An official website of the United States government.
Institute for In Vitro Sciences, Inc.
A searchable citation database and links to full-text documents on alternative methods in toxicology.
Toxicology
Interagency Coordinating Committee on the Validation of Alternative Methods.
Links to information about the reviews of alternative test methods, the respective categories of toxicity, and/or the ICCVAM Working Group assigned to the assays.
Organisation for Economic Co-operation and Development.
Provides internationally agreed testing methods used by government, industry and independent laboratories to characterize potential hazards of new and existing chemical substances.
DHHS. NIH. National Institute of Environmental Health Sciences. National Institutes of Health.
Describes how to use in vitro cytotoxicity tests to estimate starting doses for acute oral lethality assays.
DHHS. Food and Drug Administration.
June 2012- Includes guidance regarding the use of alternatives to the rabbit pyrogen test (RPT) and the bacterial endotoxins test (BET) for detecting pyrogens in pharmaceuticals and other products. Examples of alternative assays cited include the recombinant horseshoe crab Factor C assay and monocyte activation type pyrogen tests (MATs).
US Environmental Protection Agency.
US Environmental Protection Agency. (2020). New approach methods work plan: Reducing use of animals in chemical testing (Work Plan EPA 615B2001; p. 21).
EPA uses information from a broad range of animal tests to evaluate the potential risks of chemicals, assess potential impacts on the environment, and approve chemicals for certain uses. Given the large number of chemicals regulated by EPA, the number of animals used to generate the necessary information is substantial. EPA’s New Approach Methods (NAMs) Work Plan was created in response to EPA Administrator Andrew Wheeler’s 2019 directive to prioritize agency efforts and resources toward activities that will reduce the use of animal testing while continuing to protect human health and the environment. This work plan was developed by experts across the agency to set the objectives and strategies for using New Approach Methods to meet the ambitious goals set out in the Administrator’s directive.
International Society of Regulatory Toxicology and Pharmacology.
The objective of this workshop [was] to explore progress to date in implementing new, revised and alternative toxicological test methods across regulatory evaluation frameworks and decision-making programs in the U.S., identify barriers to progress and explore potential bridges to facilitate overcoming such barriers. These barriers may be technical, regulatory, economic or societal. Slides and speakers notes for all presentations are also available.
The first step in a European research initiative to address the long term strategic target of "Safety Evaluation Ultimately Replacing Animal Testing (SEURAT)".
U.S. Environmental Protection Agency.
EPA’s ToxCast uses high-throughput screening methods and computational toxicology approaches to generate data and predictive models on chemicals.
European Commission. Joint Research Centre. Institute for Health and Consumer Protection.
A tool to provide information on the status of alternative methods as they progress from scientific protocols to validation for being used in a regulatory context.
Access: free online