |
| Strober, Warren, M.D. Senior Investigator, LCIM |
Inflammatory bowel disease, Crohn's disease, mucosal immunity, IL-12, CARD15 (NOD2), CARD 4 (NOD1), peptidoglycan |
| Su, Xinzhuan, Ph.D. Senior Investigator, LMVR |
Malaria drug resistance; plasmodium sexual development; malaria genetics, genomics, evolution, population genetics |
| Sun, Peter, Ph.D. Senior Investigator, LIG |
Structural immunology, DC-SIGN, gp120, BIAcore, X-ray crystallography |
| Taubenberger, Jeffrey, M.D., Ph.D. Senior Investigator, LID |
Influenza pathogenesis, pandemic influenza, influenza virus virulence factors |
| Wellems, Thomas E., M.D., Ph.D. Laboratory Chief, LMVR |
Malaria drug resistance, disease virulence, genetics; hemoglobinopathies, antigenic variation, chloroquine, quinine |
| Yewdell, Jonathan W., M.D., Ph.D. Senior Investigator, LVD |
Viral immunity, antigen presentation/processing, MHC class I molecules, ubiquitin, proteasome, vaccines |
List of abbreviations
| Abbreviation | Definition |
|---|---|
| CMB | Comparative Medicine Branch |
| CRC | Mark Hatfield Clinical Research Center |
| DIR | Division of Intramural Research |
| LAD | Laboratory of Allergic Diseases |
| LBD | Laboratory of Bacterial Diseases |
| LCIM | Laboratory of Clinical Immunology and Microbiology |
| LCMI | Laboratory of Cellular and Molecular Immunology |
| LHBP | Laboratory of Human Bacterial Pathogenesis |
| LICP | Laboratory of Intracellular Parasites |
| LID | Laboratory of Infectious Diseases |
| LIG | Laboratory of Immunogenetics |
| LIP | Laboratory of Immunopathology |
| LIR | Laboratory of Immunoregulation |
| LISB | Laboratory of Immune System Biology |
| LMI | Laboratory of Molecular Immunology |
| LMM | Laboratory of Molecular Microbiology |
| LMVR | Laboratory of Malaria and Vector Research |
| LPD | Laboratory of Parasitic Diseases |
| LPVD | Laboratory of Persistent Viral Diseases |
| LVD | Laboratory of Viral Diseases |
| LZP | Laboratory of Zoonotic Pathogens |
| MVDB | Malaria Vaccine Development Branch |
| RML | Rocky Mountain Laboratories |
| RMVB | Rocky Mountain Veterinary Branch |
| RTB | Research Technologies Branch |
| TW | Twinbrook |