The Adductomics Research Program promotes adducts/adductomics research-based strategies to identify a wide variety of molecular signatures for assessing risks, both exogenous and endogenous, as well as the combined effects to aid in optimization of cancer screening and prevention strategies. A priority will also be placed upon combining adduct signatures with other types of molecular signatures, such as DNA repair defects, capacity, and structure, gene mutations and genomic alterations, non-coding RNAs (ncRNAs), and imaging for cancer risk identification, early detection, and prevention. Furthermore, the program supports projects that evaluate the potential roles of adducts in cancer etiology and conducts studies of adducts for gene-environment interaction research (GxE).

Active PARs

PAR-19-251: Basic and Translational Research on Adducts in Cancer Risk Identification and Prevention (R01 Clinical Trial Optional)

PAR-19-252: Basic and Translational Research on Adducts in Cancer Risk Identification and Prevention (R21 Clinical Trial Optional)

Administration

This is a trans NIH-Program co-supported by National Cancer Institute (NCI) and National Institute of Environmental Health Sciences (NIEHS).  The Division of Cancer Prevention is the primary Division.