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OCCPR: A Leader in Cancer Proteomics and Proteogenomics

The mission of the NCI’s Office of Cancer Clinical Proteomics Research (OCCPR) is to improve prevention, early detection, diagnosis, and treatment of cancer by enhancing the understanding of the molecular mechanisms of cancer, advance proteome and proteogenome science and technology development through community resources (data and reagent), and accelerate the translation of molecular findings into the clinic. This is achieved through OCCPR-supported programs such as the Clinical Proteomic Tumor Analysis Consortium (CPTAC), partnerships with Federal agencies, and collaborations with international organizations/institutions.

The International Cancer Proteogenome Consortium

International Cancer Proteogenome Consortium

Learn about ICPC and how the consortium is breaking down silos to advance proteogenomic cancer research worldwide.

News and Announcements

May 15, 2020
Joint Proteomic and Genomic Data Release for Head and Neck Squamous Cell Carcinoma

108 cases of the NCI’s Clinical Proteomic Tumor Analysis Program (CPTAC) Head and Neck Squamous Cell Carcinoma Discovery Study have been proteomically and genomically profiled!  Each case includes HPV-negative, treatment naive and normal adjacent tissue, and includes proteomic ad phosphoproteomic data on the Proteomic Data Commons (PDC), as well as RNA-Seq, miRNA-Seq, WGS, WXS genomic data on the

May 5, 2020
50 New AML Pathology Slides on TCIA-CPTAC Pathology Portal

50 new pathology slides from 33 new Acute Myeloid Leukemia (AML) subjects are now available on the TCIA-CPTAC Pathology Portal. The April 2020 image release brings the total number of AML pathology slides to 120 from 88 subjects, with most of them also having both tumor blood and marrow imaging. 
April 29, 2020
OCCPR Webinar: LinkedOmics

Scientists from the Clinical Proteomics Tumor Analysis Consortium (CPTAC) program developed a powerful tool to explore associations between multiple types of omics datasets.  The LinkedOmics software collects genomic, transcriptomic and proteomic datasets from

April 21, 2020
CPTAC Researchers Identify New Features of Ovarian High-Grade Serous Cancer Associated with Patient Survival Rates and Alternative Drug Therapies

In a study published on April 21, in Cell Reports Medicine, researchers with the National Cancer Institutes’ (NCI) Clinical Proteomics Tumor Analysis Consortium (CPTAC) take a comprehensive look at the root causes of ovarian high-grade serous carcinoma (HGSC).  Through integrated proteomic and genomic an
April 14, 2020
150 New Assays on the NCI Assay Portal!

One of the missions of theClinical Proteomic Tumor Analysis Consortium (CPTAC) is to provide proteomic resources to the greater scientific community.  So, we have great news to announce!  CPTAC has added 150 "fit-for-purpose," multiplexed, mass spectrometry-based proteomic targeted assays to its Assay Portal!
April 7, 2020
New Quarterly Release of CPTAC Radiology Imaging Data Available

It’s that time again!  CPTAC radiology images have been released on the TCIA CPTAC Pathology Portal!  Between conference calls and literature searches, take a look at the 38 new radiology and 8 new pathology images added to Portal – all for free!
March 27, 2020
OCCPR Webinar: Network Exploration Tool for Cancer Research

Finding novel interactions from comprehensive genomics and proteomics (mass spectrometry generated) is made significantly easier with the help of a visual, interactive guide.
March 23, 2020
The Proteomic Data Commons Is Now Live!

NCI announces the launch of the NCI Proteomic Data Commons (PDC)!
March 17, 2020
New CPTAC Imaging Data Available

New histopathology slides available from CPTAC lung squamous cell carcinoma, lung adenocarcinoma and glioblastoma multiforme studies. 149 images from 28 new cases added in the month of February 2020 are publicly available on the TCIA CPTAC Pathology Portal!
March 10, 2020
Making Space for Ubiquitin Proteomics

Protein ubiquitylation is best known for its role in degradation, leading molecules to the cell’s recycle bin, but it also has roles in cellular processing and protein interactions.  Unfortunately, research using proteomic techniques have been limited due to experimental and technical complications.    

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