DEA Annual Reports
| FY | Report Cover Image | Image Title - Description |
|---|---|---|
| 2015 |  | The RAS Initiative - The RAS family of oncogenes were the first oncogenes identified in human cancer cell DNA in 1981. Activating mutations in RAS genes, in particular KRAS, are observed in about 35 percent of lung adenocarcinomas and more than 90 percent of pancreatic cancers. |
| 2014 |  | Molecular Analysis for Therapy Choice (NCI-Match): A Novel Clinical Trial - The goal of NCI-MATCH is to provide clinical evidence that a drug targeting a particular molecular profile may also be effective in the treatment of more than one tumor type. |
| 2013 |  | A Precision Medicine Research Strategy - To Integrate a Taxonomic Classification of Cancer and Translate it into the Clinic. The concept that developed, that of Precision Medicine, includes four basic premises; Information Commons, Knowledge Network, Taxonomic Classifiers, and Precision Medicine. |
| 2012 |  | Molecular Diagnosis of Lymphoid Malignancies - Diffuse large B cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphona is iagnosed in more than 20,000 individuals per year in the United States. |
| 2011 |  | Deciphering the Complexity of Drug Resistance in Cancer - Cellular and molecular approaches to the study of multidrug resistance in cancer. |
| 2010 |  | Personalized Immunotherapy - Identify the Cancer Antigen and Create the Anti-Tumor T Cell |
| 2009 |  | Glioblastoma-Derived Tumor Stem Cells - The generation of tumor stem cell-derived neurospheres from patient-derived glioblastoma tissue. |
| 2008 |  | Interleukin-15 in the Life and Death of Lymphocytes: A Target for Cancer Therapy and Vaccine Design - The structure of IL-15; A model of IL-15 receptor alpha chain (IL-15Rα) presentation of IL-15 in trans to neighboring NK and CD8+ T cells. |
| 2007 |  | Identifying Interleukin-7 As a Master Regulator of T Cell Homeostasis: Clinical Implications and New Therapeutic Opportunities - Protein Data Bank Model of IL-7 Engaging the IL7R on the surface of a T cell. |
| 2006 |  | The Genetic Basis of Kidney Cancer Opportunities for Disease-Specific Targeted Therapy - The genes associated with the development of cancer of the kidney have in common their interaction with pathways that control oxygen and nutrient sensing. |
| 2005 |  | A Vaccine to Prevent Cervical Cancer and Other Diseases Caused by HPV Infection - 1. Authentic bovine papillomavirus virions; 2. Bovine papillomavirus-like particles; 3. Human papillomavirus-like particles; 4. 3-D reconstruction of cryo-electron micrograph of authentic papillomavirus virion (blue) coated with neutralizing antibody (red). |
| 2004 |  | Molecular Imaging for Cancer - Two different types of molecular imaging techniques applied to cancer detection: positron emission tomography-computed tomography (PET-CT) fusion imaging; magnetic resonance images (MRI) using a superparamagentic imaging agent [monocrystalline iron oxide nanoparticle (MION)] |
| 2003 |  | Chemical Genetics and New Treatments for Cancer - Results of screening small molecules in the cytoblot assay for their ability to cause hyperacetylation of tubulin (left) and histone (right) proteins in lung epithelial cells. |
| 2002 |  | Molecular Diagnosis of Cancer - Photomicrographs of lymph node biopsies from two patients with diffuse large B cell lymphoma. |
| 2001 |  | Immunotoxin Therapy of Hairy Cell Leukemia With BL22 |