This Special Emphasis Notice (SEN) (https://grants.nih.gov/grants/guide/notice-files/NOT-HS-16-009.html) informs the research community that AHRQ is interested in funding applications that will conduct research on safe health IT practices specifically related to the design, implementation, usability, and safe use of health IT by all users, including patients. These projects would generate new evidence on safe health IT practices that could be used by the Office of the National Coordinator for Health IT, the Food and Drug Administration, the Centers for Medicare and Medicaid Services and others to inform health IT certification and other forms of policy guidance.