Click on the links below or scroll down to view open opportunities in each section.
- Requests for Applications
- Requests for Information (when available)
- Program Announcements
- Notices
- Challenges (when available)
Get the latest public health information from CDC.
Get the latest research information from NIH.
Click on the links below or scroll down to view open opportunities in each section.
NIH Blueprint for Neuroscience Research: Functional Neural Circuits of Interoception (R01, Clinical Trial Not Allowed)
RFA-AT-21-003 · Posted Date: 09/02/2020
Urgent Phase I/II Clinical Trials to Repurpose Existing Therapeutic Agents to Treat COVID-19 Sequelae (U01 Clinical Trial Required)
RFA-TR-20-003 · Posted Date: 08/05/2020
Ethical Issues in Translational Science Research (R01 Clinical Trial Optional)
RFA-TR-20-001 · Posted Date: 10/23/2019
HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed)
RFA-NS-20-009 · Posted Date: 10/03/2019
HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 - Clinical Trial Not Allowed)
RFA-NS-20-011 · Posted Date: 10/01/2019
Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical Trial Not Allowed)
PA-21-071 · Posted Date: 11/16/2020
Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
PA-20-272 · Posted Date: 10/09/2020
Successor-in-Interest (Type 6 Parent Clinical Trial Optional)
PA-20-275 · Posted Date: 10/06/2020
Drug Development Collaboratory (UG3/UH3 Clinical Trial Required)
PAR-20-301 · Posted Date: 09/18/2020
Research to Improve Native American Health (R21 Clinical Trials Optional)
PAR-20-214 · Posted Date: 08/17/2020
SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance (SB1, Clinical Trial Not Allowed)
PAR-20-128 · Posted Date: 07/10/2020
NICHD Research Education Programs (R25 Clinical Trial Not Allowed)
PAR-20-250 · Posted Date: 06/29/2020
Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)
PA-20-222 · Posted Date: 05/29/2020
NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)
PA-20-207 · Posted Date: 05/07/2020
Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (R01 Clinical Trials Not Allowed)
PAR-20-165 · Posted Date: 04/13/2020
Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (R21 Clinical Trials Not Allowed)
PAR-20-168 · Posted Date: 04/13/2020
Non-Viral Technologies for in vivo Delivery of Genome Editors (R43/R44 Clinical Trial Not Allowed)
PAR-20-098 · Posted Date: 02/06/2020
Non-Viral Technologies for in vivo Delivery of Genome Editors (R41/R42 Clinical Trial Not Allowed)
PAR-20-109 · Posted Date: 02/06/2020
Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44 Clinical Trial Not Allowed)
PA-20-047 · Posted Date: 01/08/2020
Development of Highly Innovative Tools and Technology for Analysis of Single Cells (STTR) (R41/R42 Clinical Trial Not Allowed)
PA-20-025 · Posted Date: 01/07/2020
Limited Competition: Competitive Revision Awards for the Clinical and Translational Science Award (CTSA) Program (U54 Clinical Trial Optional)
PAR-19-337 · Posted Date: 08/07/2019
SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance (SB1, R44) Clinical Trial Not Allowed
PAR-19-334 · Posted Date: 08/05/2019
Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative Innovation Award, (U01 Clinical Trial Optional)
PAR-19-099 · Posted Date: 12/12/2018
Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project (IDG) (R43/R44 Clinical Trial Not Allowed)
PA-19-034 · Posted Date: 10/24/2018
Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project (IDG) (R41/R42 Clinical Trial Not Allowed)
PA-19-033 · Posted Date: 10/24/2018
Innovation Corps (I-Corps™) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial Not Allowed)
PA-19-029 · Posted Date: 10/17/2018
Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed)
PAR-18-953 · Posted Date: 10/04/2018
Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R03 Clinical Trial Not Allowed)
PAR-18-952 · Posted Date: 10/04/2018
Clinical and Translational Science Award (U54 Clinical Trial Optional)
PAR-18-940 · Posted Date: 09/27/2018
Administrative Supplements to Promote Diversity in Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed)
PA-18-837 · Posted Date: 06/20/2018
Innovative Therapies and Tools for Screenable Disorders (R21 Clinical Trial Optional)
PAR-18-691 · Posted Date: 03/01/2018
Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
PA-18-591 · Posted Date: 01/25/2018
Clinical Trial Planning: Therapeutic/Indication Pairing Strategies (U34) (Clinical Trials Not Allowed)
PAR-18-462 · Posted Date: 11/30/2017
Clinic Testing Therapeutic/Indication Pairing Strategies (U01 Clinical Trial Required)
PAR-18-332 · Posted Date: 10/20/2017
Clarification on Prohibition on Expending NIH Grant Funds for Covered Telecommunications Equipment or Services
NOT-OD-21-041 · Posted Date: 12/11/2020
Prohibition on Expending NIH Grant Funds for Covered Telecommunications Equipment or Services
NOT-OD-21-030 · Posted Date: 11/23/2020
NIH Implementation of the Revised Federal-wide Research Terms and Conditions
NOT-OD-21-029 · Posted Date: 11/17/2020
Extended Guidance for Applicants Preparing Applications During the COVID-19 Pandemic
NOT-OD-21-026 · Posted Date: 11/04/2020
Supplemental Information to the NIH Policy for Data Management and Sharing: Allowable Costs for Data Management and Sharing
NOT-OD-21-015 · Posted Date: 10/29/2020
Supplemental Information to the NIH Policy for Data Management and Sharing: Selecting a Repository for Data Resulting from NIH-Supported Research
NOT-OD-21-016 · Posted Date: 10/29/2020
Final NIH Policy for Data Management and Sharing
NOT-OD-21-013 · Posted Date: 10/29/2020
Supplemental Information to the NIH Policy for Data Management and Sharing: Elements of an NIH Data Management and Sharing Plan
NOT-OD-21-014 · Posted Date: 10/29/2020
Notice of Special Interest (NOSI): Repurposing Existing Therapeutics to Address the 2019 Novel Coronavirus Disease (COVID-19)
NOT-TR-21-006 · Posted Date: 10/23/2020
Notice Announcing Availability of Data Harmonization Tools for Social Determinants of Health (SDOH) via the PhenX Toolkit
NOT-MD-21-003 · Posted Date: 10/19/2020
Policy for Charging Personal Protective Equipment to NIH Grants and Cooperative Agreements as Direct Costs
NOT-OD-20-164 · Posted Date: 09/11/2020
Reminder: NIH Natural Disaster Policy Hurricane Laura
NOT-OD-20-172 · Posted Date: 09/11/2020
Notice of Change to Key Dates for PAR-18-940 Clinical and Translational Science Award (U54 Clinical Trial Optional)
NOT-TR-20-036 · Posted Date: 08/27/2020
NCATS Announces Plans to Publish the ASPIRE 2020 Reduction-to-Practice Challenge Prize Competition
NOT-TR-20-035 · Posted Date: 08/26/2020
Notice of Special Interest: Administrative Supplements for the U.S.-Japan Brain Research Cooperative Program (BRCP) - U.S. Entity (Admin Supp)
NOT-NS-20-024 · Posted Date: 05/05/2020
Notice to Extend the Expiration Date for PAR-18-332 "Clinic Testing Therapeutic/Indication Pairing Strategies (U01 Clinical Trial Required)"
NOT-TR-20-026 · Posted Date: 04/27/2020
Notice to Extend the Expiration Date for PAR-18-462 "Clinical Trial Planning: Therapeutic/Indication Pairing Strategies (U34) (Clinical Trial Not Allowed)"
NOT-TR-20-027 · Posted Date: 04/27/2020
Notice of Special Interest: NCCIH Administrative Supplements to NCATS CTSA Programs for Scholars Pursuing Complementary Health Research Career Development
NOT-AT-20-010 · Posted Date: 04/13/2020
Notice of Information: Change in NCATS Prior Approval Process for New CTSA Program Pilot Projects that Involve Human Subjects Research
NOT-TR-20-019 · Posted Date: 04/09/2020
Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements for Tissue Chips Research on the 2019 Novel Coronavirus
NOT-TR-20-016 · Posted Date: 04/09/2020
Notice of Special Interest: Clinical and Translational Science Award (CTSA) Program Administrative Supplements
NOT-TR-20-014 · Posted Date: 04/08/2020
Notice of NCATS' Participation in PA-20-135 "Emergency Competitive Revision to Existing NIH Awards (Emergency Supplement - Clinical Trial Optional)"
NOT-TR-20-013 · Posted Date: 04/08/2020
Notice of Transition to New System for Issuing Certificates of Confidentiality for Non-NIH Funded Research
NOT-OD-20-075 · Posted Date: 02/28/2020
Notice of Special Interest (NOSI): Availability of Administrative Supplements for the Rare Disease Clinical Research Network (RDCRN)
NOT-TR-20-006 · Posted Date: 02/27/2020
Notice of Special Interest: Research through NCATS’ Clinical and Translational Science Award (CTSA) Program: Collaborative Innovation Awards (U01 and R21)
NOT-TR-20-007 · Posted Date: 02/18/2020
Additional Guidance on the NIH Policy on the Use of a Single Institutional Review Board for Multi-Site Research
NOT-OD-20-058 · Posted Date: 01/22/2020
Notice of Special Interest (NOSI): Next-Generation Approaches to Renal Replacement Therapy Including Vascular Access
NOT-DK-19-027 · Posted Date: 10/09/2019
Extension of Certain Flexibilities for Prospective Basic Experimental Studies With Human Participants
NOT-OD-19-126 · Posted Date: 07/24/2019
Notice of Change to NOT-TR-19-014: Notice of Change to PAR-18-940 Clinical and Translational Science Award (U54 Clinical Trial Optional)
NOT-TR-19-026 · Posted Date: 07/05/2019
Notice of Special Interest: Administrative Supplements for Alternatives to the Use of Human Fetal Tissues for NIH Tissue Chip Programs
NOT-TR-19-019 · Posted Date: 04/18/2019
Notification of Upcoming Change in Federal-wide Unique Entity Identifier Requirements
NOT-OD-19-098 · Posted Date: 04/11/2019
Notice of Change to Key Dates for RFA-EB-18-003 "HEAL Initiative: Translational Development of Devices to Treat Pain (U18 Clinical Trial Not Allowed)"
NOT-NS-19-056 · Posted Date: 04/10/2019
Notice of Change to Key Dates for RFA-NS-19-016 "HEAL Initiative: Translational Devices to Treat Pain (UG3/UH3 Clinical Trial Optional)"
NOT-NS-19-053 · Posted Date: 04/10/2019
Notice of Change to Key Dates for RFA-NS-19-017 "HEAL Initiative: Translational Devices to Treat Pain (U44 Clinical Trial Optional)"
NOT-NS-19-054 · Posted Date: 04/10/2019
Notice of Change to Key Dates for RFA-NS-19-018 "HEAL Initiative: Clinical Devices to Treat Pain (UH3 Clinical Trial Optional)"
NOT-NS-19-055 · Posted Date: 04/10/2019
Notice of Change to PAR-18-940 Clinical and Translational Science Award (U54 Clinical Trial Optional)
NOT-TR-19-013 · Posted Date: 12/19/2018
Notice of Change to PAR-18-940 Clinical and Translational Science Award (U54 Clinical Trial Optional)
NOT-TR-19-010 · Posted Date: 11/07/2018
Notice of Change to PAR-18-953 Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed)
NOT-TR-19-012 · Posted Date: 10/29/2018
Notice of Change to PAR-18-952 Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R03 Clinical Trial Not Allowed)
NOT-TR-19-011 · Posted Date: 10/29/2018
Reinstatement of NIH SBIR Direct-to-Phase II Authority and Associated Updates to NIH SBIR Omnibus Solicitations
NOT-OD-19-019 · Posted Date: 10/15/2018
Additional Awards Eligible for PA-18-906 Research Supplements to Promote Diversity in Health-Related Research (Admin Supp)
NOT-OD-18-226 · Posted Date: 09/04/2018
Notice of Availability of Administrative Supplements for NIH Grants Focused on Down Syndrome to Address Specific Down Syndrome Research Objectives
NOT-OD-18-195 · Posted Date: 06/20/2018
Notice of Availability of Administrative Supplements for the NCATS Clinical and Translational Science Awards (CTSA) Program
NOT-TR-18-022 · Posted Date: 04/20/2018
Additional Awards Eligible for PA-18-592 Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers" (Admin Supp)
NOT-OD-18-153 · Posted Date: 03/15/2018
To find NCATS Requests for Proposals, visit FedBizOpps, type n01tr into the keyword field and click the search button.
Learn more about the NIH clinical trial requirements for grants and contracts and download slides that highlight policy changes.
This Notice informs the research community of the NCATS policy regarding support of clinical trial activities. The policy is designed to ensure compliance with the 21st Century Cures Act (Cures Act) as well as all pertinent statutes and existing NIH and NCATS policies; and considers the urgency of developing new treatments for rare diseases.
NCATS welcomes your NIH HEAL Initiative-related proposals to advance promising compounds and human cell-based models through preclinical development in collaboration with NCATS' intramural scientists.
As part of NIH HEAL Initiative, NCATS is applying breakthrough approaches of translational science to advance new treatments for opioid misuse and addiction and for pain. Learn more about NCATS' Role in the NIH HEAL Initiative.
Learn more about current funding opportunities for the Clinical and Translational Science Awards (CTSA) Program on the CTSA Program Funding Information page, including recent announcements and frequently asked questions.