Volume 9, Issue 5, November 2020

In the first US urban jurisdiction case series summarizing findings of enhanced case investigation of hospitalized pediatric COVID-19 patients, household transmission was frequent, and all hospitalized patients were found to have an underlying comorbidity or coinfection.

We describe clinical characteristics and outcomes of 29 SARS-CoV-2–infected children with cancer. In comparison to adult oncology patients, children presented a milder clinical course. A substantial number of them continued their anticancer treatment without major modifications.

Acute otitis media (AOM) is a well-known complication of respiratory syncytial virus (RSV) infection. RSV immunization could decrease RSV-associated AOM. We review the role of RSV in AOM and suggest research strategies to assess the impact of RSV immunization.

The majority of patients singly infected with enteroaggregative Escherichia coli, enteropathogenic E. coli, or enterotoxigenic E. coli present with mild, self-limited, gastrointestinal (GI) complaints. Further research is needed to determine what role these pathogens might play in children who present with chronic or inflammatory GI symptoms.

We review current knowledge, epidemiology, clinical presentation, diagnostics, management, prevention, and preparedness for children with severe acute respiratory syndrome coronavirus 2 infections, listing resources, outlining research opportunities, and advocating for the unique needs of children in coronavirus 2019 pandemic response.