Find a Clinical Trial
See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.
Arthritis
Rheumatoid Arthritis Studies
NIAID is committed to advancing the understanding of how and why autoimmune diseases such as rheumatoid arthritis occur.
Asthma
A Trial of Mepolizumab Adjunctive Therapy for the Prevention of Asthma Exacerbations in Urban Children (MUPPITS-2)
The purpose of this study is to see if treatment with a medication called Nucala® (mepolizumab), given along with standard asthma care, makes children less likely to have asthma attacks.
Airway Temperature (RATE)
Airway irritation, cough and bronchial spasm are common symptoms in patients with airway inflammatory diseases such as asthma. The primary focus of this exploratory study is to determine if there is an increase in tissue temperature in airway mucosa during asthma exacerbation.
Cockroach Immunotherapy in Children and Adolescents (CRITICAL)
Scientific evidence has shown that, over the past two decades, the combination of cockroach allergy and cockroach exposure is one of the most important factors contributing to the dramatic increase in asthma morbidity seen in inner city children with asthma.
Lung-Resident Memory Th2 Cells in Asthma
Determining how memory T helper type 2 (Th2) initiate recall responses to aeroallergens has the potential to change the therapeutic approach to allergic asthma, the most common asthma subtype.
Preventing Asthma in High Risk Kids (PARK)
This trial is a randomized, double-blind, placebo controlled trial designed to test whether two years treatment of preschool children aged 2-3 years of age at high risk for asthma with omalizumab (anti-IgE) for two years will prevent the progression to childhood asthma, as reflected by a reduction in the prevalence of active asthma in the Final 12 months during 2 year observation period off study drug.
Registry for Asthma Characterization and Recruitment 2 (RACR2)
There is a need for people to take part in research studies to learn more about diseases and how to treat them.
Sorting and Expression Profiling of Airway Cells From Humans (The SEARCH Study) (SEARCH)
This will be a single site, mechanistic study of asthmatic subjects and healthy, non-asthmatic controls involving a baseline characterization visit and a research bronchoscopy visit.
Study of the Inflammation and Airway Changes That Occur After Exposure to Allergen in Asthmatics (ACE)
This protocol describes a single site mechanistic study to investigate microRNAs (miRNAs) that are differentially expressed in the airway epithelium of patients with asthma at baseline and in response to allergen challenge.
Upper Airway Microbial Development During the First Year of Life
This study tests the hypothesis that an increase in pathogenic bacteria within the infant airway leads to increased airway inflammation, decreased airway function and ultimately airway obstruction throughout the first one to two years of life.
Autoimmune Diseases
EPIC Study
The primary objective of this study is to further characterize the natural history of idiopathic CD4 lymphocytopenia (ICL) while also investigating the genetic, environmental, and immunologic features of the condition.
Chronic Granulomatous Disease (CGD)
Evaluation of Patients With Immune Function Abnormalities
This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation.
Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations
To learn more about when and why IBD may develop in some people with primary immune dysregulation.
Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995
This study will determine the long term medical condition and daily functioning of participants with CGD after a transplant and if possible, compare these results to participants who do not undergo a transplant.
Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous Disease
To see if RFA is a safe and effective treatment for CGD-related liver abscesses.
Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous Disease
This study is a prospective non-controlled, non-randomized Phase I/II clinical trial to assess the safety, feasibility and efficacy of cellular gene therapy in patients with chronic granulomatous disease.
Use of G-CSF to Obtain Blood Cell Precursors
This protocol is designed to study the techniques needed to develop gene therapy or other treatments for certain inherited immune system diseases.
Chronic Granulomatous Disease (CGD) and Hyper-Immunoglobulin M (Hyper-IgM) Syndromes and Primary Immune Deficiency Diseases (PIDDs) and Wiskott-Aldrich Syndrome (WAS) and X-Linked Agammaglobulinemia (XLA) and X-Linked Lymphoproliferative Disease (XLP)
Participation in a Research Registry for Immune Disorders
To collect data on people with primary immune deficiency disorders.
Coronaviruses
AstraZeneca Study of COVID-19 Vaccine Candidate AZD1222
The trial primarily is designed to determine if the vaccine candidate, AZD1222, can prevent symptomatic COVID-19 after two doses.
Big Effect Trial (BET) for Finding Promising Treatments of COVID-19
The primary purpose of the ACTIV-5/BET study is to evaluate the clinical efficacy of different investigational therapeutics in adults hospitalized for severe COVID-19.
Cardiopulmonary Inflammation and Multi-System Imaging During COVID-19 Infection in Asymptomatic and Symptomatic Persons
A study to learn how coronavirus affects different organs of the body and the function of the body's immune system.
COVID-19 Antibody Treatment Study for Preventing SARS-CoV-2 Infection in Nursing Home Residents and Staff
This trial will assess whether LY-CoV555, a potential COVID-19 antibody treatment, can prevent SARS-CoV-2 infection among people at high risk of exposure due to residing or working in skilled nursing or assisted living facilities.
COVID-19-Recovered Specimen Collection Research Study
The NIAID Vaccine Research Center is looking for volunteers who are fully recovered from confirmed COVID-19 infection to donate blood for a research study. The aim of the study is to further define and understand specific immune responses.
Drug Treatment Study for Outpatients With COVID-19
This study looks at the safety and effectiveness of different drugs in treating COVID-19 in outpatients. Participants in the study will receive an experimental therapy or a placebo.
Drug Treatment Study of Individuals With Mild COVID-19
This research study is about an experimental drug for COVID-19 called NT-I7. We are studying whether the experimental drug is safe for people with COVID-19. We also want to see if it might help treat COVID-19 by supporting the immune system.