Contents
15 December 2020
Vol 13, Issue 662
Vol 13, Issue 662
Research Articles
- Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner
A sex-specific prion-amyloid interaction predicts that some Alzheimer’s disease therapies may not work in female patients.
- Structural basis for transcriptional coactivator recognition by SMAD2 in TGF-β signaling
A disordered region in the transcriptional coactivator CBP adopts a helical conformation when bound to SMAD2.
Editors' Choice
- Establishing patterns of signaling
The phosphorylation pattern of a GPCR C-terminal tail determines the effect on arrestin recruitment and conformation.
About The Cover
Online Cover This week features a Research Article that finds that the glutamate receptor mGluR5 may be a viable Alzheimer’s disease (AD) drug target only in male patients because of the sex-selective presence of cellular prion protein, which bridges the interaction between the receptor and β-amyloid. The image shows β-amyloid plaque staining in brain slices from male and female AD-model mice treated with an mGluR5 antagonist. [Image: Abd-Elrahman et al./Science Signaling]
