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Key Initiatives

NCI has worked to leverage its role as the leader of the National Cancer Program to expand our understanding of cancer and to translate new knowledge into better cancer prevention and treatment. Although the majority of NCI’s funding supports investigator-initiated science, the institute also invests in major research initiatives to facilitate and support research on specific issues of importance to the cancer research enterprise. Some of these key initiatives include:

Cancer Moonshot℠

The cancer initiative is increasing resources and collaboration to make research advances available to patients across America. NCI is accepting applications for research grants that align with the goals of the Cancer Moonshot.

See Funding Opportunities
  • Image of transmission electron micrograph of SARS-CoV-2 virus particles, isolated from a patient.

    COVID-19 Information for Cancer Researchers

    During the COVID-19 pandemic, NCI is continuing to advance cancer research while helping in the response to the pandemic. Learn about NCI’s COVID-19 research efforts and find guidance for cancer researchers whose work is affected by the pandemic.

  • Two girls with ALL receiving chemotherapy

    Childhood Cancer Data Initiative (CCDI)

    The Childhood Cancer Data Initiative focuses on the critical need to collect, analyze, and share data to address the burden of childhood cancer. This initiative aims to make it easier for researchers to learn from each child with cancer.

  • The RAS Initiative

    NCI established this initiative to develop effective therapies against tumors that contain mutations in members of the RAS family of oncogenes. RAS genes are mutated in approximately one-third of all cancers. The RAS Initiative highlights NCI’s ability to bring together experts from across the research enterprise to address pressing scientific and clinical questions in cancer.

  • National Clinical Trials Network (NCTN)

    The cornerstone of NCI’s clinical trials program, NCTN is a network of organizations and clinicians that conduct large phase II and phase III clinical trials across the United States and Canada. These help establish new standards of care, set the stage for FDA approval of new therapies, test new approaches to radiation therapy and surgery, and validate new biomarkers. NCTN provides an infrastructure for NCI-funded treatment, screening, and diagnosis trials at over 3,000 clinical trials sites.

  • NCI Community Oncology Research Program (NCORP)

    NCORP is a community-based program that builds upon the scope and activities of NCI's previously supported community networks: the NCI Community Clinical Oncology Program (CCOP), Minority-Based CCOP, and NCI Community Cancer Centers Program (NCCCP). NCORP brings cancer clinical trials and cancer care delivery research to individuals in their own communities.

  • NCI Genomic Data Commons (GDC)

    NCI has established the GDC to store, analyze, and distribute cancer genomics data generated by NCI and other research organizations. The GDC provides an interactive system for researchers to access data, with the goal of advancing the molecular diagnosis of cancer and suggesting potential therapeutic targets based on genomic information. The GDC facilitates access to data generated by many existing and forthcoming NCI programs, including The Cancer Genome Atlas (TCGA) and Therapeutically Applicable Research to Generate Effective Treatments (TARGET).