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About Us
What Is the IRP?
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Biomedical Engineering & Biophysics
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The Body
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Investing in Cutting-Edge Animal Models
Creating Cell-Based Therapies
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Charting the Pathways of Inflammation
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Uncovering New Opportunities for Natural Products
Stimulating Neuroscience Research
Pursuing Precision Medicine
Unlocking the Potential of RNA Biology and Therapeutics
Producing Novel Vaccines
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Virtual Realities, Real Discoveries
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The Body
Blood and Lymphatic System
Changes in blood proteins indicate aging trajectories
2018
Rethinking how the brain removes waste
2017
Creating a blood test to predict recurrence of a common lymphoma
2015
Donor telomere length affects survival after hematopoietic cell transplantation for severe aplastic anemia
2015
Brain and Nervous System
Coordinated ‘ripples’ of brain activity signal successful memory retrieval
2019
Neuron-specific genome modification in the adult rat brain using CRISPR-Cas9
2019
A brainstem-spinal circuit controlling movement in response to pain
2018
A sneak peek into the social brain: miniScope imaging reveals neural coding of social behavior
2018
How paying attention helps improve our memory
2018
Nicotinamide riboside (NAD+) prevents DNA damage and shows cognitive benefits in preclinical model of Alzheimer’s disease
2018
Organization of bigger brains shows how thinking drives brain development
2018
Pair of proteins repairs cellular highway system
2018
Point-of-care diagnostics: a blood biomarker to diagnose mild traumatic brain injuries
2018
Somatostatin: a key factor in the transmission of itch and pain
2018
Tracing pathways in the brain to understand how light affects mood and learning
2018
Understanding key components of the brain’s stress circuitry
2018
Antibodies to infections can cause neurological disorders
2017
Biomarker in blood may predict recovery time after sports concussion
2017
Chemogenetics revealed: converted clozapine activates lab-designed neuronal receptors
2017
How cells combat prions and amyloids
2017
Immune cells mediate the repair of blood vessels following traumatic brain injury
2017
Mitochondria power neuronal axon growth and regeneration
2017
Noninvasive imaging technique tracks brain activity with pinpoint precision
2017
Skill learning encoded via brain’s parallel processing in cortex and striatum
2017
A method of unraveling neural encoding mechanisms
2016
Amygdala is as important as the ventral striatum for reinforcement learning
2016
Better techniques for untangling correlations in big fMRI data
2016
Discovery of a new protein triaging pathway for neurotoxic proteins
2016
Finding molecular signatures of Alzheimer’s disease in blood extracellular vesicles
2015
Watching deep-brain movement circuits in action
2015
Alzheimer’s disease: challenging the amyloid dogma
2013
Detecting brain changes years before Alzheimer’s disease onset
2013
Finding the key to dendritic spine development
2013
Itching for an answer
2013
Mapping the adult mouse brain using embryonic gene expression
2013
Mind-body practices and yoga may protect against neurodegenerative effects of chronic pain
2013
New views of emotional regulation and decision making
2013
Fission and fusion to help keep our cells healthy
2012
How voltage ion channels interact with their surroundings
2009
Yeast proteins teach us about Alzheimer’s disease
2008
Moving toward understanding polyglutamine toxicity
2001
Understanding the breathing rhythm: respiratory pacemaker neurons located in the brain
1999
The first understanding of how brain cells communicate
1970
Digestive System
Mapping Irritable Bowel Syndrome
2014
Creating a new method to measure abdominal pain
2010
Ear, Nose, and Throat
Linking genetic mutations to two rare facial conditions
2017
Guarding against hearing loss from anti-cancer drugs
2014
Understanding deafness: the role of auditory nerve mapping
2012
Endocrine System (Hormones)
Gestational diabetes provides a warning sign for increased risk of chronic diseases later in life
2018
Hormones boost gene activity through super enhancers
2016
Taking a closer look at our on/off relationship with insulin
2012
Tracking the devastating effects of diethylstilbestrol (DES), a trans-placental carcinogen
2011
Eyes and Vision
Unraveling a complex world of neuronal connections
2011
Anatomy of Perception: Identifying Two Visual Streams in the Brain
1982
Heart and Circulation
Mechanism of age-associated failure of the heart’s pacemaker
2018
New therapy provides faster treatment for heart attacks
2018
Salt intake and sodium pump inhibitor linked to aortic stiffening and cardiovascular diseases
2018
Linking psoriasis inflammation and treatment with risk for cardiovascular disease
2017
Immune System
A new treatment for a rare blood disorder
2019
How periodic calorie restriction bolsters the immune system
2019
Organisms that live on your skin help heal your wounds
2019
Insights into influenza through human challenge
2016
Dissecting the immune response
2015
Learning that cells can use their nuclei like pistons to move
2014
Programmed cell death drives generation of immune system’s regulatory T cells
2014
Discovering monogenic forms of common variable immunogenicity
2012
Reclassification of diseases improves understanding and outcomes
2011
Discovery of interleukin-2 (IL-2)
1976
Kidney and Urinary System
Understanding health disparities in kidney disease
2010
Mental Health and Behavior
Ketamine for the treatment of depression and other anxiety-related disorders
2016
Identifying a key neurological regulator of social memory and aggression
2014
Understanding sensory symptoms in autism: seeing the trees, but not the forest
2014
Exploring racial differences in antidepressant response
2013
Identifying an Alzheimer’s disease risk gene
2013
Spur of the moment purchase? Blame your orbitofrontal cortex
2012
Stimulating new ideas on caffeine action in the brain
2011
The need for speed: A new approach to treating depressive disorders
2010
Could you become addicted to something? Your genes reveal all
2008
First successful treatment of childhood schizophrenia
1994
First successful treatment of childhood OCD
1985
A sense of calm in bipolar disorder: The clinical trials of lithium
1970
Mouth and Teeth
Immune cells linked to new model of gum disease
2018
Reproduction and Sexual Health
Battle of the sexes: When the female embryo takes control
2017
Delaying pregnancy: Can we test how fast the biological clock is ticking?
2017
How membrane fusion and fission occur in live cells
2017
Quantitative control mechanisms ensure the fidelity of cell division
2017
Skin, Hair, and Nails
Learning about human skin’s microbiota
2014
Only skin deep? New insights on retinoic acid in skin development
2012
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