Contents
16 December 2020
Vol 12, Issue 574
Vol 12, Issue 574
Report
- Lung transplantation for patients with severe COVID-19
Some patients with severe COVID-19 develop end-stage pulmonary fibrosis for which lung transplantation may be the only treatment.
Research Articles
- Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species
CD25-biased human IL-2 complexes stimulate regulatory T cells in freshly isolated human T cells ex vivo and in mice and rhesus macaques in vivo.
- Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis
Chi3l1/YKL-40 is regulated by BMAL1 in astrocytes and influences AD pathogenesis in both mouse models and humans.
- Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1
Pharmacological inhibition of a stress-protective transcription factor provides proof of concept for treatment of therapy-resistant cancer.
- Wireless sensors for continuous, multimodal measurements at the skin interface with lower limb prostheses
Wireless, soft sensors continuously monitor pressure and temperature at the interface between a residual limb and a prosthesis.
- Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease
Longitudinal analysis in 80 patients shows that mutant huntingtin and neurofilament light could predict Huntington’s disease progression.
- Plasma exosomal miR-375-3p regulates mitochondria-dependent keratinocyte apoptosis by targeting XIAP in severe drug-induced skin reactions
Circulating exosomal miR-375-3p promotes keratinocyte apoptosis via XIAP repression in Stevens-Johnson syndrome and toxic epidermal necrolysis.
Editors' Choice
- Quarterly picks from the editors
The Science Translational Medicine editors highlight interesting translational ties across select articles published recently in the Science family of journals.
- Reprogramming to help the old see like the young
Transcription factors associated with pluripotency restore molecular and functional characteristics resembling youth in aged mouse retinal ganglion cells.
- Metabolic vulnerabilities of intratumoral T cells and tumor cells
Tumor-infiltrating CD8+ T cells exhibit more metabolic vulnerabilities than tumor cells.
- Brain rejuvenation by inhibiting stress response
Age-related cognitive decline can be reversed with small molecule inhibition of the stress response pathway.
About The Cover
ONLINE COVER SHIELDing the Lung. Infection with SARS-CoV-2, the pathogen that causes COVID-19, can result in serious lung damage. For patients with severe COVID-19, lung transplantation may be their only option for survival (Bharat et al.). The cover image shows biopsies of human lung tissue (x10 magnification) treated with the SHIELD method to reveal the intricate matrix of collagen that provides structure to the lung (blue). The middle image shows healthy lung tissue with a normal collagen matrix, whereas the left and right images reveal complete breakdown of the collagen matrix in lung tissue from two patients with severe COVID-19. [CREDIT: MELISSA QUERREY/NORTHWESTERN UNIVERSITY]
