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Accomplishments by Date
2020
A Nobel win for the discovery of the hepatitis C virus
A novel method for producing astatine-based cancer therapeutics
Discovery of a new form of immunotherapy for the treatment of cancer
Genetic and immunologic underpinnings of some cases of severe COVID-19
2019
A new treatment for a rare blood disorder
Coordinated ‘ripples’ of brain activity signal successful memory retrieval
Drugs for DIPG: a guide for new therapies in a rare, lethal pediatric brain cancer
For older adults, every step counts
How periodic calorie restriction bolsters the immune system
Neuron-specific genome modification in the adult rat brain using CRISPR-Cas9
Organisms that live on your skin help heal your wounds
Potential new treatment paradigm for WHIM patients with refractory disease
Revealing the structure of a sugar-transferring enzyme associated with colorectal cancer
Visualizing the structure and coordination of the DNA replication machinery
2018
A brainstem-spinal circuit controlling movement in response to pain
A novel mRNA modification may impact the human genetic code
A novel treatment for opioid use disorders
A sneak peek into the social brain: miniScope imaging reveals neural coding of social behavior
Changes in blood proteins indicate aging trajectories
Control of secretory granule maturation by the pgant9 gene
Controlling liver cancer via the gut microbiome
Gestational diabetes provides a warning sign for increased risk of chronic diseases later in life
How enzymes in the cell membrane add grease to other cellular proteins
How paying attention helps improve our memory
Immune cells linked to new model of gum disease
Iron exporter mutations provide malaria protection but predispose African Americans to iron overload disease
Is cigarette choice genetic? Examining connections between race and a preference for menthol
Mechanism of age-associated failure of the heart’s pacemaker
Metarrestin: a new approach to targeting the leading cause of cancer mortality
Mitochondria in age-related disease: The importance of heteroplasmy
New therapy provides faster treatment for heart attacks
Nicotinamide riboside (NAD+) prevents DNA damage and shows cognitive benefits in preclinical model of Alzheimer’s disease
Organization of bigger brains shows how thinking drives brain development
Pair of proteins repairs cellular highway system
Point-of-care diagnostics: a blood biomarker to diagnose mild traumatic brain injuries
Promising new treatment for fatal neurological disease Niemann-Pick type C1
Rewarding social interaction prevents drug addiction in rats
Salt intake and sodium pump inhibitor linked to aortic stiffening and cardiovascular diseases
Somatostatin: a key factor in the transmission of itch and pain
Tracing pathways in the brain to understand how light affects mood and learning
Trust your gut: probiotics could directly block staphylococcus infection
Understanding key components of the brain’s stress circuitry
2017
A good sugar for treating diabetes
Alpha-4 beta-7 integrin in HIV pathogenesis
Antibodies to infections can cause neurological disorders
Aortic valve replacement in patients with inadequate arterial access
Battle of the sexes: When the female embryo takes control
Biomarker in blood may predict recovery time after sports concussion
Chemogenetics revealed: converted clozapine activates lab-designed neuronal receptors
Delaying pregnancy: Can we test how fast the biological clock is ticking?
Discovering how cells repair lethal DNA-protein crosslinks
Discovering X-linked acrogigantism: a new infant-onset overgrowth syndrome
Doubling the power of light-sheet microscopy
Effects of tobacco discount coupons and policy intervention on tobacco use disparities
Fostering the first FDA-approved drug for Merkel cell carcinoma
FOUND: Essential genes for cancer immunotherapy
How cells combat prions and amyloids
How membrane fusion and fission occur in live cells
How tumors invade and destroy tissues
Identifying novel monoclonal antibodies against Ebola virus
Immune cells mediate the repair of blood vessels following traumatic brain injury
Linking genetic mutations to two rare facial conditions
Linking psoriasis inflammation and treatment with risk for cardiovascular disease
Mapping platinum in the inner ear after chemotherapy
Mitochondria power neuronal axon growth and regeneration
New biomarkers associated with lingering cancer treatment fatigue symptoms
New forms of CRISPR with applications in biotechnology
New treatment for leukocyte adhesion deficiency type 1 (LAD1)
Noninvasive imaging technique tracks brain activity with pinpoint precision
Pain-free skin patch responds to blood sugar levels to manage type 2 diabetes
Potential compounds for prevention and treatment of prescription opioid abuse
Quantitative control mechanisms ensure the fidelity of cell division
Rethinking how the brain removes waste
Role of the ‘hunger hormone’ ghrelin in alcohol dependence
Skill learning encoded via brain’s parallel processing in cortex and striatum
Three-in-one antibody protects monkeys from HIV-like virus
2016
A method of unraveling neural encoding mechanisms
A novel treatment for cocaine use disorders
Amygdala is as important as the ventral striatum for reinforcement learning
Better techniques for untangling correlations in big fMRI data
Discovery of a new protein triaging pathway for neurotoxic proteins
Dual antibody treatment suppresses HIV-like virus
Engineering immunity to tumor elements
Enhanced risk-based lung cancer screening may prevent more deaths
Extending the genetic code: identifying new DNA bases
Folic acid levels impact the newborn epigenome and childhood asthma risk
Gene therapy to restore the architecture of the inner ear
High prevalence of electronic cigarette use among rural youth with asthma
Hormones boost gene activity through super enhancers
Improving detection and prevention of undiagnosed diabetes in African-descent populations
Increased physical activity is associated with lower risk of 13 types of cancer
Insights into influenza through human challenge
Ketamine for the treatment of depression and other anxiety-related disorders
Low-intensity smokers are at increased risk of earlier death
Repurposed drugs to the rescue: Treating Zika
Stimulating interferon genes to interfere with cancer
The many faces of the autophagy machinery: LAP as a critical regulator of inflammation
Treating fatigue: A novel and promising path forward
2015
Creating a blood test to predict recurrence of a common lymphoma
Designing a new method for live albumin labeling and lymphatic imaging
Dissecting the immune response
Donor telomere length affects survival after hematopoietic cell transplantation for severe aplastic anemia
Exploring the role of dopamine in cocaine abuse
Finding molecular signatures of Alzheimer’s disease in blood extracellular vesicles
Gaucher and Parkinson’s: Identifying one target for two diseases
Harnessing the immune system to fight epithelial cancers
Hepatitis C: Repurposing existing drugs and discovering new antivirals
Interleukin-22 therapy: Providing new hope for alcoholic hepatitis
Repurposing existing drugs and discovering new antivirals for hepatitis C
Sharper Images of Molecules Using Cryo-Electron Microscopy
Traumatic brain injury: Linking a key protein to long-term complications
Treating cocaine addiction with transcranial magnetic stimulation
Watching deep-brain movement circuits in action
2014
Approaching a treatment for marijuana addiction
Creating an artificial RNA receptor to deliver siRNA to Tumors
Discovering how amphetamine works in the brain
Extreme obesity may shorten life expectancy by up to 14 years
Finding new pathways in accelerated aging disorders
Guarding against hearing loss from anti-cancer drugs
HPV test better predicts cervical cancer risk than Pap test
Identifying a key neurological regulator of social memory and aggression
Identifying genetic risk for type 2 diabetes and obesity
Identifying humans’ oldest animal relatives provides insights into the genetics of evolution
Learning about human skin’s microbiota
Learning that cells can use their nuclei like pistons to move
Linking genetics to recurrent strokes in children with DADA2
Mapping Irritable Bowel Syndrome
NLM Scrubber: Paving the road to “Big Data” by securing patient privacy
Programmed cell death drives generation of immune system’s regulatory T cells
Repurposing drugs to fight Ebola
Revealing drug-resistant malaria’s genetic and molecular fingerprint
Safer and faster prion disease detection
Simple new tool makes treatment for neglected tropical diseases safer
Studying childhood stroke to better understand inflammatory diseases
Testing a potential vaccine for the Chikungunya virus
They might be giants: Understanding a childhood genetic defect
Time between morning wake-up and smoking a cigarette associated with rate of lung cancer risk
Understanding sensory symptoms in autism: seeing the trees, but not the forest
2013
Alzheimer’s disease: challenging the amyloid dogma
Can fewer doses of HPV vaccine provide immunity?
Candidate vaccine against RSV, a common childhood infection
Detecting brain changes years before Alzheimer’s disease onset
Developing a vaccine for all four dengue viruses
Digging deeper into the basic principles of gene regulation
Discovering a new hepatitis C gene—and its implications for precision medicine
Exploring racial differences in antidepressant response
Finding the key to dendritic spine development
Identifying an Alzheimer’s disease risk gene
Investigational malaria vaccine found to be safe and protective
Itching for an answer
Linking a genetic variant to alcoholism
Mapping the adult mouse brain using embryonic gene expression
Mind-body practices and yoga may protect against neurodegenerative effects of chronic pain
New views of emotional regulation and decision making
Power in numbers: identifying new genes associated with ankylosing spondylitis
Protecting salivary glands from irradiation damage
Seeing the shape of hepatitis B’s action
Stimulating brain cells prevents compulsive cocaine seeking
Tackling the mysteries of osteosarcoma in children by uncovering gene variants associated with risk
The calculus of calories: mathematical models to quantify obesity and its treatment
Visualizing chromosomal translocations in living cells
Visualizing DNA repair in action
2012
A new approach to treating organ damage in inflammatory diseases
A non-addictive form of cocaine? A potential therapy awaits
Can we outwit the influenza virus with a universal vaccine?
Chronic drinking may alter the brain and increase PTSD risk
Disaster response tools that find missing people and save lives
Discovering monogenic forms of common variable immunogenicity
DNA and damage control: A complex web of players
Exposing “silent” heart attacks through novel imaging techniques
Fission and fusion to help keep our cells healthy
Identifying a promising HIV vaccine target
Linking heavy exposure to diesel exhaust to lung cancer deaths in miners
Medical radiation and cancer: minimizing the risk from CT scans
Only skin deep? New insights on retinoic acid in skin development
Open your eyes to the power of image-based online searching
Peripheral CB1 cannabinoid receptors as therapeutic targets in obesity and diabetes
Spur of the moment purchase? Blame your orbitofrontal cortex
Taking a closer look at our on/off relationship with insulin
Understanding deafness: the role of auditory nerve mapping
Understanding genetic recombination in a multi-cellular organism
Using genetics to understand stuttering
Visualizing a viral infection as it happens
Visualizing coronary artery disease
2011
Advancing rapid detection of prion diseases
Pioneering closed-chest hole-in-the-heart repair
Reclassification of diseases improves understanding and outcomes
Stimulating new ideas on caffeine action in the brain
Taking the random out of biopsy sampling
Team science unravels the link between ALS and FTD
Tracking the devastating effects of diethylstilbestrol (DES), a trans-placental carcinogen
Understanding bacterial immune systems
Unraveling a complex world of neuronal connections
2010
Creating a new method to measure abdominal pain
Deciphering how chromosomal mix-ups lead to tumors
Finding independent roles for different cellular ESCRTs
Foundation for CAR T-cell therapy Yescarta
Illuminating a path toward HIV vaccine development
Stopping Dengue in its tracks
The need for speed: A new approach to treating depressive disorders
The Teaching Tool: A digital cervix for colposcopists
Understanding health disparities in kidney disease
2009
How voltage ion channels interact with their surroundings
2008
Could you become addicted to something? Your genes reveal all
Diseases with no diagnosis: Providing relief for the rare and unknown
Yeast proteins teach us about Alzheimer’s disease
2006
Inventing sharper and faster optical microscopes for live cell imaging
2004
Developing a better way to monitor the size of slow growing, complex tumors
2002
Using adoptive cell transfer to treat advanced cancer
2001
Identifying and understanding rare immune system diseases
Moving toward understanding polyglutamine toxicity
The HPV vaccine: Two decades of research pays off
There’s no “magic bullet” for cancer. Or is there?
2000
Developing efficient modification of genomic DNA through recombineering
Discovering new tuberculosis drugs
Finding one disease is actually many: Diffuse large B-cell lymphomas
From hormone to pharmaceutical: lipodystrophy
1999
Understanding the breathing rhythm: respiratory pacemaker neurons located in the brain
1998
Understanding and sensing DNA damage
1997
Breaking down complex autoinflammatory diseases, and building up new hope
1996
Dissecting good from bad with laser-capture
1995
In the fight against viral hepatitis A, vaccines save lives
Lifting the lid on kidney cancer: Exposing the underlying genetics
1994
First successful treatment of childhood schizophrenia
IL-15: Taking an immunotherapy from bench to bedside
1991
Advancing early, rapid diagnosis of river blindness
Therapy for inherited enzyme deficiencies
1989
Discovering a growth factor and its incredible healing powers
Protecting at-risk children from a severe respiratory disease
1985
First detection and screening of the HIV virus
First electronic medical record to support clinical research
First successful treatment of childhood OCD
Hitting HIV hard with HAART therapy
1984
Demonstration that HTLV-III is the causative agent of AIDS
1982
Anatomy of Perception: Identifying Two Visual Streams in the Brain
1981
Discovery of the disease agent causing Lyme disease
1980
Discovery of the first human retroviruses
1976
Discovery of interleukin-2 (IL-2)
1974
Developing the first rotavirus vaccine
1970
A sense of calm in bipolar disorder: The clinical trials of lithium
The first understanding of how brain cells communicate
1957
Fluoridation: A public health milestone to make us all smile
1951
Understanding and Treating Fungal Infections
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