Program Snapshot
The High-Risk, High-Reward Research program has four unique funding opportunities for exceptionally creative scientists who propose highly innovative approaches to major challenges in biomedical research:
In the News
Developing an Auto-Focusing Contact Lens Modeled after Fish
Hongrui Jiang, a 2011 New Innovator, designed extremely small, super light-sensitive sensors inspired by the retina of elephant nose fish. The work is a step towards creating a contact lens that autofocuses within milliseconds that can be used to treat presbyopia. Jiang's work is featured in an NIH press release and on Discovery News. Read more
PBS's NOVA Features Christine Denny in "Memory Hackers"
Christine Denny, a 2013 Early Independence awardee, was featured in PBS's NOVA "Memory Hackers," which aired February 10, 2016 on PBS. The special examines the science of memory editing.
Crossing the Blood-Brain Barrier to Deliver Genes
Viviana Gradinaru, a 2013 New Innovator, modified a virus so it is capable of crossing the blood-brain barrier to deliver genes to nervous system cells. The virus could help researchers map the brain and deliver therapeutics. Read more.
Hibernation and Human Health
William Israelsen, a 2015 Early Independence awardee, is featured in the NIH Director's Blog discussing his research on how hibernating animals alter their metabolism over the course of the year, and what those findings may reveal about human obesity, cancer, and other health conditions.
Registration is now open!
Program Booklet • Abstracts • Photos • Videocasts for Day 1, Day 2, and Day 3
Application Information
| APPLICATION STATUS | ||||
|---|---|---|---|---|
| Pioneer Award | New Innovator Award |
Transformative Research Award |
Early Independence |
|
| FY 2017 |
RFA-RM-16-005 |
RFA-RM-16-004 |
RFA-RM-16-007 |
RFA-RM-16-006 |
Announcements
Congratulations to the 2017 PECASE recipients for their High-Risk, High-Reward Research projects! High-Risk High-Reward Research awardees who received PECASE awards for research projects supported by other agencies include Aaron Esser-Kahn (New Innovator), Ahmad Khalil (New Innovator), Elizabeth Nolan (New Innovator) and Harris Wang (Early Independence awardee).
Pioneer • New Innovator • Transformative Research • Early Independence
