VERA tools and supporting infrastructure can be used to solve neutronics, thermal-hydraulics, fuel performance, and coupled physics problems with advanced uncertainty quantification tools. VERA integrates physics components based on science-based models, state-of-the-art numerical methods, and modern computational science, and is verified and validated using data from operating PWRs, single-effect experiments, and integral tests. VERA is optimized for efficient execution on multiple platforms, including leadership-class computers, advanced architecture platforms now under development, and industrial engineering workstation clusters. VERA’s integrated, coupled solutions provide a more realistic representation of the reactor’s behavior. VERA is developing and applying models, methods, data, and understanding to accelerate future advances in the development of this cleaner energy source.