Developing and improving functional genomics (RNAi and CRISPR/Cas9) screening approaches to better understand gene function and identify biologically-relevant targets.
NCATS' state-of-the-art RNAi screening facility accepts proposals from any NIH researcher. NCATS staff assist investigators with all stages of project planning and execution, from assay development through genome-wide small-interfering RNA (siRNA) screens, informatics and pathway analysis, and rigorous follow-up.