Milestone 9.M

ADRD Specific Milestone

Develop diagnostics/biomarkers in asymptomatic individuals.

Success Criteria

Develop at least one improved imaging or fluid biomarker for AD, cerebrovascular disease (including the health of the neurovascular unit), and each of the ADRDs, to estimate future risk for cognitive impairment in asymptomatic individuals.
Conduct one or more studies that validate diagnostic and theragnostic utility of new biomarkers in asymptomatic populations, especially in minority groups and in middle age using population-based studies. Include evaluation of the relative clinical importance of different etiologies when more than one etiology is present.