Resources for Scientists

• Bioethics
  The Bioethics Program is a part of the NIEHS' Ethics Program that provides educational, scholarly, and administrative support for research integrity at the NIEHS.
• Rigor and Reproducibility  at NIH
  Two of the cornerstones of science advancement are rigor in designing and performing scientific research and the ability to reproduce biomedical research findings.

Clinical Research Unit Resources

• Patient Protections
  The overall mission of the Office of Human Research Compliance (OHRC) is to manage a comprehensive Human Research Protection Program at the National Institute of Environmental Health Sciences (NIEHS).
• Policy for Data and Safety Monitoring of Human Subject Research Studies
  The National Institutes of Health (NIH) requires the monitoring activities of all NIH-sponsored or -conducted clinical studies to be commensurate with their risks, nature, size, and complexity.

DNA Databases

• Alu Pairs Databases
  This map file is a subfile of repbase(Genetic Information Research Institute(GIRI)), derived by comparing genomic sequences in the GenBank database(release 112.0, National center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD) with the Alu consensus sequence, was made in April 1999 and is maintained at the GIRI, Sunnyvale, CA).
• Environmental Genome Project 
  The NIEHS Environmental Genome Project is a multi-disciplinary, collaborative effort focused on examining the relationships between environmental exposures, inter-individual sequence variation in human genes and disease risk in U.S. populations.
• Environmental Polymorphisms Registry (EPR) 
  The Environmental Polymorphisms Registry (EPR) is a long-term research project to collect and store DNA from up to 20,000 North Carolinians in a biobank.
• Mouse Genome Resequencing Project 
  This is the link to download the imputed genotypes at all 8 million (8,285,037) SNPs discovered by NIEHS/Perlegen resequencing project.
• Human DNA Polymerase gamma Mutation
  Human DNA polymerase is composed of two subunits, a 140 kDa catalytic subunit encoded by the POLG on chromosome 15q25, and a 55kDa accessory subunit encoded by the POLG2 gene on chromosome 17q23-24.
• Mircoarray Group cDNA Closes Search
  NIEHS Microarray Center Clone Set Search Form.

Literature Databases

• Bisphenol A Research Article Citation List
  The NIEHS and National Toxicology Program have developed an integrated research program to address data gaps and inform decision making about the health effects of BPA.
• Climate Change and Human Health Literature Portal 
  NIEHS provides a curated database of global, peer-reviewed scientific literature and high-quality gray literature on the impacts of climate change on human health.
• Environmental Health Economic Analysis Annotated Bibliography
  The Environmental Health Economic Analysis (EHEA) Annotated Bibliography is a searchable database that summarizes key attributes from over 70 curated environmental health science articles that include economic analyses.
• Nanotechnology Notable Papers and Advances
  NIEHS is working to understand the health effects of human exposure to nanomaterials.
• Supported Publications on Per- and Polyfluoroalkyl Substances (PFAS)
  NIEHS is working to understand the health effects of human exposure to per- and polyfluoroalkyl substances (PFAS).

Toxicology Databases

• Chemical Effects in Biological Systems (CEBS)
  The CEBS database houses data of interest to environmental health scientists. CEBS is a public resource, and has received depositions of data from academic, industrial and governmental laboratories.
• Comparative Toxicogenomics Database
  TD is a robust, publicly available database that aims to advance understanding about how environmental exposures affect human health. It provides manually curated information about chemical–gene/protein interactions, chemical–disease and gene–disease relationships. These data are integrated with functional and pathway data to aid in development of hypotheses about the mechanisms underlying environmentally influenced diseases.
• Nanomaterial Registry 
  The Nanomaterial Registry is an authoritative, fully curated resource that archives research data on nanomaterials and their biological and environmental implications.

• Climate Change and Human Health Literature Portal
  The Climate Change and Human Health Literature Portal is a knowledge management tool for locating the most relevant scientific literature on the health implications of climate change.
• NIH Collaborative Research Exchange (CREx) at the National Institutes of Health
  The NIH Collaborative Research Exchange (CREx) is a collaborative research exchange for the NIH Intramural Research Program.
• Impacts of Climate Change on Human Health in the United States: A Scientific Assessment 
  Climate change is affecting the health of Americans. As the climate continues to change, the risks to human health will grow, exacerbating existing health threats and creating new public health challenges. This assessment significantly advances what we know about the impacts of climate change on public health, and the confidence with which we know it. While all Americans will be affected by climate change, the report recognizes populations of concern, such as children, the elderly, outdoor workers, and those living in disadvantaged communities, who are disproportionately vulnerable.
• Environmental Health Perspectives (EHP) 
  EHP is a monthly peer-reviewed journal of research and news published with support from the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, U.S. Department of Health and Human Services.

• Classroom Activities for Scientists
  The Environmental Health Science Education website provides educators, students and scientists with easy access to reliable tools, resources and classroom materials.
• Core Facilities
  NIEHS facilities provide state-of-the-art equipment and expertise, which support in-house (intramural) research activities at the institute. These shared and core services are available to NIH employees only.
• Electron Paramagnetic Resonance/Electron Spin Resonance (EPR/ESR)
  Electron paramagnetic resonance (EPR), also known as electron spin resonance (ESR), is a sophisticated spectroscopic technique that detects free radicals in chemical and biological systems.
• International Myositis Assessment & Clinical Studies Group (IMACS)
  The International Myositis Assessment and Clinical Studies Group (IMACS) is a coalition of health care providers and researchers with experience and interest in the myositis syndromes.
• Molecular Microscopy Consortium
  The Molecular Microscopy Consortium allows scientists from NIEHS, the University of North Carolina at Chapel Hill, and Duke University to use single particle cryo-electron microscopy and other tools in molecular microscopy to solve macromolecular structures at the atomic level.

  This video shows how the NIEHS Cryo-EM Facility generates 3D images of large proteins. (3:53)

• Speakers Bureau
  NIEHS scientists, technicians, and administrators are also available to talk about their job responsibilities, as well as their educational and career experiences.

• Laser Capture Microdissection
  Laser Microdissection provides information to NIEHS researchers interested in the process of microdissection.
• Immunolhistochemistry
  The Immunohistochemistry staff has established optimized protocols for immunohistochemistry, immunocytochemistry, and immunofluorescence staining.
• Tissue Collection, RNA Extraction of High Quality RNA
  Studies requiring gene expression analysis by microarray methods require the extraction of high quality RNA.

• Biostatistics & Computational Biology
  NIEHS has several resources available to researchers, both inside and outside of the institute.
• Epidemiology
  The Epidemiology Branch addresses the mission of the NIEHS by carrying out basic and applied research on the effects of the environment on human health.
• Free Radical Metabolism
  The Free Radical Metabolism Group studies free radicals, which are atoms or molecules with unpaired electrons in an outer electron shell.
• Nuclear Magnetic Resonance
  The Nuclear Magnetic Resonance (NMR) Group performs fundamental research on biological systems aimed at providing insight into the molecular mechanisms that underlie problems of environmental concern.
• Public Electron Paramagnetic Resonance Software Tools
  NIEHS has produced software for Electron Paramagnetic Resonance analysis since 1983.

• Technology Transfer
  The primary mission of this office is to enable NIEHS intramural researchers to more effectively interact with their counterparts — in academia, nonprofit organizations, and the private sector, such as biotechnology and pharmaceutical companies — to establish collaborative relationships that will benefit human health.

• The Digitized Atlas of Mouse Liver Lesions
  The Atlas provides hundreds of color photographs and slides of various types of rodent liver lesions. Readers can search by both subject and by pathology.
• Mouse & Rat Embedding Suggestions
  These images provide suggestions to scientists in the form of detailed illustrations, photos, interactive guides, and suggestions. These suggestions cover both rat and mouse tissues.
• NTP Nonneoplastic Lesion Atlas 
  A guide for standardizing terminology in toxicology pathology for rodents.
• Revised Guides for Organ Sampling and Trimming in Rats and Mice
  This is the first part of a series of three articles on trimming instructions of rat and mouse protocol organs and tissues in regulatory type toxicity studies.