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A specific collection of neurons in the basolateral amygdala, a brain region crucial for affect, was active when mice experienced pain. Deactivating this collection of neurons resulted in a loss...
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In the summer of 2019, Dr. Linda Dwoskin and her research team felt they were in a promising place in their decades-long search for a treatment for the 700,000 Americans...
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Substance use is common among people living with HIV and is associated with less successful HIV treatment outcomes. Integrating substance use services into HIV care is a promising strategy to...
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Cocaine can trigger release of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the ventral tegmental area of the midbrain in mice, and this may play a role in cocaine use disorder.
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Prenatal cannabis exposure (PCE) increased sensitivity to THC in male rats, but not female rats, during pre-adolescence. PCE increased dopamine release in response to THC and altered the properties of...
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We are prioritizing research into how the coexisting crises of COVID-19, HIV, and substance use, including the opioid crisis, combine to create a disastrous storm, taking lives and overtaxing America’s...
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Activity in the striatum of people who smoke changed less in response to positive feedback/reward than in nonsmokers; this effect was more pronounced with greater addiction severity. Activity of the...
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Concerted efforts and substantial investments in HIV prevention and care in the United States have resulted in considerable reduction in new diagnoses and death since the mid-1990s. To identify best...
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NIDA has begun drafting its strategic plan for 2021-2025, and to best inform that process, we are seeking input from the public and the scientific community.
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This study found that children’s risk of marijuana and alcohol use and attitudes toward marijuana were influenced by their parents’ marijuana use pattern over time.
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People with substance use disorders (SUD) can be at high risk for contracting this virus, either through injection drug use, or risky behaviors prompted by impaired judgment.
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The U.S. is now facing two intersecting health crises, the ongoing opioid overdose epidemic and the COVID-19 pandemic. Regrettably, each has the potential to exacerbate the effects of the other.
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We know that science itself is at its best when it is most inclusive, and humans are best when we embrace diversity. Conversations about systemic racial inequalities can be uncomfortable...
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International research teams analyzed several hundred thousand samples from 17 whole-exome sequencing studies to identify rare gene variants associated with smoking and alcohol use. They identified rare variants in 117...
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A new computational analysis suggests certain dopamine receptors in the brain and body are more complex and dynamic than previously thought, existing in diverse inactive states that only allow the...
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Rats with a disrupted transcription factor 7-like 2 (Tcf7l2) gene in the medial habenula showed markedly greater nicotine intake than control rats. Reduced Tcf7l2 expression in the medial habenula reduced...
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Healthcare already has effective tools including medications for opioid and alcohol use disorder, but they are not being utilized widely enough. One important reason is the stigma that surrounds people...
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Just published research by scientists at NIDA’s Intramural Research Program reveals that the drug cocaine causes neurons to synthesize endocannabinoids that are then enclosed within membrane-bound packages, known as extracellular...
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Mice genetically engineered to lack mu opioid receptors in the medial habenula were less sensitive to the unpleasant effects of the opioid antagonist naloxone and showed fewer naloxone-induced withdrawal symptoms.
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As people across the U.S. and the rest of the world contend with coronavirus disease 2019 (COVID-19), the research community should be alert to the possibility that it could hit...
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About 1 in 20 patients treated for a nonfatal opioid overdose in an emergency department died within 1 year of their visit, many within 2 days. Two-thirds of these deaths...